Date:5/21/2010

isorder (PTLD). This very uncommon condition involves the uncontrolled proliferation of lymphocytes, causing lymphoid malignancies. The majority of PTLD coincides with Epstein-Barr virus (EBV) driven B-cell proliferations. Although it is rare, T-cell monomorphic-PTLD (T-cell m-PTLD) has been observed. Due to the small number of patient cases ever reported, this rare lymphoma remains a poorly characterized and understood entity. Researchers report that to their knowledge this study includes the largest series of T-cell m-PTLD cases to be reported by a single institution. In the study, researchers analyzed and compared the prognosis of T-cell m-PTLD patients with B-cell m-PTLD patients, diagnosed and treated during the same time frame. Researchers believe some of the unique clinical features of T-cell m-PTLD include EBV negativity, late onset and advanced stage at diagnosis. However, the study shows that the less favorable prognosis of T-cell m-PTLD is independent of any of these factors. This suggests that these diseases may share the same poor risk biological features as their non-PTLD T-cell counterparts. The authors conclude that T-cell origin is an independent poor prognosis marker in PTLD.

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Abstract # 2020: Saturday, June 5 at 8:00 AM in Chicago, Illinois
Change in Pattern of Relapse in Newly Diagnosed High-Grade Glioma Following Bevacizumab Therapy
Presenter: Deborah Gruber, MD, clinical assistant professor, Department of Neurology, NYU Cancer Institute
Lead author: Michael Gruber, clinical professor, Departments of Neurology and Neurosurgery, NYU Cancer Institute

Vascular endothelial growth factor (VEGF) is found in endothelial cells of blood vessels and stimulates the growth of new blood vessels. When you have cancer, VEGF enables it to spread to other organs (metastasize). Bevacizumab is a VEGF inhibitor that has recently been approved by the FDA for the treatment of malignant high-grade gliomas (HGGs) that prog
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Contact: Lauren Woods lauren.woods@nyumc.org 212-404-3753 NYU Langone Medical Center / New York University School of Medicine Source:Eurekalert

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