NIST trumps the clumps: Making biologic d...(tical applications. According to researc...)

Date:7/23/2008

tical applications. According to researcher Leonard Pease, ES-DMA is tricky to get right, but the NIST team was able to define the conditions needed to electrospray proteins and protein aggregates reliably and repeatedly. NIST scientists favor ES-DMA for its ability to quickly resolve particle sizes differing by as little as 0.2 nanometers, to provide a direct measure of particle size distributions, and to accept bioreactor samples with significantly reduced preparation requirements.

In addition to sizing proteins, Pease said the technique could also be used to accurately size many different types of particles used in medicine, such as the viruses used in the human papillomavirus (HPV) vaccine and gene therapy. The adaptation of this technology is just one of many excellent examples of how NIST seeks out and works with U.S. industry, says Willie E. May, director of the NIST Chemical Science and Technology Laboratory.

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Contact: Mark Esser mark.esser@nist.gov 301-975-8735 National Institute of Standards and Technology (NIST) Source:Eurekalert

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