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NIH stimulus funding supports Emory biomedical scientists
Date:8/7/2009

Sciences Center. "In addition, it gives some young scientists a chance to advance their careers while pursuing discoveries that could lead to true breakthrough treatments."

"Funds from the stimulus bill will have far-reaching effects," says David Wynes, PhD, Emory's vice president for research. "New equipment, additional postdoctoral trainees and laboratory technicians, and possible new facility space will create opportunities that we can build on in future years after this funding is no longer available."

Examples of stimulus-funded projects at Emory thus far include:

Blocking blood vessel growth in tumors: The creation of new blood vessels can be good a response to exercise or injury or bad, enabling the growth of a tumor. This project examines Syk, a molecule that appears to push blood vessels to grow in response to low oxygen. Finding ways to block such growth signals could generate new tools to fight cancer.

New treatments for epilepsy: Some epilepsy patients cannot control their seizures with drugs. Animal research shows that shutting off a gene called SCN8A can lower susceptibility to seizures. Scientists plan to test a gene-therapy-like technique for shutting off SCN8A in mice, with an eye towards developing similar treatments for humans.

The role of memory T cells in transplant rejection: Memory T cells allow the immune system to respond to infections faster and stronger upon a second encounter, but they also play a big role in rejecting transplanted organs. Scientists will test several molecules found on memory T cells' surfaces as possible handles for manipulating the immune system.

Dietary phosphate and prostate cancer: The nutrient phosphate is an additive in products ranging from soft drinks to meats and bakery goods, but it plays a critical role in regulating cell growth and could encourage tumor formation. This project monitors the influence of dietary phosphate on a mouse model of prosta
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Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

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