Navigation Links
NSAIDs benefit overweight breast cancer patients, study finds
Date:8/14/2014

AUSTIN, Texas Researchers have determined that postmenopausal overweight or obese breast cancer patients receiving hormone therapy as part of their treatment and who use nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen have significantly lower breast cancer recurrence rates and a sizable delay in time to cancer recurrence.

The findings, published in the Aug. 14 edition of Cancer Research, suggest a new possibility for reducing the incidence of breast cancer recurrence among overweight and obese postmenopausal women, who have a comparatively higher risk of recurrence.

Using a retrospective analysis of human subjects and cell cultures, the researchers determined that NSAID use reduces the recurrence rate of the most common form of breast cancer, ERα positive breast cancer, by 50 percent and extends patients' disease-free period by more than two years. ER positive breast cancers, which grow in response to exposure to the hormone estrogen, account for about 75 percent of diagnoses.

Cancer researcher Linda deGraffenried of The University of Texas at Austin designed the study, working closely with Andrew Brenner, an oncologist from the Cancer Therapy & Research Center at The University of Texas Health Science Center at San Antonio, and Murali Beeram, a cancer specialist from the START Center for Cancer Care in San Antonio, Texas.

The investigators caution that these results are preliminary, and studies are being conducted to confirm these initial findings.

"Overweight or obese women diagnosed with breast cancer are facing a worse prognosis than normal-weight women," says deGraffenried. "We believe that obese women are facing a different disease. There are changes at the molecular level. We seek to modulate the disease promoting effects of obesity."

The investigators first examined medical records of 440 breast cancer patients, comparing the prognoses of those who took
'/>"/>

Contact: Kimberly Atkins
kimberly.atkins@austin.utexas.edu
512-471-3151
University of Texas at Austin
Source:Eurekalert

Page: 1 2

Related biology news :

1. Patients use OTC NSAIDs even when they have a high risk of serious side effects
2. Artificial wetlands can provide benefits over the long haul
3. Strong scientific evidence that eating berries benefits the brain
4. Consumers need simple, concise messages about benefits of phytonutrients
5. Sexual reproduction brings long-term benefits, study shows
6. Why letting salmon escape could benefit bears and fishers
7. Treatment to benefit African infants at risk of endemic fever
8. New research underscores the health benefits of fibers, including bone health
9. How will the US biotechnology industry benefit from new patent laws?
10. NHS set to benefit from UK-led technologies
11. Targeting tuberculosis hotspots could have widespread benefit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/17/2015)...  MecklerMedia Corporation (OTCQX: MECK) announced its ... ever held in New York City ... 2015 at the Javits Convention Center. ... Acorn Product Development; Axis NJ; c-Link Systems; CoroWare; ... NewBotic Corporation; Neya Systems LLC; Reliabotics; RoboKind; RocketFarm ...
(Date:3/12/2015)... MOUNTAIN VIEW, Calif. , March 12, 2015 ... EDTLOCATION:Online, with Complimentary Registration here: http://bit.ly/1G7Os0L . ... Program Manager Aravind SeshagiriPhoto - http://photos.prnewswire.com/prnh/20150311/181111 ... future in order to compete in several different ... the market is currently witnessing an uptrend. ...
(Date:3/10/2015)... --  Tute Genomics , pioneer in affordable, accurate and ... company PrimBio Research Institute to be its ... interpretation. PrimBio, a certified Life Technologies Ampliseq ... to support the work of experts on the front ... of exome sequencing services: 1) Targeted Exome and 2) ...
Breaking Biology News(10 mins):MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 2Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 3PrimBio Research Selects Tute as Whole Exome Analysis Provider, Creating Integrated, End-to-End Solution for Next-Generation Sequencing & Data Analysis 2PrimBio Research Selects Tute as Whole Exome Analysis Provider, Creating Integrated, End-to-End Solution for Next-Generation Sequencing & Data Analysis 3
... about selective serotonin reuptake inhibitors (SSRIs) suggests that these ... like depression and anxiety, have multiple effects on our ... 2010 issue of GENETICS ( http://www.genetics.org ), ... or pathways affected by SSRIs. Such secondary pathways could ...
... at the Buck Institute for Age Research have successfully ... rodents afflicted with Parkinson,s Disease (PD). The research, ... had previously developed, can be used to manufacture the ... paves the way for the use of iPSC,s in ...
... is now clear that RNA plays a major role in ... while also serving as an important tool in functional genomics. ... Review series is providing RNA experts and researchers not only ... also a framework to generate new insights and applications. ...
Cached Biology News:SSRIs may pack more punch at the cellular level than believed 2Scientists successfully use human induced pluripotent stem cells to treat Parkinson's in rodents 2
(Date:3/27/2015)...  Neogen Corporation (NASDAQ: NEOG ) announced today ... plan in accordance with Securities and Exchange Commission rule ... Neogen Corporation, is a minority owner of this entity ... Herbert does not have control of this entity, ... only for a portion of the shares owned by ...
(Date:3/27/2015)... 27, 2015  CASI Pharmaceuticals, Inc. (Nasdaq: CASI ... and commercialization of innovative therapeutics addressing cancer and other ... commercial focus on China , today ... ended December 31, 2014.  The Company ... per share, for the three months ended December 31, ...
(Date:3/26/2015)... March 26, 2015 The Market Element ... a strategic alliance with Designing Gig LLC to provide ... , “Forging this alliance with Designing Gig ... we can extend a comprehensive, end-to-end, digital solution for ... and execution,” said Chuck Miller, president of The Market ...
(Date:3/26/2015)... March 26, 2015 ReliantHeart, Inc., an ... Transonic, a supplier of precision transit-time flow measurement solutions, ... greatly improve the efficiency of the HeartAssist5® ... patients to experience greater mobility and peace of mind. ... miniature flow board, will draw 1/6th of the power ...
Breaking Biology Technology:Neogen CEO adopts 10b5-1 Trading Plan 2CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 2CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 4CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 5CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 6The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3
... designed to help consulting engineers and other ... GROVE, Ill., April 8 Siemens Building ... Science Solutions Design Guide written expressly for ... looking to design and specify effective and ...
... Kiadis,Pharma reported preliminary clinical data on ATIR(TM) ... Data was presented by the,company,s principal investigator ... Symposium at the Annual European Bone Marrow ... March 30, 2009. Only the 6,highest ranked ...
... Micromet, Inc. (Nasdaq: MITI ), a ... treatment of cancer, inflammation and autoimmune diseases, today ... Journal of Immunotherapy (1) demonstrating the potent anti-tumor ... antigen (CEA) and to CD3 on T cells. ...
Cached Biology Technology:Siemens Offers Life Science Solutions Design Guide for Consulting Engineers 2Kiadis Pharma Reports ATIR(TM) Clinical Data, Further Supporting its Potential in Mismatched Bone Marrow Transplantations 2Pre-Clinical Data on CEA-specific BiTE Antibody Published in Journal of Immunotherapy Demonstrate Potent Control of Tumor Growth 2Pre-Clinical Data on CEA-specific BiTE Antibody Published in Journal of Immunotherapy Demonstrate Potent Control of Tumor Growth 3Pre-Clinical Data on CEA-specific BiTE Antibody Published in Journal of Immunotherapy Demonstrate Potent Control of Tumor Growth 4
... is used for single-color real-time detection using ... JOE fluorophores and features a real-time PCR ... from 96 wells, a gene expression macro ... The system includes the optical module and ...
... , CapSure HS and CapSure Macro LCM ... of populations of pure cells from tissue ... Microdissection., Ensure the Integrity of Microdissected ... CapSure LCM Caps have a patented transfer ...
... new MyiQ real-time PCR detection system offers ... common green fluorescent dyes such as FAM ... directly with the iCycler thermal cycler, offering ... Peltier-effect driven performance. The MyiQ real-time PCR ...
Opticon continuous fluorescence detector; includes optical base, analysis software, computer and monitor (this is an accessory for the DNA Engine thermal cyclers which must be ordered seperately)...
Biology Products: