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NTP finalizes report on Bisphenol A
Date:9/3/2008

a five-level scale ranging from negligible to serious, with "some concern" being the midpoint.

"We are expressing this level of concern because we see developmental changes occurring in some animal studies at BPA exposure levels similar to those experienced by humans," Bucher said.

The report also expresses "minimal concern" that BPA exposure will affect development of the mammary gland or accelerate puberty in females. The NTP expressed "negligible concern" that exposure of pregnant woman to BPA will result in fetal or neonatal mortality, birth defects or reduced birth weight and growth in their offspring.

The NTP also expressed "negligible concern" that exposure to BPA causes reproductive effects in non-occupationally exposed adults and "minimal concern" for workers exposed to higher levels in occupational settings.

"The literature on experimental animal studies is large and filled with many conflicting findings. There are a number of remaining uncertainties in the scientific information on BPA," said Bucher. The report discusses many of the uncertainties, including the very limited data from studies in humans and the difficulty in relating the often subtle developmental endpoints in animal studies to human health risks.

The NTP Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted the BPA evaluation. The CERHR follows a formal process for review and evaluation of nominated chemicals that includes convening panels of scientific experts to review the world's scientific literature on the chemical being studied and a peer review process, as well as numerous opportunities for public input. For a summary of the NTP evaluation of BPA, please see http://www.niehs.nih.gov/news/media/questions/sya-bpa.cfm#4.

CERHR publishes monographs that assess the evidence that environmental chemicals, physical substances, or mixtu
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Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert

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