Navigation Links
NIH study reveals gene critical to the early development of cilia
Date:7/1/2014

tein needed for cilia growth, but its precise functions have been unclear.

Researchers developed a mouse lacking Cc2d2a to investigate the gene.

When they looked at the tissues of the mutant mice in very early stages of development, researchers found very few to no cilia, suggesting the gene plays a critical role at an early time. Looking closely at where the cilia should exist, the researchers saw that the supporting structures needed for cilia to grow were either completely missing or abnormal. In other experiments, the researchers found that the absence of Cc2d2a affected the activity of other genes and proteins involved in mouse nervous system development, including the key signaling protein, sonic hedgehog.

"This gene appears to play a key role in building structural support for the development of the cilia. Without this support, cilia are prevented from anchoring in the cell," said Dr. Swaroop. "It's like trying to build a house without a foundation. It's a big structural defect."

Studying the function and structure of cilia has become an active field of research that touches on many different organs and biological systems. More than 50 genes, including Cc2d2a have been discovered that, when defective, can lead to abnormal cilia development and ciliopathy in humans. By continuing to study how these genes work and interact, Dr. Swaroop said he hopes to gain further insight into not just how defects in genes related to cilia development in the retina cause vision problems, but the wider impact of these defects across body system and organs.


'/>"/>

Contact: Jean Horrigan
neinews@nei.nih.gov
301-496-5248
NIH/National Institute on Deafness and Other Communication Disorders
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... native animal species for food or commercial food sale, ... in the decline of many species of primates and ... more than half of the species being consumed are ... surveying not only the meat made available for sale ... forest by hunters and brought to villages for consumption, ...
(Date:7/24/2014)... has different effects on different species of fish, ... of Bristol and Exeter which tested fish anti-predator ... a flying seagull predator model when exposed to ... European minnows. , Lead author Dr Irene ... "Noise levels in many aquatic environments have increased ...
(Date:7/24/2014)... a smog-free Los Angeles, where electric cars ply silent ... on heat from beneath the earth, from howling winds ... Stanford study finds that it is technically and economically ... powered by clean, renewable energy. Published in Energy ... inexpensive and reliable energy supply in California that could ...
Breaking Biology News(10 mins):Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4
... UT Southwestern Medical Center scientists have synthesized a peptide ... treating infections, neurodegenerative disorders, and cancer through an ability ... is a fundamental recycling process in which intracellular enzymes ... their individual building blocks, which are then reassembled into ...
... generation destroy malignant breast tumors in a targeted manner: ... receptors for the hormones estrogen or progesterone, or a ... But about one in every six breast tumors has ... particularly aggressive and notoriously difficult to treat. ...
... rising a threat to island nations. As a group ... found out, at the same time, tiny single-cell organisms are ... able to mitigate the consequences of climate change. ... and reefs with their calcareous shells. The study,s results have ...
Cached Biology News:Unique peptide could treat cancers, neurological disorders, and infectious diseases 22 antibodies are better than 1 2Profiting from climate change 2Profiting from climate change 3
(Date:7/25/2014)... bacteria live in each person,s digestive tract. Scientists believe ... stave off harmful infections, but their role in human ... light on the role of these bacteria, a team ... recently tracked fluctuations in the bacterial populations of two ... in the July 25 issue of the journal ...
(Date:7/25/2014)... University of Leicester has furthered our understanding of ... create new materials using nanosized ,building blocks,. , ... prestigious academic journal Physical Review Letters , ... rich detail the structure and internal atomic motion ... and a single helium atom. , The technique ...
(Date:7/25/2014)... -- Research and Markets  has announced the ... report to their offering. ... Metabonomics is the scientific study of chemical processes ... technique that is being widely used in biology, ... molecules that are present in blood, urine, and ...
(Date:7/25/2014)... According to a new market report ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast, ... estimated at USD 161,056.5 million in 2014 and is ... 2014 to 2020, to reach an estimated value of ... market is witnessing a significant growth due to the ...
Breaking Biology Technology:Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3
... PHILADELPHIA, Aug. 23, 2011 FMC Corporation (NYSE: ... has entered into two exclusive agreements covering global development ... and ornamental markets.  FMC will begin commercialization this year ... start development for new biological standalone and combination products ...
... Additional   Funds to   Broaden   ... , AU$6.25M (US$6.5M) investment by GBS Venture Partners, ... additional Phase 2 studies will run in parallel with planned clinical ... an Australian pain drug development company, today announced it has ...
... not easy, especially for tiny nanowires: With no ... difficult to harness their full potential as effective ... Chemistry Faculty has found a way to grow ... providing, for the first time, the much-needed guidance ...
Cached Biology Technology:FMC Corporation Announces Exclusive Global Development and Supply Agreements for Chr. Hansen Biological Products 2Spinifex Closes AU$18.25M(~US$19M) Expanded Series B Round 2Spinifex Closes AU$18.25M(~US$19M) Expanded Series B Round 3Spinifex Closes AU$18.25M(~US$19M) Expanded Series B Round 4Spinifex Closes AU$18.25M(~US$19M) Expanded Series B Round 5Nanowires get into the groove 2
... has made microcapillary flow cytometry accessible to ... alike will appreciate the latest addition to ... to use, surprising affordable, and very compact ... includes such features as absolute cell counts, ...
...
... and flexibility of the BDTM LSR, the first UV ... The BD LSR II has performance, capabilities, and ... Free up your high-performance cell sorter by moving your ... LSR II. The BD LSR II can be configured ...
... C6 Flow Cytometer System is a full featured, ... including: the C6 Flow Cytometer, CFlow Software, and ... Flow Cytometer System provides all the capabilities of ... of the price. The C6 Flow Cytometer System ...
Biology Products: