Navigation Links
NIH study links high levels of cadmium, lead in blood to pregnancy delay

Higher blood levels of cadmium in females, and higher blood levels of lead in males, delayed pregnancy in couples trying to become pregnant, according to a study by researchers at the National Institutes of Health and other academic research institutions.

Cigarette smoke is the most common source of exposure to cadmium,, a toxic metal found in the earth's crust, which is used in batteries, pigments, metal coatings and plastics. Smokers are estimated to have twice the levels of cadmium as do non-smokers. Exposure also occurs in workplaces where cadmium-containing products are made, and from the air near industrial facilities that emit cadmium. Airborne cadmium particles can travel long distances before settling on the ground or water. Soil levels of cadmium vary with location. Fish, plants, and animals absorb cadmium from the environment, and all foods contain at least low levels of the metal.

Lead, a toxic metal also found in the earth's crust, is used in a variety of products, such as ceramics, pipes, and batteries. Common sources of lead exposure in the United States include lead-based paint in older homes, lead-glazed pottery, contaminated soil, and contaminated drinking water.

Exposure to these metals is known to have a number of effects on human health, but the effects on human fertility have not been extensively studied, especially when studying both partners of a couple.

The study was published online in Chemosphere. The study's principal investigator was Germaine M. Buck Louis, Ph.D., director of the Division of Epidemiology, Statistics, and Prevention Research at the NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Other authors of the study were from the NICHD, the Texas A&M Health Science Center School of Rural Public Health, College Station; The Ohio State University College of Medicine, Columbus; The EMMES Corp. in Rockville, Md.; the National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta; and the Rollins School of Public Health at Emory University, Atlanta.

"Our results indicate that men and women planning to have children should minimize their exposure to lead and cadmium," Dr. Buck Louis said. "They can reduce cadmium exposure by avoiding cigarettes or by quitting if they are current smokers, especially if they intend to become pregnant in the future. Similarly, they can take steps to reduce their exposure to lead based paints, which may occur in older housing, including during periods of home renovation."

To conduct the study, the researchers enrolled 501 couples from four counties in Michigan and 12 counties in Texas, from 2005 to 2009. The women ranged from 18 to 44 years of age, and the men were over 18. Couples provided blood samples for the analysis of three heavy metals. Women kept journals to record their monthly menstrual cycles and the results of home pregnancy tests. The couples were followed until pregnancy or for up to one year of trying.

The researchers ranked the study participants on the basis of their blood levels of lead and cadmium. The researchers also measured the participants' blood mercury levels, but found they were not associated with the length of time couples required to become pregnant. Nearly every study participant had some exposure to these common metals, although blood levels of the metals varied across participants.

Researchers calculated the probability that a couple would achieve pregnancy by levels of blood cadmium and lead with a statistical measure called the fecundability odds ratio. The measure estimates couples' probability of pregnancy each cycle, by their blood concentration of metals. A ratio less than one suggests a longer time to pregnancy, while a ratio greater than one suggests a shorter time to pregnancy. Females' blood cadmium concentration was associated with a ratio below 1 (0.78), which means that the probability of pregnancy was reduced by 22 percent with each increase in the level of cadmium. Males' blood lead exposure also was associated with a ratio below 1 (0.85) with increasing levels, or about a 15 percent reduction in the probability of pregnancy for each increase in the level of blood lead concentrations.

The researchers also calculated a fecundability odds ratio based on both partners' combined lead, cadmium and mercury concentrations. The researchers found a ratio of 0.82 for male lead exposure, representing approximately a 28 percent reduction in the probability of pregnancy for each menstrual cycle, with increasing male blood lead concentration.

"The findings highlight the importance of assessing couples' exposure jointly, in a single, combined measure," Dr. Buck Louis said. "Males matter, because couples' chances of becoming pregnant each cycle were reduced with increasing blood lead concentrations in men."


Contact: Robert Bock or Marianne Glass Miller
NIH/National Institute of Child Health and Human Development

Related biology news :

1. New study sheds light on genetics of rice metabolism
2. Study shows electron-beam irradiation reduces virus-related health risk in lettuce, spinach
3. A zap of cold plasma reduces harmful bacteria on raw chicken in Drexel study
4. Heat and cold damage corals in their own ways, Scripps study shows
5. Satellite study reveals critical habitat and corridors for worlds rarest gorilla
6. Body clock receptor linked to diabetes in new genetic study
7. Genetics study reveals how bacteria behind serious childhood disease evolve to evade vaccines
8. Study pinpoints genetic variation that raises a risk linked to bisphosphonates
9. UMass Amherst ecologists among the first to record and study deep-sea fish noises
10. Coastal storms have long-reaching effects, study says
11. Recent study by Mars, Incorporated and partners underscores importance of metabolism in understanding health benefits of cocoa flavanols
Post Your Comments:
(Date:11/10/2015)... , Nov. 10, 2015  In ... on the basis of product, type, application, ... included in this report are consumables, services, ... report are safety biomarkers, efficacy biomarkers, and ... this report are diagnostics development, drug discovery ...
(Date:11/4/2015)... New York , November 4, 2015 ... to a new market report published by Transparency Market ... Share, Growth, Trends and Forecast 2015 - 2022", the global ... of US$ 30.3 bn by 2022. The market is ... the forecast period from 2015 to 2022. Rising security ...
(Date:10/29/2015)... Oct. 29, 2015 Daon, a global leader ... has released a new version of its IdentityX ... North America have already installed IdentityX ... includes a FIDO UAF certified server component ... to activate FIDO features. These customers include some of ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 25, 2015  PharmAthene, Inc. (NYSE MKT: PIP) announced ... stockholder rights plan (Rights Plan) in an effort to ... (NOLs) under Section 382 of the Internal Revenue Code ... PharmAthene,s use of its NOLs could be substantially limited ... in Section 382 of the Code. In general, an ...
(Date:11/25/2015)... HOLLISTON, Mass. , Nov. 25, 2015 ... a biotechnology company developing bioengineered organ implants for life-threatening ... will present at the LD Micro "Main Event" investor ... PT. The presentation will be webcast live and posted ... also be available at the conference for one-on-one meetings ...
(Date:11/25/2015)... ... November 25, 2015 , ... A long-standing ... Aerospace Professionals (OPBAP) has been formalized with the signing of a Memorandum of ... with OPBAP leaders Capt. Karl Minter and Capt. Albert Glenn Tuesday, November 24, ...
(Date:11/25/2015)... CA (PRWEB) , ... November 25, 2015 , ... ... genomics company uBiome, were featured on AngelList early in their initial angel funding ... an AngelList syndicate for individuals looking to make early stage investments in the ...
Breaking Biology Technology: