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NREL finds a new cellulose digestion mechanism by a fast-eating enzyme
Date:1/7/2014

y catalytic domains working in concert most likely makes it such a good cellulose degrader."

Most commercial operations use enzyme cocktails, a combination of 15 to 20 different enzymes, to turn plant material into the sugars that are valuable to the biofuels industry. In most such cocktails, one type of enzyme, Cel7A, does the largest amount of work.

When researchers compared CelA to Cel7A, they discovered that at its optimal temperature of 50 degrees Celsius (122 degrees F), Cel7A achieves only 50% of the performance of CelA when converting Avicel.

CelA was discovered 15 years ago, but until this recent work, all that was known about this complex protein was its general architecture and that it had the ability to degrade cellulose.

This organism, initially grown on biomass by scientists from the University of Georgia, was used to produce extracellular enzymes (enzymes that function outside of the cell). Those extracellular enzymes later were purified and characterized at NREL using techniques including performance assays, advanced imaging, X-ray crystallography, and modeling on supercomputers.

NREL scientists found that CelA is not only very active on cellulose, but also attacks xylose. That could mean that levels of enzymes that specialize in removing xylose in commercial cocktails could be lowered, translating to lower costs.

If an enzyme can produce sugars more efficiently, it means lower cost for the enzyme cocktail, which is a major cost driver in the process of converting biomass into fuel.

The findings have important implications for industry, but also were fascinating for the scientists. "We are learning a lot about the evolution of these cellulases, how they can thrive in extreme environments, and how they operate on biomass," NREL scientist and the paper's lead author, Roman Brunecky, said.

"This discovery could reshape the landscape of commercial cellulase cocktail design," said Pau
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Contact: David Glickson
david.glickson@nrel.gov
303-275-4097
DOE/National Renewable Energy Laboratory
Source:Eurekalert

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