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NIH to fund collaborations with industry to identify new uses for existing compounds
Date:6/18/2013

ify new uses for compounds that have undergone significant research and development by industry, including safety testing in humans. The Center crowdsourced the industry compounds to academic researchers nationwide to gain ideas for new therapeutic uses with the ultimate goal of developing new treatments for patients.

The program also tested newly created template agreements, which enabled negotiations to be completed in fewer than 11 weeks, versus a typical timeline of a year or more.

"Public-private collaborations are crucial for successful translation; no one organization can succeed alone," said NCATS Director Christopher P. Austin, M.D. "This initiative has created a marketplace to connect academic researchers with potential new drugs, as well as template agreements that streamline the process by limiting the amount of negotiation required before a project can begin."

Each award recipient will test a selected compound for its effectiveness against a previously unexplored disease or condition. The eight disease areas represented are alcohol dependence, Alzheimer's disease, calcific aortic valve stenosis (a condition in which the heart valve hardens and makes it difficult to pump blood out of the heart), nicotine dependence, peripheral artery disease, schizophrenia and two rare diseases: Duchenne muscular dystrophy and the progressive lung disease lymphangioleiomyomatosis. For more details about each project, please visit http://www.ncats.nih.gov/therapeutics-projects.html.

The projects, award recipient principal investigators and industry partners are:

The efficacy and safety of a selective estrogen receptor beta agonist (LY500307)

Academic Partner: Alan Breier, M.D., Indiana University, Indianapolis

Industry Partner: Eli Lilly and Company

Fyn inhibition by AZD0530 for Alzheimer's disease

Academic
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Contact: NCATS Office of Communications
ncatsinfo@mail.nih.gov
301-435-0888
NIH/National Center for Advancing Translational Sciences (NCATS)
Source:Eurekalert

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