Navigation Links
NYU Langone Medical Center researcher named Howard Hughes Investigator

NEW YORK, May 9, 2013 The Howard Hughes Medical Institute (HHMI) has announced the appointment of Evgeny Nudler, PhD, to the 2013 class of HHMI Investigators.The appointment ranks as one of the highest honors that can be bestowed on a biomedical research scientist. Dr. Nudler, the Julie Wilson Anderson Professor of Biochemistry in the Department of Biochemistry and Molecular Pharmacology at NYU Langone Medical Center, was selected among more than 1,200 applicants for his work on numerous biochemical frontiers, including the role of bacterial gases in antibiotic resistance and the interplay between RNA transcription and the cellular response to stress.

"The depth and breadth of Evgeny Nudler's research is absolutely remarkable," said Dafna Bar-Sagi, PhD, senior vice president and vice dean for science and chief scientific officer at NYU School of Medicine. "The five highly unique projects underway in his lab hold promise for a broad range of diseases, from cancer and heart disease to bacterial infections and Alzheimer's. His versatility and range are invaluable, and his selection as an HMMI Investigator is richly deserved."

Most recently, Dr. Nudler and his colleagues have discovered how the roundworm exploits bacteria within its gut to harness the life-extending benefits of nitric oxide, a gas implicated in a wide range of physiological functions from blood pressure to immune response in mammals. This finding could help unravel the mysteries of human longevity, as our cells may employ a similar biochemical mechanism.

Bacteria cells also exploit nitric oxide for their own purposes, Dr. Nudler has found. In a discovery that sheds light on antibacterial resistance, his team has revealed how the dangerous bacterial species Staphylococcus aureus and Bacillus anthracis manufacture nitric oxide and hydrogen sulfide to guard against oxidative stress and evade many different classes of antibiotics.

Among Dr. Nudler's other scientific contributions, his team was the first to discover bits of RNA present in all life forms that function as molecular circuits to control gene expression. These so-called "riboswitches" are now promising new targets for synthetic molecular switches and antimicrobial therapies. His lab has also developed a suite of biochemical tools to examine how RNA polymerase transcribes RNA from DNA. RNA polymerase is key enzyme of gene regulation and Nudler's work has explained how it moves along DNA, responds to regulatory signals and factors, and terminates transcription. Finally, Dr. Nudler's lab has identified the key biochemical components that allow cells to cope with high temperature and other types of stress that jeopardize the integrity of proteins. A better understanding of these components could lead to therapies that help repair damaged proteins related to cancer and neurodegenerative diseases such as Alzheimer's and Amyotrophic lateral sclerosis (ALS).


Contact: Lisa Greiner
NYU Langone Medical Center / New York University School of Medicine

Related biology news :

1. St. Jude scientist named Howard Hughes Medical Institute investigator
2. Using bacteria-eaters to prevent infections on medical implant materials
3. Shared Medical Resources, LLC files suit against Histologics, LLC, Womens Health Laboratories and Avero Diagnostics for Willful Patent Infringement
4. BUSM study shows positive impact of mind-body course on well-being of medical students
5. Quest for edible malarial vaccine leads to other potential medical uses for algae
6. New cutting-edge cell research will lead to safer medical experiments on humans
7. PeerJ launches PeerJ PrePrints -- a preprint server for the biological and medical sciences
8. Columbia University Medical Center/NY-Presbyterian experts at AAN
9. CWRU spinoff ConservoCare gets licensing options to develop medical device for bladder control
10. Paving the way for greater use of ancient medical knowledge
11. Sanford-Burnham Medical Research Institute and Mayo Clinic extend collaborative agreement
Post Your Comments:
(Date:11/17/2015)... SOUTH EASTON, Mass. , Nov. 17, 2015 /PRNewswire/ ... "Company"), a leader in the development and sale of ... to the worldwide life sciences industry, today announced it ... closing of its $5 million Private Placement (the "Offering"), ... Offering to $4,025,000.  One or more additional closings are ...
(Date:11/11/2015)... , Nov. 11, 2015   MedNet Solutions , an ... of clinical research, is pleased to announce that it will ... Trials (PCT) event, to be held November 17-19 in ... to view live demonstrations of iMedNet , ... how iMedNet has been able to deliver time ...
(Date:11/4/2015)... 2015 --> ... by Transparency Market Research "Home Security Solutions Market - Global ... - 2022", the global home security solutions market is expected to ... The market is estimated to expand at a CAGR ... 2022. Rising security needs among customers at homes, the ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... In ... paramount. Insertion points for in-line sensors can represent a weak spot where leaking ... 781/784 series of retractable sensor housings , which are designed to tolerate extreme ...
(Date:11/24/2015)... HemoShear Therapeutics, LLC, a privately held ... disorders, announced today the appointment of H. ... (BOD). Mr. Watkins is the former president and ... and also served as the chairman of the ... Chairman and CEO of HemoShear Therapeutics. "The combination ...
(Date:11/23/2015)... Women with a certain type of lung nodule ... risk of lung cancer than men with similar nodules, according ... annual meeting of the Radiological Society of North ... --> Lung nodules are small masses of tissue ... based on their appearance on CT. Solid nodules are dense, ...
(Date:11/23/2015)... The royalty-free a greement ... develop daclatasvir for 112 low- and m ... --> --> The Medicines Patent Pool (MPP) ... signing an agreement with Bristol-Myers Squibb for daclatasvir, a novel ... of the HCV virus.  The royalty-free licence will enable generic ...
Breaking Biology Technology: