Navigation Links
NIH scientists identify gene that could hold the key to muscle repair
Date:4/18/2011

cumstances, the scientists looked to a gene called Ezh2, known to keep the activity of other genes in check. When they genetically inactivated Ezh2 in satellite cells of laboratory mice, the mice failed to repair muscle damage caused by traumatic injury satellite cells could not proliferate.

Ezh2 expression is known to decline during aging, and the new research in mice suggests that therapies to activate Ezh2 and promote satellite cell proliferation might eventually play a role in treating degenerative muscle diseases.

"We will not be able to cure the muscular dystrophies with this approach because the mutation in the gene that causes the diseases would remain. But certainly, if we can extend the period in which the satellite cells proliferate and compensate for the underlying defect, we might increase the lifespan of people with muscular dystrophy. We could certainly increase their quality of life," said Dr. Sartorelli.

Likewise, in the elderly, tweaking the gene in satellite cells would not increase their lifespan, but could increase their quality of life by helping to prevent falls and enabling them to move and walk better and go about their daily activities.

Dr. Sartorelli cautions that while the identification of Ezh2's role is a crucial step, any therapies are still many years away.


'/>"/>

Contact: Trish Reynolds
reynoldsp2@mail.nih.gov
301-496-8190
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gladstone scientists identify genes involved in embryonic heart development
2. Scripps Research scientists identify mechanism of long-term memory
3. Scientists identify a surprising new source of cancer stem cells
4. Scripps Research scientists uncover new DNA role in modifying gene function
5. Outsmarting cancer cells: SLU scientists learn how they spread
6. Scripps Research scientists find dual switch regulates fat formation
7. Scientists make bamboo tools to test theory explaining East Asias Stone Age tool scarcity
8. Scientists exploit ash tree pests chemical communication
9. S.L.E. Lupus Foundation announces new grants to further NYC scientists leadership in lupus research
10. Scientists develop new technology for stroke rehabilitation
11. Common chaperone protein found to work in surprising way, say Scripps Research scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... 2014  The Secure Identity & Biometrics Association ... announce the formation of The Airport Entry and ... Identity and Biometric Entry and Exit Solutions Framework ... support from BORDERPOL, the international non-profit organization that ... expertise regarding border security, traveler and migration systems. ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock ... authentication solutions, and MorphoTrust USA (Safran), ... services, today announced a strategic partnership to offer ... motor vehicle administration (MVA), airport screening and financial ... identity-related solutions, MorphoTrust serves consumers through a nationwide ...
(Date:11/11/2014)... , Nov. 11, 2014  Forensicon, Inc., a ... firm, is pleased to announce the promotion of ... Director of Digital Forensics. In Schiff,s new role as ... the team of digital forensics examiners and provide leadership ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... of protein found within nerve cells are a ... first identified in the early 1900s by German psychiatrist ... a protein called tau cause it to aggregate in ... the tau protein is involved in the formation of ...
... has led to much more severe peatland wildfires and nine ... new research led by a University of Guelph professor. ... the first to investigate the effect of drainage on carbon ... to burning. "Russia, Indonesia and Canada all have abundant ...
... mainland United States known for its tropical smell now has a ... - so called because they tend to invade houses and smell ... And, according to Purdue University entomologist Grzegorz Buczkowski, it doesn,t seem ... house ants in Hawaii are not like they are here in ...
Cached Biology News:Chemical engineers help decipher mystery of neurofibrillary tangle formation in Alzheimer's brains 2Drying intensifying wildfires, carbon release ninefold, study finds 2Pesky ants found in Hawaii demonstrate invasive characteristics 2
(Date:11/18/2014)... 18, 2014  Great Basin Scientific, Inc. (NASDAQ: ... management will host a conference call and webcast to provide ... Thursday, Nov. 20, at 4:30 pm EST time. ... the Company,s recent IPO and would like to provide our ... Ryan Ashton , President and Chief Executive Officer of ...
(Date:11/17/2014)... 17, 2014 Soligenix, Inc. (OTCQB: SNGX) ... developing products that address unmet medical needs in ... today the formation of a Medical Advisory Board ... Company as it advances the Phase 3 clinical ... of cutaneous T-cell lymphoma (CTCL), a rare class ...
(Date:11/15/2014)... Collaborative Consulting, a privately held, employee-based professional services ... Boston Globe’s “Top Places to Work 2014”. Collaborative ... receive the honor. , The Boston Globe’s ‘Tops Places ... most valuable resource: the people who work for them. ... on an array of criteria, including the caliber of ...
(Date:11/15/2014)... Arizona (PRWEB) November 14, 2014 ... , ‘ISCTR’ announced today that the society’s Governing ... J. Rowe, Edwards Lifesciences chief scientific officer and ... chief medical officer, Abbott Vascular. Mr. Rowe ... and medical device development experts. , Dr. ...
Breaking Biology Technology:Great Basin Scientific Announces Conference Call to Provide Update on Corporate Progress 2Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 2Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 3Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 4Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 5Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 6Collaborative Consulting Honored with Boston Globe Top Places to Work 2014 2International Society for Cardiovascular Translational Research Governing Board Adds Medical Industry Leaders 2
... Mass., Jan. 10 Caliper Life,Sciences, Inc. (Nasdaq: ... will,present at the JPMorgan 26th Annual Healthcare Conference ... at 2:00 p.m. PST. Mr.,Hrusovsky will discuss Caliper,s ... top-level revenue performance for 2007., Based on ...
... SEATTLE, Jan. 9 Omeros Corporation announced today that,it ... Exchange,Commission relating to the proposed initial public offering of ... stock to be sold in the offering,will be offered ... as,the sole book-running manager. Pacific Growth Equities, LLC will ...
... Nordisk, a,healthcare company with an 84-year history of ... appointment of Alan C. Moses, M.D. as,vice president, ... medical officer of Novo Nordisk Inc., the company,s ... to integrate the science of discovery with,new drug ...
Cached Biology Technology:Caliper Life Sciences to Present at JPMorgan 26th Annual Healthcare Conference Today 2Omeros Corporation Files Registration Statement for Proposed Initial Public Offering 2Novo Nordisk Appoints Alan C. Moses as Chief Medical Officer Worldwide 2
... Mitochondria Derived Activator of Caspase/DIABLO Liquid. ... 7.5 AVOID FREEZE/THAW CYCLES. Amino acid residues 56 ... terminal His•Tag ® sequence was expressed in ... is released along with cytochrome c ...
... Sheep polyclonal to Decorin ( ... Antigen: Synthetic ... to amino acids 6-19 of Human ... molecule bone proteoglycan II). ...
GLP expression profiling service on the Affymetrix platform. Starting material can be blood, tissue or RNA. 5 day turnaround. Standard and custom post analyses of microarray data available....
... The EasyCount System is a fluorescent ... and live nucleated cells and automatically calculates ... By automating this routine function, the variability ... methods can be eliminated. Using the EasyCount ...
Biology Products: