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NYU Cancer Institute experts present at American Society of Clinical Oncology annual meeting

ress after initial therapy. Recent research shows this VEGF inhibitor may encourage greater invasiveness in patients with newly diagnosed and recurrent HGGs. In the study, researchers assessed tumor recurrence patterns in HGGs and their relation to survival in newly-diagnosed patients treated with bevacizumab. A retrospective analysis was completed for patients with newly diagnosed HGGs initially treated with surgery, radiation therapy, and the drug- temozolomide. Patients were given bevacizumab at 10 mg/kg once every two weeks until disease progression or toxicity. Research shows bevacizumab improve progression free and overall survival in patients. However, researchers concluded there is a marked increase in the number of diffuse recurrences over local recurrences following the additional bevacizumab therapy treatment. This shift in the pattern to diffuse recurrence is worrisome to researchers. Future clinical trials are needed to investigate strategies to block this more invasive progression.

Abstract # 8571: Sunday, June 6 at 12:00 PM in Chicago, IL
Hair Depigmentation as an Indicator of Durable Response to CTLA-4 Therapy
Presenter: Anna C. Pavlick, MS, MD Associate Professor of Medicine and Ronald O. Perelman Department of Dermatology, Director, NYU Melanoma Program, NYU Cancer Institute

Treatment with Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) monoclonal antibodies for metastatic melanoma has been known to induce immunologically related adverse events like skin eruptions and itching in some patients. However, it was unclear if these events are linked with clinical responses. Researchers report, for the first time, the occurrence of hair depigmentation following therapy with CTLA-4 monoclonal antibodies correlates with durable clinical responses. No non-responders to the treatment developed any hair depigmentation. This is the first documentation of hair depigmentation following treatment with CTLA-4 monoclonal antibod

Contact: Lauren Woods
NYU Langone Medical Center / New York University School of Medicine

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