Navigation Links
NIST study suggests carbon nanotubes may protect DNA from oxidation
Date:11/15/2012

Researchers at the National Institute of Standards and Technology (NIST) have provided evidence in the laboratory that single-wall carbon nanotubes (SWCNTs) may help protect DNA molecules from damage by oxidation. In nature, oxidation is a common chemical process in which a reactive chemical removes electrons from DNA and may increase the chance for mutations in cells. More studies are needed to see if the in vitro protective effect of nanotubes reported in the laboratory also occurs in vivo, that is, within a living organism.

"Our findings don't tell us whether carbon nanotubes are good or bad for people and the environment," says Elijah Petersen, one of the authors of the study. "However, the results do help us better understand the mechanisms by which nanotubes might interact with biomolecules."

Single-wall carbon nanotubestiny hollow rods that are one-atom-thick sheets of graphene rolled into cylinders 10,000 times smaller in diameter than a human hairare prized for their extraordinary optical, mechanical, thermal and electronic properties. They are being used to produce lightweight and extremely strong materials, enhance the capabilities of devices such as sensors, and provide a novel means of delivering drugs with great specificity. However, as carbon nanotubes become increasingly incorporated into consumer and medical products, the public concern about their potential environmental, health and safety (EHS) risks has grown. Scientifically determining the level of risk associated with the carbon nanotubes has been challenging, with different studies showing conflicting results on cellular toxicity. One of the components lacking in these studies is an understanding of what physically happens at the molecular level.

In a recent paper,* NIST researchers investigated the impact of ultrasonication on a solution of DNA fragments known as oligomers in the presence and absence of carbon nanotubes. Ultrasonication is a standard laboratory technique that uses high-frequency sound waves to mix solutions, break open cells or process slurries. The process can break water molecules into highly reactive agents such as hydroxyl radicals and hydrogen peroxide that are similar to the oxidative chemicals that commonly threaten mammalian cell DNA, although the experimental levels from sonication are much greater than those found naturally within cells. "In our experiment, we were looking to see if the nanotubes enhanced or deterred oxidative damage to DNA," Petersen says.

Contrary to the expectation that carbon nanotubes will damage biomolecules they contact, the researchers found that overall levels of accumulated DNA damage were significantly reduced in the solutions with nanotubes present. "This suggests that the nanotubes may provide a protective effect against oxidative damage to DNA," Petersen says.

A possible explanation for the surprising result, Petersen says, is that the carbon nanotubes may act as scavengers, binding up the oxidative species in solution and preventing them from interacting with DNA. "We also saw a decrease in DNA damage when we did ultrasonication in the presence of dimethyl sulfoxide (DMSO), a chemical compound known to be a hydroxyl radical scavenger," Petersen says.

Petersen says that a third experiment where ultrasonication was performed in the presence of DMSO and SWCNTs at the same time produced an additive effect, reducing the DNA damage levels more significantly than either treatment alone.


'/>"/>

Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Related biology news :

1. New study finds milk-drinking kids reap physical benefits later in life
2. New brain gene gives us edge over apes, study suggests
3. Study investigates headshaking in horses
4. New study reveals more inspiring reasons to serve veggies at dinner
5. Nature study reveals loss of essential blood cell gene leads to anemia
6. Study sheds light on genetic clock in embryonic cells
7. Study offers new tool for incorporating water impacts into policy decisions
8. Study provides recipe for supercharging atoms with X-ray laser
9. Study documents eating of soil, raw starch in Madagascar
10. UH Case Medical Center leads international study
11. Researchers to study impacts of pollutant nitrogen on plant species diversity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIST study suggests carbon nanotubes may protect DNA from oxidation
(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. ... company, announces the filing of its 2016 Annual Report on Form ... Exchange Commission. ... Form 10-K is available in the Investor Relations section of the ... on the SEC,s website at http://www.sec.gov . 2016 ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... May 23, 2017 As Ebola resurfaces in the ... deaths and 20 suspected cases now reported, a new analysis ... database, showed a correlation between the 2014 and 2017 outbreaks ... rose sharply in 2012-13, which preceded the 2014 outbreak. An ... Ebola gene Replikin counts in 2014-15, which again precedes the ...
(Date:5/23/2017)... Yorba Linda, Ca (PRWEB) , ... ... ... stem cells (PSCs) offer an unlimited source of human cardiovascular cells for ... efficient cardiac-directed differentiation methods makes it possible to generate large numbers of ...
(Date:5/23/2017)... ... May 22, 2017 , ... ... in San Diego, California, this August will feature high-level speakers on quantum ... vehicles. , SPIE Optics and Photonics, the largest multidisciplinary optical sciences meeting in ...
(Date:5/23/2017)... Philadelphia, PA. (PRWEB) , ... May 23, 2017 ... ... Clinical Works as Vice President of Clinical Operations. She brings years ... Pharmaceuticals, and Yaupon Therapeutics. From her professional foundation as a licensed occupational therapist, ...
Breaking Biology Technology: