Navigation Links
NYU College of Dentistry awarded $1.9 million NIH grant for HIV research

Seeking to shed new light on HIV's ability to survive in the body and cause disease, the National Institute of Allergy and Infectious Diseases at the NIH has awarded a five-year, $1.9 million grant to an AIDS research team at the New York University College of Dentistry to continue its study of a new mode of HIV replication that involves cooperation between viruses.

The team leader, Dr. David N. Levy, an Assistant Professor of Basic Science and Craniofacial Biology, discovered the mechanism in an earlier study he conducted with the assistance of a one-year pilot grant from CFAR, The Center for AIDS Research at the NYU School of Medicine.

HIV normally inserts its DNA into the DNA of the cells it infects in a process called integration that is inefficient and prone to failure, and can result in an aborted virus replication cycle. As a result, up to 99 percent of HIV DNA is found in an unintegrated form. Although the abundance of unintegrated DNA has long been known, its biological significance has not been clear.

In a paper published in the July 2008 issue of the journal Retrovirology, Dr. Levy and his team demonstrated that the unintegrated viruses can, in fact, replicate when they are assisted or "complemented" by viruses that successfully integrate with the DNA of infected cells. Dr. Levy believes that this newfound cooperation among HIV viruses helps HIV persist in the body and evade immune responses.

"HIV rapidly mutates and evolves during infection, which prevents the immune system from successfully stopping virus replication," explains Dr. Levy, "and we have shown that these cooperative interactions speed up the evolution of the virus by increasing the amount of genetic exchange between viruses through a process called recombination.

"Previous work from my laboratory demonstrated that recombination between viruses occurs frequently, and our most recent study reveals that recombination is likely to be even more frequent than was previously thought.

"This new mode of virus replication has implications for many aspects of HIV biology and disease. Our expectation is that by better understanding this previously unknown mode of HIV replication, we can find new ways of slowing or stopping HIV replication and the disease it causes."


Contact: Christopher James
New York University

Related biology news :

1. High school students paper published in prestigious college math journal
2. Texas College Police Unit Deploys BIO-key(R) Mobile Data System
3. College students find comfort in their pets during hard times
4. Better beer: College team creating anticancer brew
5. American College of Medical Genetics receives $13.5M NIH contract
6. Ansary Symposium on Stem Cell Research at Weill Cornell Medical College
7. College cocktails lead to science career
8. American College of Medical Genetics makes genetic testing recommendations in new policy statement
9. Medical College researchers find dinosaur clues in fat
10. Where college students live can impact their weight, eating and exercise habits
11. Veterinary college researchers explore function of biofilm in bovine respiratory disease
Post Your Comments:
(Date:11/20/2015)... -- NXTD ) ("NXT-ID" or the "Company"), ... commerce market and creator of the Wocket® smart wallet, ... interviewed on The RedChip Money Report television ... Bloomberg Europe , Bloomberg Asia, Bloomberg Australia, and ... ) ("NXT-ID" or the "Company"), a biometric authentication company ...
(Date:11/19/2015)... -- Although some 350 companies are actively involved in molecular ... according to Kalorama Information. These include Roche Diagnostics, Hologic, Abbott ... of the 6.1 billion-dollar molecular testing market, according to ... Diagnostic s .    ... one company and only a handful of companies can ...
(Date:11/18/2015)... , November 18, 2015 ... published a new market report titled  Gesture Recognition Market ... Forecast, 2015 - 2021. According to the report, the global gesture ... is anticipated to reach US$29.1 bn by 2021, at ... North America dominated the global ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 2015 Studies reveal the differences ... and pave the way for more effective treatment for one ...   --> --> ... problems in cats, yet relatively little was understood about the ... have been conducted by researchers from the WALTHAM Centre for ...
(Date:11/25/2015)...  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced ... of Neurocrine Biosciences, will be presenting at the 27th ... York . .   ... minutes prior to the presentation to download or install ... be available on the website approximately one hour after ...
(Date:11/25/2015)... ... November 25, 2015 , ... A long-standing partnership between ... (OPBAP) has been formalized with the signing of a Memorandum of Understanding. , ... leaders Capt. Karl Minter and Capt. Albert Glenn Tuesday, November 24, 2015, at ...
(Date:11/25/2015)... , November 25, 2015 ... Report is a professional and in-depth study on ...      (Logo: ) , ... the industry including definitions, classifications, applications and industry ... for the international markets including development trends, competitive ...
Breaking Biology Technology: