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NSAIDs benefit overweight breast cancer patients, study finds
Date:8/14/2014

NSAIDs with those who did not.

The researchers designed a second study to examine how breast cancer cells behave in the body. By bathing ERα positive breast cancer cells in blood serum from obese women, they hoped to mimic the environment that encourages tumors to grow, proliferate and metastasize.

Although the mechanism causing breast cancer in obese women to be more aggressive and less responsive to treatment is not completely understood, the researchers believe that inflammation plays a pivotal role. Their findings also suggest inflammation negatively affects the effectiveness of aromatase inhibitors, a class of cancer drugs commonly prescribed to prevent cancer recurrence.

"Clinicians are finding that the five-year recurrence rate for postmenopausal women is much higher on aromatase inhibitors when the patient is obese," says deGraffenried. "We would like to identify which women are most likely to benefit from interventions like adding NSAIDs to treatment regimens."

Laura Bowers, who led the cell culture segment of the study, suggests that overweight or obese postmenopausal women those at greater risk for breast cancer development might benefit from taking a low-dose aspirin daily. "What this study does is present great promise that a fairly inexpensive and nontoxic agent might benefit obese and overweight breast cancer patients who are at a higher risk of aromatase inhibitor failure but further studies are needed to confirm these results," says Bowers.

The research team is planning a larger prospective study to identify disease biomarkers and monitor patient response to the addition of NSAIDs to breast cancer treatment.


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Contact: Kimberly Atkins
kimberly.atkins@austin.utexas.edu
512-471-3151
University of Texas at Austin
Source:Eurekalert

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