Navigation Links
NIH study reveals gene critical to the early development of cilia
Date:7/1/2014

tein needed for cilia growth, but its precise functions have been unclear.

Researchers developed a mouse lacking Cc2d2a to investigate the gene.

When they looked at the tissues of the mutant mice in very early stages of development, researchers found very few to no cilia, suggesting the gene plays a critical role at an early time. Looking closely at where the cilia should exist, the researchers saw that the supporting structures needed for cilia to grow were either completely missing or abnormal. In other experiments, the researchers found that the absence of Cc2d2a affected the activity of other genes and proteins involved in mouse nervous system development, including the key signaling protein, sonic hedgehog.

"This gene appears to play a key role in building structural support for the development of the cilia. Without this support, cilia are prevented from anchoring in the cell," said Dr. Swaroop. "It's like trying to build a house without a foundation. It's a big structural defect."

Studying the function and structure of cilia has become an active field of research that touches on many different organs and biological systems. More than 50 genes, including Cc2d2a have been discovered that, when defective, can lead to abnormal cilia development and ciliopathy in humans. By continuing to study how these genes work and interact, Dr. Swaroop said he hopes to gain further insight into not just how defects in genes related to cilia development in the retina cause vision problems, but the wider impact of these defects across body system and organs.


'/>"/>

Contact: Jean Horrigan
neinews@nei.nih.gov
301-496-5248
NIH/National Institute on Deafness and Other Communication Disorders
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... JOSE, Calif. , June 17, 2015 /PRNewswire/ ... in human interface solutions, today announced that Xiaomi, ... adopted the Synaptics ® ClearPad ® ... of display driver integrated circuits (DDICs) for its ... Pro. By leveraging ClearPad for full in-cell display ...
(Date:6/16/2015)... 2015 Fingerprint Cards (FPC) raises the ... will amount to at least 340 MSEK to that it ... increase in market growth and orders received the revenue guidance ... revenue for 2015 will exceed 1,500 MSEK to an updated ... MSEK. Due to receipt of orders of touch ...
(Date:6/11/2015)... Va. , June 11, 2015 ... technology, announced today that its IdentityX Mobile Authentication ... (Fast IDentity Online) Alliance is an industry consortium ... open standards for simpler, stronger authentication.  In order ... must pass a rigorous series of tests that ...
Breaking Biology News(10 mins):Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2
... the UK have presented evidence that vigorous physical activity ... results were presented at the World Congress on Osteoporosis ... six-year olds participated in the study. Using advanced scanning ... structure of the femoral neck (hip) and thigh bone. ...
... Hinxton, 10 May 2010 The European Nucleotide Archive ... to become Europe,s primary access point to globally comprehensive ... available from the European Bioinformatics Institute (EMBL-EBI), a part ... DNA sequencing has led to previously unimaginable amounts of ...
... sources of renewable energy, but which ones should industry ... new study involving researchers from North Carolina State University ... burned. Their data and new computer models pave the ... maximize energy efficiency while minimizing environmental and human health ...
Cached Biology News:Enabling easy access to DNA sequence information 2Study paves way for new biofuels models, technologies 2
(Date:6/29/2015)... 29, 2015 According to a new ... by Application (Diagnostics, Therapeutics, R&D), by Technology (SELEX, Other Technologies), ... CRO) - Global Forecast to 2020", published by MarketsandMarkets, the ... 2020 from $107.56 Million in 2015, at a CAGR of ... and 67 F igures spread through 125 ...
(Date:6/29/2015)... Elsevier , a world-leading ... services, today announced the highlights of its journal Impact ... Citation Reports® (JCR) published by Thomson Reuters, Elsevier saw ... to 2014, ahead of the aggregate across other journals. ... 62 subject categories, up from 61 in 2013. ...
(Date:6/26/2015)... Lawrence, MA (PRWEB) , ... June 26, 2015 ... ... the U.S. Department of Agriculture (USDA), Grain Inspection, Packers and Stockyards Administration (GIPSA) ... referred to as vomitoxin in feed and grains utilizing Charm’s ROSA DONQ-FAST5 Test. ...
(Date:6/26/2015)... June 23, 2015 ... addition of the "Global Cancer Biosimilars Market ... Market introduction of cancer biosimilar is required ... potential. Chemotherapeutic drugs have dominated the cancer segment ... been introduced in past few years. They are ...
Breaking Biology Technology:Aptamers Market Worth $244.93 Million by 2020 2Aptamers Market Worth $244.93 Million by 2020 3Aptamers Market Worth $244.93 Million by 2020 4Elsevier Announces 2014 Citation Impact Highlights 2Elsevier Announces 2014 Citation Impact Highlights 3USDA-GIPSA (FGIS) Awards 5 Year Contract for Vomitoxin Tests to Charm Sciences 2Global Cancer Biosimilars Market Opportunity Outlook 2Global Cancer Biosimilars Market Opportunity Outlook 3
... Calif., Nov. 20 AMDL, Inc. (Amex:,ADL), ... China, through its,wholly owned subsidiary Jade Pharmaceutical ... in the development, manufacture and,marketing of proprietary ... has launched significant new expansion plans to ...
... into an old idea, MIT Institute Professor Mildred ... for controlling temperatures that could lead to substantial ... photovoltaic cells and electronic devices. , Novel ... consumer product: a simple, efficient way of cooling ...
... (Nasdaq: EXEL ) announced today that that it will hold ... a.m. ET /,7:00 a.m. PT to 2:00 p.m. ET / 11:00 ... and may be accessed in the Event Calendar,page under Investors at ... available until 9:00 p.m. PT / 12:00,a.m. ET on January 4, ...
Cached Biology Technology:AMDL Launches New JPGreen Business Strategy 2MIT: Thermoelectric materials are 1 key to energy savings 2MIT: Thermoelectric materials are 1 key to energy savings 3
... Clone/PAD: ZMD.473. Immunogen: Synthetic peptide ... the mouse junctophilin-2. Specificity: Specific ... Mouse (positive controls: mouse skeletal muscle ... Applications: Western blotting Immunohistochemistry(froz) ImmunofluorescenceStorage: ...
TGF-beta 2 MAb (Clone 8607)...
UCP1/2/3 (FL-307)...
ABIN-2 Polyclonal Ab 100 ug rabbit polyclonal antibody. Detects ABIN-2 in human/mouse. Tested in WB....
Biology Products: