NYU, American Museum of Natural History receive $1.6 million...(eer researchers to embark on genome-wide...)

Date:9/3/2008

eer researchers to embark on genome-wide structure predictions in a cost effective way. NYU biologists, headed by Bonneau, who holds an appointment in NYU's Courant Institute of Mathematical Sciences, have already obtained structure predictions for more than 150 genomes using the grid.

Proteins are synthesized in cells as long polymers that fold to form three-dimensional shapes critical for their function; knowledge of the three-dimensional structure of proteins can be crucial for inferring their specific function. The researchers will use multiple state-of-the-art methods for predicting protein structure from these protein sequences. These methods include "Rosetta," a computer program NYU researchers have previously used in predicting protein structure.

These methods will be especially useful for annotating the large fraction of proteins in plant genomes whose functions are currently unknown, the majority of which do not have any annotation of 3D folded structurethat is, no detectable similarity to another protein with a known structure. In this case annotating the proteins effectively means translating the gene sequence into predictions about the gene's function in the cell.

The project will be linked with a continuing education program for high school teachers at NYU's Steinhardt School for Culture, Education, and Human Development to train teachers how to incorporate bioinformatics into high school science curricula.

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Contact: James Devitt james.devitt@nyu.edu 212-998-6808 New York University Source:Eurekalert

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