Navigation Links
NRG1 isoforms could be an effective therapeutic candidate to promote peripheral nerve regeneration
Date:7/25/2014

Neuregulin 1 (NRG1) is a pleiotropic factor characterized by the existence of numerous isoforms arising from alternative splicing of exons that confer to the protein deeply different characteristics. NRG1 plays an important role for both the myelination occurring during development and the different phases occurring after injury in the peripheral nerve: axon degeneration, axon regrowth, remyelination and target reinnervation

Researchers at the University of Western Australia have discovered that the soluble NRG1 upregulation observed in Schwann cells immediately after nerve injury suggests that denervated Schwann cells require autocrine stimulation with soluble NRG1 for survival and that the peripheral nerve regeneration impairment observed in animals lacking Schwann cell derived soluble NRG1 is the indirect consequence of problems occurring during the early phases of axon degeneration and axon regrowth, not during the following phases of remyelination and target reinnervation. These observations suggest that soluble NRG1 plays a role during the early phases following nerve injury corresponding to axon degeneration and regrowth, while transmembrane NRG1 plays a role during later phases corresponding to the remyelination process. Therefore, soluble NRG1, already used in human trials for heart failure treatment, could be an effective therapeutic candidate to promote nerve regeneration. The Perspective article is released in Neural Regeneration Research (Vol9, No. 12, 2014)


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert

Page: 1

Related biology news :

1. Could age of first period influence development of diseases in older women?
2. Spinach could lead to alternative energy more powerful than Popeye
3. Danish DNA could be key to happiness
4. Gene discovery could lead to better soybean varieties for Northern United States
5. UEA research reveals how cannabis compound could slow tumour growth
6. Feedback control could be key to robust conservation management
7. Scripps Florida scientists uncover new compounds that could affect circadian rhythm
8. Nanojuice could improve how doctors examine the gut
9. Could boosting brain cells appetites fight disease? New research shows promise
10. Noninvasive advanced image analysis could lead to better patient care
11. Bioelectronics could lead to a new class of medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2016)... , June 15, 2016 ... market report titled "Gesture Recognition Market by Application Market - Global ... 2016 - 2024". According to the report, the  global ... billion in 2015 and is estimated to grow ... 48.56 billion by 2024.  Increasing application ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. and ... business relationship that includes integrating Syngrafii,s patented LongPen™ ... project. This collaboration will result in greater convenience ... credit union, while maintaining existing document workflow and ... ...
(Date:6/2/2016)... The Weather Company , an IBM Business (NYSE: IBM ... which consumers will be able to interact with IBM Watson ... or text and receive relevant information about the product or ... long sought an advertising solution that can create a one-to-one ... valuable; and can scale across millions of interactions and touchpoints. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016  Liquid Biotech USA ... a Sponsored Research Agreement with The University of ... from cancer patients.  The funding will be used ... with clinical outcomes in cancer patients undergoing a ... be employed to support the design of a ...
(Date:6/24/2016)... 2016 Epic Sciences unveiled a liquid ... to PARP inhibitors by targeting homologous recombination deficiency ... new test has already been incorporated into numerous ... types. Over 230 clinical trials are ... including PARP, ATM, ATR, DNA-PK and WEE-1. Drugs ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, ... second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical ... eBook by providing practical tips, tools, and strategies for clinical researchers. , “The ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
Breaking Biology Technology: