Researchers investigated the molecular and genetic differences between the two most common melanoma subtypes: nodular melanoma and superficial spreading melanoma. Using an integrative genomic approach, researchers identified differences in genes related to the cellular metabolism between nodular melanoma and superficial spreading melanoma. Also, researchers identified genomic deletions that only occur in superficial spreading melanoma. These study results challenge the idea that nodular melanoma is a progression of superficial spreading melanoma, supporting the researchers' hypothesis that they are distinct biologic entities characterized by different molecular pathways. This finding emphasizes the importance of characterizing the genetic background of tumor subtypes rather than treating all melanoma as a homogenous entity. Researchers conclude that by identifying specific molecular defects that may contribute to the formation of the two most common subtypes of melanoma, they might be able to eventually develop subtype-specific treatments that are more specific and thus possibly more effective in treating one type of melanoma versus the other.
Abstract # 8056: Saturday, June 5 at 8:00 AM in Chicago, IL
T-Cell Monomorphic Post-Transplant Lymphoproliferative Disorders (T-Cell m-PTLD): Clinical Characteristics and Prognostic Assessment of a Serious Complication after Transplant
Presenter: Catherine Diefenbach, MD, assistant professor, Department of Medicine, NYU Cancer Institute
Lead author: Francesca Montanari, MD, Post Doctorate Research Fellow, NYU Cancer Institute
A serious complication after organ and bone marrow transplant is post-transplant lymphoproliferative d
|Contact: Lauren Woods|
NYU Langone Medical Center / New York University School of Medicine