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NSF funds innovative approach to biomimetic nanofiber bone regeneration
Date:8/4/2010

the small cortical bone repeating units, these biomimetic scaffolds offer large surface areas and well-interconnected pores for nutrient transport and cell penetration, and more importantly, provide a biomimetic cell-friendly microenvironment to facilitate the bone tissue formation, needed for successful repair of large bone defects.

"The results of Dr. Wang's research will have a far‐reaching impact on tissue engineering," says Dr. Michael Bruno, Dean of the Schaefer School of Engineering and Science. "The wealth of basic and applied knowledge learned at Stevens will lay the foundation for our long‐term research efforts and the development of real-world applications."

Over the next three years, Dr. Wang's research team plan to make substantial strides in synergistically integrating nanobiomaterials with bone tissue engineering for the creation of cortical bone with hierarchical structure and functional complexity.

We hope to establish a family of biomimetic nanofibers containing collagen and calcium phosphate to support the phenotype of bone‐forming cells; new practical approaches to creating osteon‐like units using biomimetic nanofibers and osteoblasts; formulation of calcium phosphate containing collagen gel for bone tissue formation; and most importantly, an innovative approach to generating cortical‐like bone by assembling osteon‐like structures into one fused construct," explains Dr. Wang.

"The intellectually rich environment established by Dr. Wang and his team is inspiring to our graduate and undergraduate students who are participating in the transformative benefits of cutting-edge research and its profound application," says Dr. Philip Leopold, Director of the Department of Chemistry, Chemical Biology and Biomedical Engineering.

For more information on Stevens Pioneering Bone Regeneration research, please contact Dr. Wang: http://www.stevens.edu/research/research_profile.ph
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Contact: Dr. Hongjun Wang
Hongjun.Wang@stevens.edu
201-216-5556
Stevens Institute of Technology
Source:Eurekalert

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