Navigation Links
NIH supporting Arizona State University research to help in fight against kidney disease
Date:6/8/2012

Research led by an Arizona State University biomedical engineer and physicist to find more effective ways of detecting the onset of kidney disease is getting support from the National Institutes of Health.

The NIH has awarded $400,000 to Kevin Bennett, an assistant professor of the School of Biological and Health Systems Engineering, one of ASU's Ira A. Fulton Schools of Engineering.

The grant will support his team's research focusing on a common form of kidney disease called nephritis.

"A significant portion of the diabetic population and others will develop kidney disease. The earlier we can detect it, the more likely it is that we can effectively treat it," Bennett says.

The current method of identifying kidney disease is to perform a biopsy, which can be painful for patients and prone to errors. Bennett is working on a method using magnetic resonance imaging (MRI) technology that involves magnetic particles.

His team has engineered magnetic nanoparticles that stick to the glomerulus, a part of the kidney that is attached to the nephron. The nephron is a part of the kidney that regulates the level of water and soluble substances in the blood.

By doing an MRI scan on a kidney onto which magnetic nanoparticles have been bound, it creates a visible distortion in the image that enables researchers to extract information about the nephron.

The distortions in such images enable nephrons to be accurately located, their size can be determined and changes in their behavior can be revealed. "If we can detect changes in nephron function early, patients can be treated earlier and with better results," Bennett says.

Another application of the research is in examination of the relationship between the number of nephrons and the risk of cardiovascular and kidney diseases in humans, which is currently done by taking sections of body tissue.

Researchers are also looking at how nanoparticle uptake in the kidneys is affected by diabetes and the strain nanoparticle uptake puts on the kidneys.

"We are doing this with noninvasive imaging. We are developing ways to detect all of this without having to do biopsies or collect body tissue," Bennett explains.

Bennett's team includes: professor Teresa Wu, an industrial engineer and an associate professor in the School of Computing, Informatics, and Decision Systems Engineering in the Ira A. Fulton Schools of Engineering; Min Zhang, a doctoral student working under Wu; professor John Bertam, head of Anatomy and Developmental Biology at Monash University in Australia; and Scott Beeman, a biomedical engineering doctoral student working in Bennett's laboratory.

Beeman has taken a lead role in the kidney research project and recently presented a progress report at a meeting of the International Society for Magnetic Resonance Medicine in Melbourne, Australia.

"It's rare that a Ph.D. student can push a whole field of research forward, but that's what Scott has done," Bennett says.

The team is already in the preclinical stage of research. "We are moving the technique to clinical trials, and we have already developed better nanoparticles and more sensitive ways to detect them."

The next step will be working with human donor kidneys.


'/>"/>
Contact: Joe Kullman
joe.kullman@asu.edu
480-965-8122
Arizona State University
Source:Eurekalert

Related biology news :

1. UC Davis scientists find new role for P53 genetic mutation -- initiation of prostate cancer
2. SF State biology department receives $1.5 million to support science teaching
3. Could cap and trade for water solve problems facing the United States largest rivers?
4. Scientists identify prostate cancer stem cells among low-PSA cells
5. Beehive extract shows potential as prostate cancer treatment
6. Experiments may understate plant responses to climate
7. Syracuse University study finds autumn advantage for invasive plants in eastern United States
8. New diagnostic tool determines aggressiveness of prostate cancer
9. Ohio state hosts national energy conference
10. Study shows botanical formula fights prostate cancer
11. NRC authors brief federal agencies on the state of polar regions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... , UAE, April 20, 2016 ... be implemented as a compact web-based "all-in-one" system solution ... the biometric fingerprint reader or the door interface with ... of modern access control systems. The minimal dimensions of ... ID readers into the building installations offer considerable freedom ...
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... June 24, 2016  Regular discussions on a range of ... between the two entities said Poloz. Speaking at ... Ottawa , he pointed to the country,s inflation target, ... government. "In certain ... institutions have common economic goals, why not sit down and ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute approval ... of microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the ... at the Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application ... team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our ...
Breaking Biology Technology: