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NYU Langone Medical Center researcher named Howard Hughes Investigator
Date:5/9/2013

s other scientific contributions, his team was the first to discover bits of RNA present in all life forms that function as molecular circuits to control gene expression. These so-called "riboswitches" are now promising new targets for synthetic molecular switches and antimicrobial therapies. His lab has also developed a suite of biochemical tools to examine how RNA polymerase transcribes RNA from DNA. RNA polymerase is key enzyme of gene regulation and Nudler's work has explained how it moves along DNA, responds to regulatory signals and factors, and terminates transcription. Finally, Dr. Nudler's lab has identified the key biochemical components that allow cells to cope with high temperature and other types of stress that jeopardize the integrity of proteins. A better understanding of these components could lead to therapies that help repair damaged proteins related to cancer and neurodegenerative diseases such as Alzheimer's and Amyotrophic lateral sclerosis (ALS).


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Contact: Lisa Greiner
lisa.greiner@nyumc.org
212-404-3532
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

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