Navigation Links
NPL models the extracellular matrix
Date:12/20/2011

Scientists at the National Physical Laboratory (NPL) have created a functional model of the native extracellular matrix that provides structural support to cells to aid growth and proliferation. The model could lead to advances in regenerative medicine.

The extracellular matrix (ECM) provides the physical and chemical conditions that enable the development of all biological tissues. It is a complex nano-to-microscale structure made up of protein fibres and serves as a dynamic substrate that supports tissue repair and regeneration.

Man-made structures designed to mimic and replace the native matrix in damaged or diseased tissues are highly sought after to advance our understanding of tissue organisation and to make regenerative medicine a reality.

Self-assembling peptide fibres that have similar properties to those of the native matrices are of particular interest. However, these near-crystalline nanostructures fail to arrange themselves into interconnected meshes at the microscopic scale, which is critical for bringing cells together and supporting tissue development.

To solve this problem, a research team at NPL designed a small protein consisting of two complementary domains (structural units) that promote the formation of highly branched networks of fibres that span microscopic dimensions. The team showed that the created matrix is very efficient in supporting cell attachment, growth and proliferation.

Max Ryadnov, the lead researcher at NPL, said: "The extracellular matrix is a cellular "scaffolding", which provides necessary signalling environment for cell growth and development into tissues and can help to heal wounds and other damaged tissues. Therefore, extracellular mimetics such as one developed by NPL could be useful for the progress of regenerative medicine."


'/>"/>
Contact: David Lewis
david@proofcommunication.com
084-568-01865
National Physical Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. People matter in climate change models
2. OpenSim open-source software from Stanford accurately models human motion
3. Scale models
4. CWRU receives $2.1 million NIH grant to expand cystic fibrosis research models
5. Models show Coho salmon at risk in US urbanizing watersheds
6. Zebrafish models identify high-risk genetic features in leukemia patients
7. New models may reduce seabird bycatch
8. Nicotine does not promote lung cancer growth in mouse models
9. MIT systems biologists use computer models to predict animal cell behavior
10. Research brings habitat models into the future
11. New discoveries improve climate models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014  Automation is fundamentally transforming the travel ... at international borders. Over the past decade, ePassports, ... veteran travelers to self process through border control ... at an increasing number of airports, seaports, and ... According to Maxine Most , Principal at ...
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the ... 2015-2019" report to their offering. ... is the adoption of multimodal biometric systems. Multimodal ... an individual for verification and identification purposes. This ...
(Date:12/10/2014)... Dec. 8, 2014 You,ve been here before: you ... can,t remember your password, site key or the answer to ... first grade teacher? Today, Hoyos Labs ... app that will finally put an end to the frustration ... TM . 1U leverages a user,s smartphone to acquire ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... professor of medicine at National Jewish Health, has ... lipids and related compounds that can inhibit inflammation ... by influenza and respiratory syncytial virus (RSV). Over ... several scientific papers describing a naturally occurring lipid ...
... bunch of inanimate chemical compounds, the nucleic and amino acids ... have put on quite a soap opera for biologists since ... A new study, a highlight in the March issue of ... In TV listings the series would be described this ...
... considered to be the principle vectors of West Nile virus ... summer. In addition, these mosquitoes may also serve as overwintering ... mosquito to egg, then larva, and then adult. To ... in mosquitoes in the field and in the lab, and ...
Cached Biology News:Does the villainous 'selfish' gene undermine genome's police? 2Does the villainous 'selfish' gene undermine genome's police? 3West Nile virus passes from female to eggs, but less so from larvae to adults 2
(Date:12/22/2014)... ITRA Global, one of the largest organizations dedicated ... has further expanded its global reach with the affiliation ... Australia, reports Mylinda Vick, CCIM, Chairman of the ITRA ... ACORPP (Australian Corporate Property and Projects) , is a ... to a wide range of clients in the private ...
(Date:12/19/2014)... MA (PRWEB) December 19, 2014 Charm ... MRLAFMQ test for the Detection of Aflatoxin M1 in ... to receive independent third party validation. The peer reviewed ... Unit of the Institute for Agricultural and Fisheries Research ... Group. , Aflatoxin B1, the most toxic aflatoxin ...
(Date:12/19/2014)... , Dec. 19, 2014  Roche (SIX: RO, ROG; ... Technologies, Inc. (Bina), a privately held company based ... USA. Bina provides a big data platform for ... (NGS) data. Bina,s proprietary on-market Genomic Management Solution, ... researchers to perform fast and scalable analyses to ...
(Date:12/19/2014)... 2014 Research and Markets ( ... "Technology Innovations in Smart Fabrics (Technical Insights)" ... http://photos.prnewswire.com/prnh/20130307/600769 The Research ... a detailed assessment on technological advancements and market ... 1. The Smart Fabrics market is ...
Breaking Biology Technology:ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Technology Innovations in Smart Fabrics (Technical Insights) 2
... WOODLANDS, Texas, June 17 Berlin Heart Inc. today,announced ... by the FDA,to support the ongoing Investigational Device Exemption ... Dr. Christopher Almond of,the Children,s Hospital of Boston, and ... Inc. will serve as Co-Principal,Investigators for the grant project ...
... N.C., June 17 /PRNewswire/ -- Campbell Alliance, the ... industry, today announced that it has launched a new practice ... at Campbell Alliance, the Medical Affairs practice enables the firm ... , , "Our firm has done work ...
... June 17 /PRNewswire-Asia-FirstCall/ -- China-Biotics, Inc.,(Nasdaq: ... firm,specializing in the manufacture, research, development, marketing and,distribution ... the Russell,3000(R) Index and Russell Global(R) Index when ... global equity indices on June,26, 2009, according to ...
Cached Biology Technology:Berlin Heart Inc. Receives FDA Orphan Product Development Grant 2Campbell Alliance Launches New Practice Area Focused on Medical Affairs 2China-Biotics, Inc. to Join Russell 3000 Index 2China-Biotics, Inc. to Join Russell 3000 Index 3
... is ideal for high-fidelity amplification of ... as cloning and mutagenesis. High ... enzyme preparation containing recombinant DNA polymerase ... Site5' exonuclease) activity. Platinum Anti-Pfx ...
... The EC105 power supply is a highly compact, ... A single adjustment knob and one hi-lo range ... 10 volt increments from 20 to 250 volts. ... from indicating output voltage to output current. For ...
... precision beveling of micropipette tips ... unique abrasive plate drive system ... control of the beveling process. ... rapidly and produces consistent tip ...
...
Biology Products: