Navigation Links
NRG1 isoforms could be an effective therapeutic candidate to promote peripheral nerve regeneration
Date:7/25/2014

Neuregulin 1 (NRG1) is a pleiotropic factor characterized by the existence of numerous isoforms arising from alternative splicing of exons that confer to the protein deeply different characteristics. NRG1 plays an important role for both the myelination occurring during development and the different phases occurring after injury in the peripheral nerve: axon degeneration, axon regrowth, remyelination and target reinnervation

Researchers at the University of Western Australia have discovered that the soluble NRG1 upregulation observed in Schwann cells immediately after nerve injury suggests that denervated Schwann cells require autocrine stimulation with soluble NRG1 for survival and that the peripheral nerve regeneration impairment observed in animals lacking Schwann cell derived soluble NRG1 is the indirect consequence of problems occurring during the early phases of axon degeneration and axon regrowth, not during the following phases of remyelination and target reinnervation. These observations suggest that soluble NRG1 plays a role during the early phases following nerve injury corresponding to axon degeneration and regrowth, while transmembrane NRG1 plays a role during later phases corresponding to the remyelination process. Therefore, soluble NRG1, already used in human trials for heart failure treatment, could be an effective therapeutic candidate to promote nerve regeneration. The Perspective article is released in Neural Regeneration Research (Vol9, No. 12, 2014)


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert

Page: 1

Related biology news :

1. Could age of first period influence development of diseases in older women?
2. Spinach could lead to alternative energy more powerful than Popeye
3. Danish DNA could be key to happiness
4. Gene discovery could lead to better soybean varieties for Northern United States
5. UEA research reveals how cannabis compound could slow tumour growth
6. Feedback control could be key to robust conservation management
7. Scripps Florida scientists uncover new compounds that could affect circadian rhythm
8. Nanojuice could improve how doctors examine the gut
9. Could boosting brain cells appetites fight disease? New research shows promise
10. Noninvasive advanced image analysis could lead to better patient care
11. Bioelectronics could lead to a new class of medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2016)... MIAMI , Dec. 16, 2016   ... intuitive Identity management products and solutions and a ... announced today that it is offering seamless, integrated ... Edam security entrance products. The solutions provide IdentyTech,s ... to secure their facilities from crime and theft. ...
(Date:12/15/2016)... VANCOUVER, Canada and BADEN-BADEN, Germany ... Solutions, a leading global financial services provider, today announced an ... in passive behavioural biometrics, to join forces. The partnership will ... fraud mitigation strategies in compliance with local data protection regulation. ... In ...
(Date:12/15/2016)... , Dec. 15, 2016 ... driving experience, health wellness and wellbeing (HWW), ... one in three new passenger vehicles begin ... recognition, gesture recognition, heart beat monitoring, brain ... monitoring, facial monitoring, and pulse detection. These ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... ... January 24, 2017 , ... ZeptoMetrix ... falciparum culture panels with standard concentrations of histidine rich protein 2 (HRP2). ... range of concentrations from six different malaria strains, are intended for use by ...
(Date:1/24/2017)... ... January 23, 2017 , ... Oklahoma City based Sigma ... client for the firm’s PERFEQTA software and legacy product QC Manager 2.0. , ... dynamic team at CJBC and thrilled that they have decided to implement PERFEQTA and ...
(Date:1/24/2017)... Jan. 23, 2017 /PRNewswire/ - BioAmber Inc. (NYSE: ... an underwriting agreement with Rodman & Renshaw, a unit ... sole book running manager and representative of several underwriters, under ... firm commitment basis a minimum of 2,105,264 shares of ... purchase a minimum of 1,052,632 shares of common stock ...
(Date:1/23/2017)... Atlas Genetics Ltd., the ultra-rapid Point-Of-Care (POC) molecular ... raising $35 million from a syndicate including all Series C ... ... Genetics io® system has been completed with the successful CE ... 2016.  This new Series D equity issue will finance the ...
Breaking Biology Technology: