Navigation Links
NYSCF scientists develop 3-D stem cell culture technique to better understand Alzheimer's disease
Date:4/2/2013

NEW YORK, NY (March 25, 2013) A team of researchers at The New York Stem Cell Foundation Research Institute led by Scott Noggle, PhD, Director of the NYSCF Laboratory and the NYSCF Charles Evans Senior Research Fellow for Alzheimer's Disease, and Michael W. Nestor, PhD, a NYSCF Postdoctoral Research Fellow, has developed a technique to produce three-dimensional cultures of induced pluripotent stem (iPS) cells called embryoid bodies, amenable to live cell imaging and to electrical activity measurement. As reported in their Stem Cell Research study, these cell aggregates enable scientists to both model and to study diseases such as Alzheimer's and Parkinson's disease.

The NYSCF Alzheimer's disease research team aims to better understand and to find treatments to this disease through stem cell research. For such disorders in which neurons misfire or degenerate, the NYSCF team creates "disease in a dish" models by reprogramming patients' skin and or blood samples into induced pluripotent stem (iPS) cells that can become neurons and the other brain cells affected in the diseases.

The cells in our body form three-dimensional networks, essential to tissue function and overall health; however, previous techniques to form complex brain tissue resulted in structures that, while similar in form to naturally occurring neurons, undermined imaging or electrical recording attempts.

In the current study, the Noggle and Nestor with NYSCF scientists specially adapted two-dimensional culture methods to grow three-dimensional neuron structures from iPS cells. The resultant neurons were "thinned-out," enabling calcium-imaging studies, which measure the electrical activity of cells like neurons.

"Combining the advantages of iPS cells grown in a 3D environment with those of a 2D system, our technique produces cells that can be used to observe electrical activity of putative networks of biologically active neurons, while simultaneously i
'/>"/>

Contact: David McKeon
dmckeon@nyscf.org
212-365-7440
New York Stem Cell Foundation
Source:Eurekalert

Page: 1 2

Related biology news :

1. UGA discovery may allow scientists to make fuel from CO2 in the atmosphere
2. UT MD Anderson scientists uncover the nuclear life of actin
3. Scientists awarded £3M to study the way Northwest European seas absorb carbon
4. Scientists reveal quirky feature of Lyme disease bacteria
5. Scientists create new tools for battling secondhand smoke
6. Academy scientists receive top honors for long-term research and training initiatives in Mongolia
7. Scientists discover reasons behind snakes shrinking heads
8. U of T scientists map genome that causes Dutch Elm Disease
9. Scientists discover novel chemical that controls cell behavior
10. 87 scientists elected to the American Academy of Microbiology
11. New book celebrates women scientists in the Americas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/25/2014)... that promotes virus entry into cells also has the ... viruses, University of Missouri researchers have found. , "This ... our understanding of not only HIV infection, but also ... M.D., Ph.D., associate professor in the MU School of ... study was recently published in the Proceedings of ...
(Date:8/25/2014)... reproduces by manipulating the behavior of ants emits ... brain of its natural target host, but not ... shows., The findings, which suggest that the fungus ... the molecular mechanisms underlying this phenomenon, according to ... to secrete chemicals that affect their environment," noted ...
(Date:8/25/2014)... 25, 2014 Riddell, the leader in football ... Research Institute (TGen), a leader in cutting-edge genomic ... University and its Sun Devil football program will ... to advance athlete concussion detection and treatment. , ... project will combine molecular information and head impact ...
Breaking Biology News(10 mins):MU researchers discover protein's ability to inhibit HIV release 2MU researchers discover protein's ability to inhibit HIV release 3Zombie ant fungi 'know' brains of their hosts 2Zombie ant fungi 'know' brains of their hosts 3Riddell, TGen team with ASU football to further genetic research into concussion detection 2Riddell, TGen team with ASU football to further genetic research into concussion detection 3
... Harvard Medical School (HMS) report in the April 23 ... encode the values that subjects assign to different items. ... of decision-making that occurs when someone chooses between different ... in various parts of the brain respond to separate ...
... up to $10.3 million to help develop a new prosthetic arm ... Utah work is a key part of a U.S. Department of ... device for soldiers and potentially others whose arms were amputated. , ... thoughts, that allows you to feel both the outside world and ...
... depression by manipulating the neurotransmitter serotonin in the brain ... that are not yet understood, say scientists from Georgetown ... That's because the investigators found, for the first time, ... immune system, and that the chemical is specifically used ...
Cached Biology News:Attention shoppers: Researchers find neurons that encode the value of different goods 2Attention shoppers: Researchers find neurons that encode the value of different goods 3Both alcoholism and chronic smoking can damage the brain's prefrontal cortex 2Both alcoholism and chronic smoking can damage the brain's prefrontal cortex 3Both alcoholism and chronic smoking can damage the brain's prefrontal cortex 4Both alcoholism and chronic smoking can damage the brain's prefrontal cortex 5Commonly used antidepressants may also affect human immune system 2Commonly used antidepressants may also affect human immune system 3
(Date:8/27/2014)... August 27, 2014 Riviera Beach, ... announcing the creation of the Sancilio Scientific Advisory ... the SCI’s philosophy of looking to nature for ... development actions are based on sound scientific data, ... Advisory Board provides a vehicle for SCI to ...
(Date:8/27/2014)... State College, PA (PRWEB) August 27, 2014 ... Electromagnetic Simulation Software with new features for the ... release is an enhanced Biological Thermal Sensor, exclusive to ... is a specialty version of XFdtd, developed to calculate ... MATLAB® export functionality has been added to all versions ...
(Date:8/26/2014)... 2014  NeuroSigma, Inc., a Los Angeles ... technologies, today announced that it has filed a registration ... Exchange Commission relating to a proposed initial public offering ... be offered and the price range for the proposed ... LLC will act as the book-running manager for the ...
(Date:8/26/2014)... 2014 - A team of engineers from Singapore ... sensor network (WSN) for satellite communications. , With ... in satellite design, constructing a lightweight, low power-consuming, ... inside the satellite has always been a challenge ... the Satellite Research Centre of Nanyang Technological University ...
Breaking Biology Technology:New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 2Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 3ZigBee in the Sky 2
... HAVEN, Conn., Sept. 9 Rib-X Pharmaceuticals, ... focused on the,discovery and development of novel ... today the formation of its,Clinical Advisory Board. ... will provide oversight and counsel on matters ...
... announces the,availability of MarketStats for agri-biotech equities ... offers a perspective on the,aforementioned equities and ... blogs and opinions., Investors can view ... division of FiSpace.net, a dynamic social networking ...
... Affitech AS, the Norwegian,antibody therapeutics company, today announced ... Chairman of its Board of Directors. The,Company,s previous ... of the,Board. Mr Broymer welcomed Dr McCullagh,s appointment ... McCullagh has agreed to take over from me ...
Cached Biology Technology:Rib-X Pharmaceuticals, Inc. Announces Formation of Clinical Advisory Board 2Rib-X Pharmaceuticals, Inc. Announces Formation of Clinical Advisory Board 3SectorWatch.biz Issues MarketStats on Agri-Biotech Equities YGYB, GRO, SEED, MON, ADM, and BG 2Affitech Appoints Dr. Keith McCullagh as Chairman 2Affitech Appoints Dr. Keith McCullagh as Chairman 3
...
Cell Lysis Buffer is used to lyse cells under nondenaturing conditions....
LECHNER AND LaVECK MEDIUMfor the clonal growth of normal human bronchial and other epithelial cells. Requires additives. With glutamine.Recommended storage condition:oC to 8oCIntended use(s):research...
...
Biology Products: