Navigation Links
NYSCF scientists develop 3-D stem cell culture technique to better understand Alzheimer's disease
Date:4/2/2013

NEW YORK, NY (March 25, 2013) A team of researchers at The New York Stem Cell Foundation Research Institute led by Scott Noggle, PhD, Director of the NYSCF Laboratory and the NYSCF Charles Evans Senior Research Fellow for Alzheimer's Disease, and Michael W. Nestor, PhD, a NYSCF Postdoctoral Research Fellow, has developed a technique to produce three-dimensional cultures of induced pluripotent stem (iPS) cells called embryoid bodies, amenable to live cell imaging and to electrical activity measurement. As reported in their Stem Cell Research study, these cell aggregates enable scientists to both model and to study diseases such as Alzheimer's and Parkinson's disease.

The NYSCF Alzheimer's disease research team aims to better understand and to find treatments to this disease through stem cell research. For such disorders in which neurons misfire or degenerate, the NYSCF team creates "disease in a dish" models by reprogramming patients' skin and or blood samples into induced pluripotent stem (iPS) cells that can become neurons and the other brain cells affected in the diseases.

The cells in our body form three-dimensional networks, essential to tissue function and overall health; however, previous techniques to form complex brain tissue resulted in structures that, while similar in form to naturally occurring neurons, undermined imaging or electrical recording attempts.

In the current study, the Noggle and Nestor with NYSCF scientists specially adapted two-dimensional culture methods to grow three-dimensional neuron structures from iPS cells. The resultant neurons were "thinned-out," enabling calcium-imaging studies, which measure the electrical activity of cells like neurons.

"Combining the advantages of iPS cells grown in a 3D environment with those of a 2D system, our technique produces cells that can be used to observe electrical activity of putative networks of biologically active neurons, while simultaneously i
'/>"/>

Contact: David McKeon
dmckeon@nyscf.org
212-365-7440
New York Stem Cell Foundation
Source:Eurekalert

Page: 1 2

Related biology news :

1. UGA discovery may allow scientists to make fuel from CO2 in the atmosphere
2. UT MD Anderson scientists uncover the nuclear life of actin
3. Scientists awarded £3M to study the way Northwest European seas absorb carbon
4. Scientists reveal quirky feature of Lyme disease bacteria
5. Scientists create new tools for battling secondhand smoke
6. Academy scientists receive top honors for long-term research and training initiatives in Mongolia
7. Scientists discover reasons behind snakes shrinking heads
8. U of T scientists map genome that causes Dutch Elm Disease
9. Scientists discover novel chemical that controls cell behavior
10. 87 scientists elected to the American Academy of Microbiology
11. New book celebrates women scientists in the Americas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... -- higi, a leading cloud-based consumer engagement platform that provides ... their communities around health and wellness, announced today the ... ... convenient vehicle to receive validated health information from consumers. ... API will allow higi,s trusted partners, on a user ...
(Date:4/2/2015)... Germany , April 2, 2015 ... fingerprint tests DERMALOG by far outperforms the strongest ... always maintaining high accuracy, the system is capable ... Hence, the speed proves up to be ten ... faster than its runner-up performance.      ...
(Date:4/1/2015)... , April 1, 2015   Medisafe ™, ... million users across iOS and Android ... begun integrating biofeedback into the platform to allow patients ... outcomes. For the first time, patients will be able ... a dose impacts important biometrics, such as glucose levels ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2
... at UCLA,s Jonsson Comprehensive Cancer Center have modified a common ... Tomography (PET), an advance that will allow them to model ... to new therapies. The discovery, published June 8, 2008 ... enables scientists to monitor the immune system at the ...
... Communication,Intelligence Corporation (the "Company") (OTC Bulletin Board: CICI), ... process,automation in the financial industry and the recognized ... has closed a financing, on,June 5, 2008, led ... As part of the financing, the Company borrowed ...
... ANN ARBOR, Mich.---Developing fundamental math and mechanics to explain ... could open doors to a new frontier in biology, ... and engineers will gather in Woods Hole, Mass. June ... Mechanics. The University of Michigan is leading the organization ...
Cached Biology News:UCLA researchers develop new PET scanning probe that will allowing monitoring of the immune system 2UCLA researchers develop new PET scanning probe that will allowing monitoring of the immune system 3Communication Intelligence Corporation Closes $3.6 Million Financing 2Communication Intelligence Corporation Closes $3.6 Million Financing 3Communication Intelligence Corporation Closes $3.6 Million Financing 4Forum to focus on math and mechanics behind life processes 2Forum to focus on math and mechanics behind life processes 3
(Date:5/5/2015)... May 5, 2015  Tikcro Technologies Ltd. (OTCQB: ... to continue trading on OTCQB  Marketplace, the market ... Marketplace allows for a continuous public market for ... have real-time quotes and market information on us ... OTCQB Marketplace includes U.S. and international companies in ...
(Date:5/5/2015)... 2015  Renova™ Therapeutics, a biopharmaceutical company developing ... other chronic diseases, has engaged RAND Health Advisory ... reflect the healthcare patterns of multiple advanced heart ... used to characterize the impact the company,s lead ... groups of patients and the overall health care ...
(Date:5/5/2015)... 2015 ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") (NYSE ... President and Chief Executive Officer, will present live ... DATE:  Thursday, May 7, 2015     TIME:  11:30 am ET/8:30 ... click the red "register/ watch presentations" button ... event where investors are invited to ask the ...
(Date:5/5/2015)... WASHINGTON, D.C., USA (PRWEB) May 05, 2015 ... export regulations covering a wide range of key photonics ... are hampering global competitiveness of U.S. industry. To help ... webinar on 12 May on the proposed ... governs the commodities covered by International Traffic in Arms ...
Breaking Biology Technology:Tikcro Technologies Announces Approval to Continue Trading on OTCQB 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 3ImmunoCellular Therapeutics to Webcast Live at VirtualInvestorConferences.com on May 7 2Comments needed now from photonics industry on revisions of U.S. export rules 2Comments needed now from photonics industry on revisions of U.S. export rules 3Comments needed now from photonics industry on revisions of U.S. export rules 4
... -- UW-Madison Civil and Environmental Engineering professor ... have both received approximately $40,000 from the John ... innovative teaching approaches. , ,Cramer, professor Hussain Bahia, ... Media Services will convert the three-credit Materials for ...
... Wis. -- Paragon Development Systems is poised for ... office to house the company's 24/7 service desk, the ... which is an IT infrastructure services provider, officially unveiled ... the space at 361 Blettner Blvd. in June. , ...
... has joined the board of directors of Neurognostics, ... which spun out of the Medical College of Wisconsin ... services , ,Silva-Craig is the president and chief operating ... 2001. Emageon provides medical image management software ...
Cached Biology Technology:UW professors get grants to engage technology for course delivery 2PDS sees Madison facility as launchpad for growth 2PDS sees Madison facility as launchpad for growth 3