NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Di...(without initial complaints. This is the ...)

Date:7/25/2008

without initial complaints. This is the first prediction study to link subjective cognitive impairment to both mild cognitive impairment and dementia and underlines the importance in studying early, non-specific symptoms that arise before mild cognitive impairment is apparent, the researchers report. Such efforts are critical to preventing the disease. To develop preventive interventions it may be necessary to accurately identify the disease in its earliest manifestations, when symptoms are first emerging, say the NYU researchers. These subjective symptoms appear to occur as early as twenty or more years before the overt dementia of Alzheimer's appears.
Presentation # PS-043

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A Decreasing Ability to Learn Among Aging Healthy Carriers of APOE 4
Nunzio Pomara, M.D., Professor in the Department of Psychiatry, NYU Langone Medical Center; Director of the Geriatric Psychiatry Program, Nathan S. Kline Institute
EMBARGOED FOR RELEASE WEDNESDAY, July 30, 2008, at 1 PM CT

A new study by NYU researchers at the Nathan Kline Institute suggests that a major genetic risk factor for Alzheimer's disease, apoE 4, may exert its adverse effects long before clinical symptoms of the disease emerge. During this critical period they believe there may be a gradually decreasing ability to learn new material, and subsequently form new memories. The scientists evaluated 184 healthy adults, ages 38 to 80 (64 people carried the apoE4 allele), using standardized measures of verbal learning and memory, such as learning a list of words. At younger ages, surprisingly, those with the apoE 4 genetic risk factor significantly outperformed those without it. By ages 60 to 64 and older, however, performance in the apoE 4 group dropped below the non-apoE 4 group.
Presentation # HT-3577

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Genetic Mutation Linked to a More Abundant Form of Alzheimer's Protein
Allal Boutajangout, PhD, Research Assistant Professor, Depa
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Contact: Bob Brody bobbrody@hotmail.com 212-404-3555 NYU Langone Medical Center / New York University School of Medicine Source:Eurekalert

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