Navigation Links
NIST/UMass study finds evidence nanoparticles may increase plant DNA damage

Researchers at the National Institute of Standards and Technology (NIST) and the University of Massachusetts Amherst (UMass) have provided the first evidence that engineered nanoparticles are able to accumulate within plants and damage their DNA. In a recent paper,* the team led by NIST chemist Bryant C. Nelson showed that under laboratory conditions, cupric oxide nanoparticles have the capacity to enter plant root cells and generate many mutagenic DNA base lesions.

The team tested the man-made, ultrafine particles between 1 and 100 nanometers in size on a human food crop, the radish, and two species of common groundcovers used by grazing animals, perennial and annual ryegrass. This research is part of NIST's work to help characterize the potential environmental, health and safety (EHS) risks of nanomaterials, and develop methods for identifying and measuring them.

Cupric oxide (also known as copper (II) oxide or CuO) is a compound that has been used for many years as a pigment for coloring glass and ceramics, as a polish for optics, and as a catalyst in the manufacture of rayon. Cupric oxide also is a strong conductor of electric current, a property enhanced at the nanoscale level, which makes the nanoparticle form useful to semiconductor manufacturers.

Because cupric oxide is an oxidizing agenta reactive chemical that removes electrons from other compoundsit may pose a risk. Oxidation caused by metal oxides has been shown to induce DNA damage in certain organisms. What Nelson and his colleagues wanted to learn was whether nanosizing cupric oxide made the generation and accumulation of DNA lesions more or less likely in plants. If the former, the researchers also wanted to find out if nanosizing had any substantial effects on plant growth and health.

To obtain the answers, the NIST/UMass researchers first exposed radishes and the two ryegrasses to both cupric oxide nanoparticles and larger sized cupric oxide particles (bigger than 100 nanometers) as well as to simple copper ions. They then used a pair of highly sensitive spectrographic techniques** to evaluate the formation and accumulation of DNA base lesions and to determine if and how much copper was taken up by the plants.

For the radishes, twice as many lesions were induced in plants exposed to nanoparticles as were in those exposed to the larger particles. Additionally, the cellular uptake of copper from the nanoparticles was significantly greater than the uptake of copper from the larger particles. The DNA damage profiles for the ryegrasses differed from the radish profiles, indicating that nanoparticle-induced DNA damage is dependent on the plant species and on the nanoparticle concentration.

Finally, the researchers showed that cupric oxide nanoparticles had a significant effect on growth, stunting the development of both roots and shoots in all three plant species tested. The nanoparticle concentrations used in this study were higher than those likely to be encountered by plants under a typical soil exposure scenario.

"To our knowledge, this is first evidence that there could be a 'nano-based effect' for cupric oxide in the environment where size plays a role in the increased generation and accumulation of numerous mutagenic DNA lesions in plants," Nelson says.

Next up for Nelson and his colleagues is a similar study looking at the impact of titanium dioxide nanoparticlessuch as those used in many sunscreenson rice plants.


Contact: Michael E. Newman
National Institute of Standards and Technology (NIST)

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
Related Image:
NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
(Date:11/18/2015)... -- As new scientific discoveries deepen our understanding of how ... face challenges in better using that knowledge to guide ... more children continue to survive pediatric cancer, that counseling ... John M. Maris, M.D ., a pediatric ... . --> John M. Maris, M.D ...
(Date:11/17/2015)... PARIS , November 17, 2015 ... November 2015.   --> Paris from ... --> DERMALOG, the biometrics innovation leader, has invented the ... and fingerprints on the same scanning surface. Until now two ... fingerprints. Now one scanner can capture both on the same ...
(Date:11/17/2015)... LIVERMORE, Calif. , Nov. 17, 2015  Vigilant ... has joined its Board of Directors. ... Vigilant,s Board after recently retiring from the partnership at ... owning 107 companies with over $140 Billion in revenue.  ... performance improvement across all the TPG companies, from 1997 ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... SHPG ) announced today that Jeff Poulton , Chief ... Annual Healthcare Conference in New York City , ... p.m. GMT). --> SHPG ) announced today that ... Jaffray 27 th Annual Healthcare Conference in New ... 8:30 a.m. EST (1:30 p.m. GMT). --> Shire plc ...
(Date:11/24/2015)... ... 2015 , ... In harsh industrial processes, the safety of ... can represent a weak spot where leaking process media is a possible hazard. ... , which are designed to tolerate extreme process conditions. They combine rugged design ...
(Date:11/24/2015)... CHARLOTTESVILLE, Va. , Nov. 24, 2015 /PRNewswire/ ... company focused on discovering drugs for metabolic disorders, ... Watkins to its Board of Directors (BOD). ... executive officer of Human Genome Sciences (HGS), and ... Industry Organization. Jim Powers , Chairman ...
(Date:11/23/2015)... 24, 2015 Women with a certain type of ... a higher risk of lung cancer than men with similar ... at the annual meeting of the Radiological Society of ... --> --> Lung nodules are small masses ... or subsolid based on their appearance on CT. Solid nodules ...
Breaking Biology Technology: