Navigation Links
NYU College of Dentistry awarded $1.9 million NIH grant for HIV research
Date:3/5/2009

Seeking to shed new light on HIV's ability to survive in the body and cause disease, the National Institute of Allergy and Infectious Diseases at the NIH has awarded a five-year, $1.9 million grant to an AIDS research team at the New York University College of Dentistry to continue its study of a new mode of HIV replication that involves cooperation between viruses.

The team leader, Dr. David N. Levy, an Assistant Professor of Basic Science and Craniofacial Biology, discovered the mechanism in an earlier study he conducted with the assistance of a one-year pilot grant from CFAR, The Center for AIDS Research at the NYU School of Medicine.

HIV normally inserts its DNA into the DNA of the cells it infects in a process called integration that is inefficient and prone to failure, and can result in an aborted virus replication cycle. As a result, up to 99 percent of HIV DNA is found in an unintegrated form. Although the abundance of unintegrated DNA has long been known, its biological significance has not been clear.

In a paper published in the July 2008 issue of the journal Retrovirology, Dr. Levy and his team demonstrated that the unintegrated viruses can, in fact, replicate when they are assisted or "complemented" by viruses that successfully integrate with the DNA of infected cells. Dr. Levy believes that this newfound cooperation among HIV viruses helps HIV persist in the body and evade immune responses.

"HIV rapidly mutates and evolves during infection, which prevents the immune system from successfully stopping virus replication," explains Dr. Levy, "and we have shown that these cooperative interactions speed up the evolution of the virus by increasing the amount of genetic exchange between viruses through a process called recombination.

"Previous work from my laboratory demonstrated that recombination between viruses occurs frequently, and our most recent study reveals that recombination is likely to be
'/>"/>

Contact: Christopher James
christopher.james@nyu.edu
212-998-6876
New York University
Source:Eurekalert

Page: 1 2

Related biology news :

1. High school students paper published in prestigious college math journal
2. Texas College Police Unit Deploys BIO-key(R) Mobile Data System
3. College students find comfort in their pets during hard times
4. Better beer: College team creating anticancer brew
5. American College of Medical Genetics receives $13.5M NIH contract
6. Ansary Symposium on Stem Cell Research at Weill Cornell Medical College
7. College cocktails lead to science career
8. American College of Medical Genetics makes genetic testing recommendations in new policy statement
9. Medical College researchers find dinosaur clues in fat
10. Where college students live can impact their weight, eating and exercise habits
11. Veterinary college researchers explore function of biofilm in bovine respiratory disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2015)... Sweden , May 18, 2015 ... fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one ... from June until and including Q3 2015 and the sensors ... . Communicated order values for 2015 hereby amount to ... for Q1 2015 of 140 MSEK and a number of ...
(Date:5/11/2015)... 2015  Through a well-rounded UAS delegation representing private industry, ... strong showing at AUVSI,s Unmanned 2015 conference last week in ... Ohio,s UAS industry met with over 200 hundred ... along the UAS ecosystem. "Our message is ... for Aerospace Rich Knoll . "If you want to ...
(Date:5/7/2015)... Fingerprint Cards (FPC) introduces ... FPC,s smallest touch fingerprint sensors to date.  ... integration on the backside of the phone, and ... to integrate touch fingerprint sensors in the OEMs, ... for module manufacturers to customize the look and ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2
... discovered in Texas from a flying reptile that died 89 ... world of the prehistoric creature known as Pteranodon . ... Kansas, South Dakota and Wyoming in the Niobrara and Pierre ... first of its kind found in Texas, according to paleontologist ...
... of why spider silk fibers are so incredibly strong. ... 15th in Biophysical Journal, describes the architecture ... reveals new information about the molecular structure that underlies ... Spiders spin silk, which is remarkably strong and ...
... the association for professionals in biomedical and health informatics, ... Coordinator on Health Information Technology (DHHS/ ONCHIT), which has ... of electronic health records (EHRs) over the last year, ... (HITPC), on the continuation of support for achieving meaningful ...
Cached Biology News:Rare 89 million-year-old flying reptile fossil from Texas may be world's oldest Pteranodon 2Rare 89 million-year-old flying reptile fossil from Texas may be world's oldest Pteranodon 3Rare 89 million-year-old flying reptile fossil from Texas may be world's oldest Pteranodon 4Scientists unravel the mysterious mechanics of spider silk 2AMIA on meaningful use: Invest in people and technology 2
(Date:5/26/2015)... , Kalifornien und HILDEN, Deutschland, May 26, ... Clinical Insight ®   ... und die Erstellung dazugehöriger Berichte; Vorstellung auf ... QIAGEN N.V. (NASDAQ: QGEN ... die Markteinführung von QIAGEN Clinical Insight ® ...
(Date:5/26/2015)... Inc. (NYSE: ALR ) (the "Company") announced today that, ... Quarterly Report on Form 10-Q for the three months ended ... notice from the New York Stock Exchange (the "NYSE") that ... listing requirements under the timely filing criteria established in Section ... The reason for the delay relates to Company,s need to ...
(Date:5/26/2015)... May 26, 2015   PDI , a ... announced that Oakwood Healthcare in Dearborn, ... winning entry in Delivering the Difference ... display excellence in building collaborative relationships between infection ... healthcare facilities.  Oakwood Healthcare,s infection ...
(Date:5/26/2015)... LOS ANGELES , 26. mája 2015 /PRNewswire/ ... ďakuje v mene svojej rodiny prezidentom Barackovi Obamovi ... vyjadrenú v súvislosti so stratou Dr. Rongxiang ... - http://photos.prnewswire.com/prnh/20150522/218111 Dr. Xu ... svojej dobe a jeho odhodlanie v oblasti vedy ...
Breaking Biology Technology:QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 2QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 3QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 4QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 5QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 6PDI Announces Winner in Delivering the Difference Contest 2PDI Announces Winner in Delivering the Difference Contest 3Dr. Rongxiang Xu, O legende 2
... clearance for two new brain imaging applications, a local ... products to healthcare providers. , ,Approval from the ... Radiologic Health in June allowed Kyron Clinical ... line of brain mapping solutions based on functional and ...
... , Wis. - Platypus Technologies recently ... new line of products and court strategic partners - ... and nanotechnology company is prepared to expand its product ... used by researchers, and management is in discussions with ...
... Wis. - Local angel investor network Silicon ... Clearent, LLC , which is developing a next-generation credit ... , ,It's not unusual for Wisconsin-based investors to look ... of Silicon Pastures, said this investment opportunity arrived at ...
Cached Biology Technology:Kyron wins FDA approval for brain imaging technology 2Platypus ready to unveil new commercial lines 2Platypus ready to unveil new commercial lines 3Platypus ready to unveil new commercial lines 4
... a DNA-dependent RNA polymerase which is stringently ... efficiently synthesizes in vitro transcripts from almost ... a T7 promoter. Transcripts can be ... vitro translation, substrates in RNA processing systems, ...
... fragment is a proteolytic product ... DNA Polymerase I which retains ... exonuclease activity, but has lost ... retains the polymerization fidelity of ...
... Source: E. coli strain containing an overproducing clone ... catalyzes the formation of a phosphodiester bond between ... duplex DNA or RNA. It repairs single-stranded nicks ... will join both blunt-end and cohesive-end fragments of ...
SHEEP ANTI BOVINE BETA-LACTOGLOBULIN A...
Biology Products: