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NYU Langone Medical Center's tip sheet to the 2011 Alzheimer's Association International Conference
Date:7/15/2011

unclear. This study focused on defining the relationship between hyperglycemia (hGly) and the Aβ pathology in AD transgenic (Tg) animals. The researchers found that chronic hyperglycemia is strongly associated with exacerbation of Aβ pathology in AD Tg mice, and primarily aggravated cerebral amyloid angiopathy (CAA), which is allied with increased damage to blood vessel integrity. It also promoted formation of Aβ oligomers which enhances Aβ toxicity.


Conformation Directed Immunomodulation Effectively Targeting amyloid plaques, CAA and neurofibrillary tangle pathology in Model Mice
Fernando Goni, PhD, research associate professor in the Department of Neurology, NYU School of Medicine

EMBARGOED FOR RELEASE UNTIL WEDNESDAY JULY, 20, 2011 DURING DEVELOPING TOPICS

Alzheimer's disease is the most common of the conformational neurodegenerative disorders. Current treatments for AD are largely symptomatic and minimally effective. Issues with previous immunotherapeutical approaches include: the potential of toxicity from autoimmune encephalitis, tau related pathology not being addressed, and the need to effectively clear congophilic angiopathy (CAA). For the current study a novel immunomodulatory therapeutic approach was developed using polymerized British amyloidosis (pABri) related peptides with no homology to any human protein; and polymerized-non-fibrillized-Aβ1-42 peptide (pAβ42), to help overcome these limitations of vaccination. In the past it has been demonstrated that pABri can induce behavioral benefits in APP/PS1 Tg mice associated with reductions in Aβ oligomers. This approach was tested in mice with both plaques and tangle pathology (3xTg mice) and mice with extensive CAA (TgSwDI). The pABri inoculated animals made low titers of IgM and IgG recognizing the original antigen and oligomerized Aβ42. Animals inoculated with pAβ42 had high titers of anti-Aβ peptides
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Contact: Lorinda Klein
lorindaann.klein@nyumc.org
212-404-3533
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

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