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NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
Date:4/18/2012

Researchers at the National Institute of Standards and Technology (NIST) and the University of Massachusetts Amherst (UMass) have provided the first evidence that engineered nanoparticles are able to accumulate within plants and damage their DNA. In a recent paper,* the team led by NIST chemist Bryant C. Nelson showed that under laboratory conditions, cupric oxide nanoparticles have the capacity to enter plant root cells and generate many mutagenic DNA base lesions.

The team tested the man-made, ultrafine particles between 1 and 100 nanometers in size on a human food crop, the radish, and two species of common groundcovers used by grazing animals, perennial and annual ryegrass. This research is part of NIST's work to help characterize the potential environmental, health and safety (EHS) risks of nanomaterials, and develop methods for identifying and measuring them.

Cupric oxide (also known as copper (II) oxide or CuO) is a compound that has been used for many years as a pigment for coloring glass and ceramics, as a polish for optics, and as a catalyst in the manufacture of rayon. Cupric oxide also is a strong conductor of electric current, a property enhanced at the nanoscale level, which makes the nanoparticle form useful to semiconductor manufacturers.

Because cupric oxide is an oxidizing agenta reactive chemical that removes electrons from other compoundsit may pose a risk. Oxidation caused by metal oxides has been shown to induce DNA damage in certain organisms. What Nelson and his colleagues wanted to learn was whether nanosizing cupric oxide made the generation and accumulation of DNA lesions more or less likely in plants. If the former, the researchers also wanted to find out if nanosizing had any substantial effects on plant growth and health.

To obtain the answers, the NIST/UMass researchers first exposed radishes and the two ryegrasses to both cupric oxide nanoparticles and larger sized cupric oxide particles (b
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Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

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NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
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