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NYU Langone Medical Center awarded NIH grants totaling $1,560,000
Date:6/24/2009

er cannot be explained by any known environmental or host factors. He postulates that gastroesophageal reflux alters the esophageal microbiome and chronic exposure to an abnormal (altered) microbiome is carcinogenic. Initial research has shown that patients carrying particular types of microbiomes are more likely to have the early stages of esophageal adenocarcinoma than those who do not. His team will sample the oral cavity, esophagus, and stomach to study the relationship between the microbiome from these body sites and esophageal cancer.

Dr. Blaser and Dr. Pei lead two of only 15 teams selected in the United States to conduct pilot demonstration projects on behalf of the HMP.

"The Human Microbiome Project offers a fascinating opportunity to transform our understanding of the relationships between microbes and humans in health and disease," said Vivian S. Lee, MD, PhD, MBA, senior vice president, vice dean for science and chief scientific officer. "We congratulate Drs. Blaser and Pei as they continue to lead this frontier of medical research. The studies they are conducting transform the ways we understand human health and the critical interactions between microbiome and host across a wide range of conditions."

Each pilot demonstration project will be reviewed after one year to evaluate its progress toward milestones, as well as its ability to demonstrate a definable relationship between a body-site microbiome and disease.

In the first phases of the HMP, jumpstart funding was awarded to create a framework and data resources. Funding has also previously been awarded for the development of innovative technologies and computational tools, coordination of data analysis, and an examination of some of the ethical, legal and social implications of human microbiome research. The HMP plans to award more than $115 million in research grants during the project to sequence up to 600 microbial genomes and for selected demonstration proje
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Contact: Lisa Greiner
lisa.greiner@nyumc.org
212-404-3532
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

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