Navigation Links
NYU College of Dentistry awarded $1.9 million NIH grant for HIV research
Date:3/5/2009

Seeking to shed new light on HIV's ability to survive in the body and cause disease, the National Institute of Allergy and Infectious Diseases at the NIH has awarded a five-year, $1.9 million grant to an AIDS research team at the New York University College of Dentistry to continue its study of a new mode of HIV replication that involves cooperation between viruses.

The team leader, Dr. David N. Levy, an Assistant Professor of Basic Science and Craniofacial Biology, discovered the mechanism in an earlier study he conducted with the assistance of a one-year pilot grant from CFAR, The Center for AIDS Research at the NYU School of Medicine.

HIV normally inserts its DNA into the DNA of the cells it infects in a process called integration that is inefficient and prone to failure, and can result in an aborted virus replication cycle. As a result, up to 99 percent of HIV DNA is found in an unintegrated form. Although the abundance of unintegrated DNA has long been known, its biological significance has not been clear.

In a paper published in the July 2008 issue of the journal Retrovirology, Dr. Levy and his team demonstrated that the unintegrated viruses can, in fact, replicate when they are assisted or "complemented" by viruses that successfully integrate with the DNA of infected cells. Dr. Levy believes that this newfound cooperation among HIV viruses helps HIV persist in the body and evade immune responses.

"HIV rapidly mutates and evolves during infection, which prevents the immune system from successfully stopping virus replication," explains Dr. Levy, "and we have shown that these cooperative interactions speed up the evolution of the virus by increasing the amount of genetic exchange between viruses through a process called recombination.

"Previous work from my laboratory demonstrated that recombination between viruses occurs frequently, and our most recent study reveals that recombination is likely to be
'/>"/>

Contact: Christopher James
christopher.james@nyu.edu
212-998-6876
New York University
Source:Eurekalert

Page: 1 2

Related biology news :

1. High school students paper published in prestigious college math journal
2. Texas College Police Unit Deploys BIO-key(R) Mobile Data System
3. College students find comfort in their pets during hard times
4. Better beer: College team creating anticancer brew
5. American College of Medical Genetics receives $13.5M NIH contract
6. Ansary Symposium on Stem Cell Research at Weill Cornell Medical College
7. College cocktails lead to science career
8. American College of Medical Genetics makes genetic testing recommendations in new policy statement
9. Medical College researchers find dinosaur clues in fat
10. Where college students live can impact their weight, eating and exercise habits
11. Veterinary college researchers explore function of biofilm in bovine respiratory disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Aires yesterday, Argentina joins the European Molecular Biology ... move strengthens the ties between the European and ... scientists access to EMBL,s world-class facilities and programs, ... its inception, fostering excellent life science research and ... of EMBL,s mission," says EMBL Director General Iain ...
(Date:4/23/2014)... first cause of dementia and affects some 400,000 people ... been found. One of the reasons for this is ... cause alterations in nerve transmissions and the loss of ... from the Institute of Neuroscience at the Universitat Autnoma ... memory consolidation and were able to develop a gene ...
(Date:4/23/2014)... is leading a 2 million Food Standards Agency (FSA) ... premises and industry workers. , Norovirus outbreaks can ... a batch of frozen strawberries infected 11,000 people in ... understanding of which strains cause infection and which foods ... , Researchers will produce data that will help ...
Breaking Biology News(10 mins):Loss of memory in Alzheimer's mice models reversed through gene therapy 2
... Popeye cartoons, tasting parties and junior cooking classes can help ... published in the journal Nutrition & Dietetics . ... and amount of vegetables children ate improved after they took ... promote healthy food. Twenty six kindergarten children aged four ...
... continually emerging on the impacts of invasive species, ... Ecological scientists will discuss widespread environmental changesfrom the ... wild to the implications of mercury found in ... mode toward environmental disasters in the U.S.at the ...
... 2100 only 18% to 45% of the plants and ... may remain as we know them today, according to ... Carnegie Institution,s Department of Global Ecology. The research combined ... It is the first study to consider these combined ...
Cached Biology News:New research: Children's vegetable intake linked to Popeye cartoons 2Scientists find new evidence of genetically modified plants in the wild 2Scientists find new evidence of genetically modified plants in the wild 3Scientists find new evidence of genetically modified plants in the wild 4Global tropical forests threatened by 2100 2
(Date:1/15/2014)... Automotive, a group of car dealerships headquartered in ... Center and offering free oil change coupons for participation in ... 18 at the Bill Jacobs Cadillac and Chevrolet location from ... )  The Bill Jacobs Auto annual blood ...
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 ... for cancer, today announced the appointment of Thomas C Reynolds ... over 20 years, development experience gained in the biotechnology industry, ... "I am delighted to welcome Tom at this transformative ...
(Date:1/15/2014)... Two champions of science, technology, engineering, and ... annual competition for middle and high school students designed ... study. The competition presents students with real-world problems experienced ... Mathematics, and Sciences is a program administered by ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... Adeona Pharmaceuticals, Inc. (NYSE Amex: AEN ), ... diseases, announced today that James S. Kuo, M.D., M.B.A., the ... update on its Alzheimer,s program at the NYC Medtech Forum. ... invitation-only event on Tuesday evening, October 11, 2011, at the ...
... BioCrossroads today announced the receipt of a two-year ... will fund a range of charitable, educational and scientific ... Indiana,s signature strengths in the life sciences. ... 2012, we recognize that Lilly Endowment,s significant investment in ...
... Oct. 5, 2011 DATATRAK International, Inc. (OTCQX: DATA), ... solutions for the clinical trials industry, today announced the ... biologics and vaccines company.  Recognizing the value of enterprise ... unified software suite to conduct a series of trials. ...
Cached Biology Technology:Adeona CEO to Present at the NYC Medtech Forum 2Two-year $2.8 million Grant from Lilly Endowment Fuels BioCrossroads' Charitable, Educational and Scientific Mission 2Two-year $2.8 million Grant from Lilly Endowment Fuels BioCrossroads' Charitable, Educational and Scientific Mission 3DATATRAK Signs Multi-Year Agreement with Specialty Biotech 2
The Trans-Blot Plus gel and cassette assembly tray is used to hold the Trans-Blot Plus gel holder cassette, buffer, and other materials for the gel and membrane sandwich during their assembly....
... FXP is the latest entry in the Biomek ... accuracy and increased robustness, it can meet the ... be configured with either one or two pipetting ... FXP sets the standard for flexible laboratory solutions ...
... By incorporating a wide range of next-generation ... sets a new standard for flexible laboratory ... handling including pipetting, dilution, dispensing, and ... thats as powerful and flexible as it ...
BD Falcon, microtest ELISA plate 96 well flat-bottom, clear. Polystyrene, nonsterile, no lid (25/sp, 100/ca) Packaging: 25 / pack, 100 / case ...
Biology Products: