Abstract # 8596: Sunday, June 6th at 8:00 AM in Chicago, IL
Prognostic Relevance of Increased Detection of Lymphovascular Invasion in Primary Melanoma Using D2-40 and CD34 Compared to Routine Histology
Presenter: Farbod Darvishian, MD, assistant professor, Department of Pathology, NYU School of Medicine
Lymphovascular invasion (LVI) in melanoma is the identification of tumor cells within the lymphatic vessels. The presence of melanoma tumor cells inside these vessels has been shown to be associated with poorer patient prognosis. This negative prognostic marker for melanoma patients can sometimes be difficult to detect using routine histology techniques. However, use of immunohistochemical markers such as D2-40 or CD34 can increase the number of cases of LVI identified, but the prognostic relevance of this increased detection has not previously been assessed. In a study of 246 melanoma patients, researchers show that LVI detected using these immunohistochemical markers is a better predictor of outcome than LVI detected by histology alone. Results suggest that in melanoma cases when LVI is reported, the use of D2-40 or CD34 should be considered. Authors conclude, the use of these two special stains that highlight the vessels, help physicians better detect more cases of LVI than with the current histology techniques. The increased number of cases of LVI detected using these stains is clinically relevant, and thus if LVI is reported, pathologists should consider using these markers in addition to the current standard technique.
Abstract # 8553: Sunday, June 6th at 8:00 AM in Chicago, IL
The Use of Integrative Genomics to Define Molecular Signatures of Melanoma Histologic Subtypes
|Contact: Lauren Woods|
NYU Langone Medical Center / New York University School of Medicine