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NYU Langone Medical Center's tip sheet to the 2011 Alzheimer's Association International Conference
Date:7/15/2011

haracterization of Mild Cognitive Impairment in Retired NFL Players
Stella Karantzoulis, PhD, assistant professor in the Department of Neurology, NYU Comprehensive Epilepsy Center, NYU Langone Medical Center

EMBARGOED FOR RELEASE UNTIL MONDAY, JULY 18, 2011, 7:30am CEST (1:30am ET/USA)

It has been suggested that retired American football players may be at increased risk for late-life cognitive disorders although this has not yet been definitively established. Isolated findings have been reported of chronic traumatic encephalopathy in athletes who have been exposed to repetitive head trauma. In this study, 41 retired NFL athletes were compared to two groups; a demographically-matched cognitive intact cohort and a clinical sample of patients with amnestic (forgetfulness) on a neurocognitive series of tests. Results indicated that the prevalence of mild cognitive impairment (MCI) within the sample of retired athletes appears to be higher than epidemiological studies would predict. The researchers conclude that MCI may be more common in retired NFL athletes than in the general population.


Immunization with a pseudo-phosphorylated tau epitope clears tau pathology in a mouse model.
Pavan Krishnamurthy, PhD, instructor in the Department of Physiology and Neuroscience, NYU School of Medicine

EMBARGOED FOR RELEASE ON JULY 18, 2011 AT 12:30PM CEST (6:30amET/USA)

Immunotherapy holds great promise for Alzheimer's disease (AD) and other conformational disorders. Recent studies have shown that immunization with an AD specific phospho-tau immunogen Tau379-408[P-Ser396,404] alleviates brain levels of aggregated tau and slows the progression of motor deficits or prevents cognitive impairments in two different tangle models. To assess potential epitope specificity and safety of this promising therapeutic effect, the researchers examined several tau epitopes. The results support the feasibility of tau immunotherapy
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Contact: Lorinda Klein
lorindaann.klein@nyumc.org
212-404-3533
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

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