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NTU professor discovers method to efficiently produce less toxic drugs using organic molecules
Date:7/8/2009

Nanyang Technological University (NTU)'s Associate Professor Zhong Guofu has made a significant contribution to the field of organic chemistry, in particular the study of using small organic molecules as catalysts, in the synthesis process called organocatalysis. Such synthesis process takes place for example, during the production of chiral drugs.

In his study, Professor Zhong, who is from NTU's School of Physical and Mathematical Sciences, has successfully created the first example where an organocatalyst is able to be 'recycled' (i.e. multiple reactions achieved with the recycled catalyst) during the synthesis process thus increasing its yield/effectiveness. Previously no one has been able to 'recycle' the organocatalysts directly (i.e. only single reactions performed) leading to the limitation of the use of organocatalysis in the industry.

This ability to 'recycle' and produce multiple reactions thus increases the efficacy of the organocatalysis, making it a more efficient process, something that has not been demonstrated before. It also means that fewer chemicals are used in the synthesis process, making it a far more 'green' and less toxic process.

Professor Zhong has written a paper on his discovery, which has been published in a recent edition of the scientific journal ChemComm.

The study of organocatalysis using organic molecules (which exists in nature, e.g. protein, amino acids) is a relatively new idea that started less than 10 years ago. The present dominant catalysts used in such synthesis process are 'ligand-metal catalysts' (such as ligand-copper, -palladium, -platinum, -ruthenium etc). However when compared to organocatalysts, ligand-metal catalysis is considered less 'green' and thus more 'toxic'.

However, the problem with using organocatalysts is that it is usually not an efficient or cost effective process since relatively a high catalyst loading is needed, compared to ligand-metal catalysis.


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Contact: Hisham Hambari
mhisham@ntu.edu.sg
656-790-6447
Nanyang Technological University
Source:Eurekalert

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