Navigation Links
NYSCF scientists develop 3-D stem cell culture technique to better understand Alzheimer's disease
Date:4/2/2013

NEW YORK, NY (March 25, 2013) A team of researchers at The New York Stem Cell Foundation Research Institute led by Scott Noggle, PhD, Director of the NYSCF Laboratory and the NYSCF Charles Evans Senior Research Fellow for Alzheimer's Disease, and Michael W. Nestor, PhD, a NYSCF Postdoctoral Research Fellow, has developed a technique to produce three-dimensional cultures of induced pluripotent stem (iPS) cells called embryoid bodies, amenable to live cell imaging and to electrical activity measurement. As reported in their Stem Cell Research study, these cell aggregates enable scientists to both model and to study diseases such as Alzheimer's and Parkinson's disease.

The NYSCF Alzheimer's disease research team aims to better understand and to find treatments to this disease through stem cell research. For such disorders in which neurons misfire or degenerate, the NYSCF team creates "disease in a dish" models by reprogramming patients' skin and or blood samples into induced pluripotent stem (iPS) cells that can become neurons and the other brain cells affected in the diseases.

The cells in our body form three-dimensional networks, essential to tissue function and overall health; however, previous techniques to form complex brain tissue resulted in structures that, while similar in form to naturally occurring neurons, undermined imaging or electrical recording attempts.

In the current study, the Noggle and Nestor with NYSCF scientists specially adapted two-dimensional culture methods to grow three-dimensional neuron structures from iPS cells. The resultant neurons were "thinned-out," enabling calcium-imaging studies, which measure the electrical activity of cells like neurons.

"Combining the advantages of iPS cells grown in a 3D environment with those of a 2D system, our technique produces cells that can be used to observe electrical activity of putative networks of biologically active neurons, while simultaneously imaging them," said Nestor. "This is key to modeling and studying neurodegenerative diseases."

Neural networks, thought to underlie learning and memory, become disrupted in Alzheimer's disease. By generating aggregates from iPS cells and comparing these to an actual patient's brain tissue, scientists may uncover how disease interferes with these cell-to-cell interactions and understand how to intervene to slow or stop Alzheimer's disease.

"This critical new tool developed by our Alzheimer's team will accelerate Alzheimer's research, enabling more accurate manipulation of cells to find a cure to this disease," said Susan L. Solomon, CEO of NYSCF.


'/>"/>

Contact: David McKeon
dmckeon@nyscf.org
212-365-7440
New York Stem Cell Foundation
Source:Eurekalert

Related biology news :

1. UGA discovery may allow scientists to make fuel from CO2 in the atmosphere
2. UT MD Anderson scientists uncover the nuclear life of actin
3. Scientists awarded £3M to study the way Northwest European seas absorb carbon
4. Scientists reveal quirky feature of Lyme disease bacteria
5. Scientists create new tools for battling secondhand smoke
6. Academy scientists receive top honors for long-term research and training initiatives in Mongolia
7. Scientists discover reasons behind snakes shrinking heads
8. U of T scientists map genome that causes Dutch Elm Disease
9. Scientists discover novel chemical that controls cell behavior
10. 87 scientists elected to the American Academy of Microbiology
11. New book celebrates women scientists in the Americas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... 30, 2017  On April 6-7, 2017, Sequencing.com will ... hackathon at Microsoft,s headquarters in ... focus on developing health and wellness apps that provide ... the Genome is the first hackathon for personal ... largest companies in the genomics, tech and health industries ...
(Date:3/30/2017)... Trends, opportunities and forecast in this market ... (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, vein ... use industry (government and law enforcement, commercial and retail, ... others), and by region ( North America ... Pacific , and the Rest of the World) ...
(Date:3/28/2017)... PUNE, India , March 28, 2017 ... (Analog, IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), ... Maintenance), Vertical, and Region - Global Forecast to 2022", ... 30.37 Billion in 2016 and is projected to reach ... 15.4% between 2017 and 2022. The base year considered ...
Breaking Biology News(10 mins):
(Date:6/26/2017)... PA (PRWEB) , ... June 26, 2017 , ... Two ... its annual Shareholders Meeting on June 9, 2017: Jeremy Nowak, President, J Nowak Strategy ... Science Center also announced the election of Glen N. Gaulton and Kenneth L. Kring, ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... for model aircraft flying hobbyists, and the University Aviation Association (UAA), the unifying ... students. The UAS4STEM Collegiate Challenge will encourage teamwork, competition, and success through a ...
(Date:6/22/2017)... ... June 22, 2017 , ... Ovation Fertility supports the American ... bringing new hope for prospective parents who are challenged with costs of treatment. ... World Health Organization’s designation in hopes of changing the way health insurers, governments ...
(Date:6/22/2017)... ... ... Charm Sciences, Inc. is pleased to announce that its Charm Amphenicol (AMPH) test ... screening test at dairies and farms for raw commingled cow milk. The test was ... system. These systems are a combination incubator and reader in one. , “The AMPH ...
Breaking Biology Technology: