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NIST technique controls sizes of nanoparticle clusters for EHS studies
Date:2/2/2011

d with horse blood in an attempt to study the impact of clumping size on red blood cell toxicity. The presence of hemoglobin, the iron-based molecule in red blood cells that carries oxygen, would tell researchers if the cells had been lysed (broken open) by silver ions released into the solution from the clusters. In turn, measuring the amount of hemoglobin in solution for each cluster size would define the level of toxicitypossibly related to the level of silver ion releasefor that specific average size.

What the researchers found was that red blood cell destruction decreased as cluster size increased. They hypothesize that large nanoparticle clusters dissolve more slowly than small ones, and therefore, release fewer silver ions into solution.

In the future, the NIST team plans to further characterize the different cluster sizes achievable through their production method, and then use those clusters to study the impact on cytotoxicity of coatings (such as polymers) applied to the nanoparticles.


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Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

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