Navigation Links
NTU researchers complete the world's first in-depth study of the malaria parasite genome

Groundbreaking research done at Singapore's Nanyang Technological University's (NTU) School of Biological Sciences (SBS) could lead to the development of more potent drugs or a vaccine for malaria, which is transmitted to humans by infected mosquitoes and kills up to three million people each year.

Assistant Professor Zbynek Bozdech and his team of researchers, including graduate students and post-doctorals from SBS' Division of Genomics & Genetics, have scored a world first in successfully using transcriptional profiling to uncover hitherto unknown gene expression (activity) patterns in malaria.

The research team's breakthrough made the January 2010 edition of the top-ranked journal, Nature Biotechnology, which is a satellite publication of Nature, the world's leading peer-reviewed journal.

Transcriptional profiling is the measurement of the activity of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment.

This outcome in infectious disease pathology could potentially be the decade's big breakthrough as it has yielded critical information about how the malaria parasite Plasmodium falciparum the most deadly form of malaria responds to existing compounds with curative potential.

The genome or the complete DNA content of the Plasmodium falciparum has about 5,300 genes. Up till now, scientists have a good understanding of the gene functions for only about half of the more than 5,000 genes. Using transcriptional profiling, Asst Prof Zbynek Bozdech's team has successfully uncovered the gene functions for almost the entire genome, with more than 90 percent of the gene functions from the previously unknown half now better understood.

"Drawing on our findings, pharmaceutical companies could explore ways to design a drug that targets the weakest link," said Asst Prof Bozdech of his research which was supported with S$900,000 in grants from Singapore's Ministry of Education and the National Medical Research Council. "We have predicted all the genes that could be used for a vaccine as well," he said.

Researchers at Germany's renowned institute for tropical diseases, the Bernhard Nocht Institute for Tropical Medicine, have validated the research findings, which are expected to provide exciting new insights into parasite biology.

"The successful NTU-BNI joint project has led to the creation of the world's first database to predict the functions of more than 2,500 genes of the malaria parasite previously unknown. The database would be useful to scientists around the world who are developing new vaccines and drugs," says Dr. Tim Gilberger, Head, Malaria Research at BNI.

Preventing malaria infection is important because resistance to anti-malarial drugs is a growing problem worldwide. There is currently no vaccine for malaria, which is widespread in poorer countries where it remains a hindrance to economic development. Also of growing concern to scientists is the confirmation of the first signs of resistance to the only affordable treatment left in the global medicine cabinet for malaria: Artemisinin.

In successfully using transcriptional profiling to study the behavior of the malaria parasite, NTU's researchers have ventured into the unknown and paved the way for future breakthroughs in healthcare.

"The wealth of new information arising from our extensive four-year study is a major contribution to the worldwide effort to better understand and treat malaria," said Prof Peter Rainer Preiser, Deputy Director of NTU's BioSciences Research Centre and a member of the NTU research team.


Contact: Hisham Hambari
Nanyang Technological University

Related biology news :

1. Yale researchers may have uncovered the mechanism by which progesterone prevents preterm birth
2. Secrets to superb malting barleys explored by ARS researchers
3. UF researchers: Ancient crocodile relative likely food source for Titanoboa
4. ARS researchers develop method to speed up breeding of scab-resistant barley cultivars
5. National Jewish Health researchers discover how virulent bacteria
6. Epigenetics could help researchers determine any risks associated with low-dose radiation
7. University of the Basque Country researchers decode transcriptome for gray mullet
8. Researchers correct the record about behavior of important human protein tied to cancer
9. Bat researchers no longer flying blind on echolocation
10. Researchers trace effects of genetic defect in myotonic muscular dystrophy
11. Researchers identify a new gene involved in autophagy, the cellular recycling program
Post Your Comments:
(Date:5/12/2016)... 12, 2016 , a brand ... overview results from the Q1 wave of its quarterly ... was consumers, receptivity to a program where they would ... health insurance company. "We were surprised to ... Michael LaColla , CEO of Troubadour Research, "primarily ...
(Date:4/28/2016)... India , April 28, 2016 ... Infosys (NYSE: INFY ), and Samsung SDS, a ... that will provide end customers with a more secure, ... services.      (Logo: ) , ... services, but it also plays a fundamental part in enabling ...
(Date:4/26/2016)... Research and Markets has announced ... 2016-2020"  report to their offering.  , ,     (Logo: ... analysts forecast the global multimodal biometrics market to ... period 2016-2020.  Multimodal biometrics is being ... the healthcare, BFSI, transportation, automotive, and government for ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... /PRNewswire/ - FACIT has announced the creation of ... company, Propellon Therapeutics Inc. ("Propellon" or "the Company"), ... portfolio of first-in-class WDR5 inhibitors for the treatment ... represent an exciting class of therapies, possessing the ... cancer patients. Substantial advances have been achieved with ...
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... Ky. , June 23, 2016 ... two Phase 1 clinical trials of its complement ... placebo-controlled, single and multiple ascending dose studies designed ... pharmacodynamics (PD) of subcutaneous injection in healthy adult ... subcutaneously (SC) either as a single dose (ranging ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® Inc. (RCA), ... free webinar on Performing Quality Investigations: Getting to Root Cause. ... no charge. , Incomplete investigations are still a major concern to the Regulatory ...
Breaking Biology Technology: