Navigation Links
NIH scientists identify gene that could hold the key to muscle repair
Date:4/18/2011

Researchers have long questioned why patients with Duchenne muscular dystrophy (DMD) tend to manage well through childhood and adolescence, yet succumb to their disease in early adulthood, or why elderly people who lose muscle strength following bed rest find it difficult or impossible to regain. Now, researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health, are beginning to find answers in a specialized population of cells called satellite cells. Their findings, reported in the journal Genes & Development, suggest a potential therapeutic target for conditions where muscle deterioration threatens life or quality of life.

Key to the development of skeletal muscle of the embryo and fetus, satellite cells continue to actively increase muscle mass through infancy. After that, they decrease in number and become quiescent, or inactive, until they are activated by injury or degeneration to proliferate. The process, which enables the body to repair damaged muscle, works quite well to a point, says Vittorio Sartorelli, M.D., senior investigator in the NIAMS Laboratory of Muscle Stem Cells and Gene Regulation and lead author of the study.

For example, when a young person experiences muscle loss after a period of inactivity, muscle rebuilds as soon as activity is resumed. However, in the elderly, muscles lose that capacity. Similarly, in patients with DMD, the initial phases of muscle degeneration are effectively counteracted by the ability of satellite cells to regenerate.

"That is why people can survive until they are 20 years old without much of a problem, but, at a certain point, satellite cells stop proliferating," said Dr. Sartorelli. "That is the point at which the patient will start developing weakness and problems that will ultimately lead to death."

Suspecting a genetic switch that might turn off satellite cell proliferation in these cir
'/>"/>

Contact: Trish Reynolds
reynoldsp2@mail.nih.gov
301-496-8190
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gladstone scientists identify genes involved in embryonic heart development
2. Scripps Research scientists identify mechanism of long-term memory
3. Scientists identify a surprising new source of cancer stem cells
4. Scripps Research scientists uncover new DNA role in modifying gene function
5. Outsmarting cancer cells: SLU scientists learn how they spread
6. Scripps Research scientists find dual switch regulates fat formation
7. Scientists make bamboo tools to test theory explaining East Asias Stone Age tool scarcity
8. Scientists exploit ash tree pests chemical communication
9. S.L.E. Lupus Foundation announces new grants to further NYC scientists leadership in lupus research
10. Scientists develop new technology for stroke rehabilitation
11. Common chaperone protein found to work in surprising way, say Scripps Research scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... July 24, 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the ... randomized, active control Phase 3 study of Zerenex (ferric ... for the treatment of hyperphosphatemia in patients with end-stage ... binding and iRon delivery with FErric CiTrate in EsrD) ... the American Society of Nephrology ( JASN ). ...
(Date:7/24/2014)... species of fish, according to a new study ... tested fish anti-predator behaviour. , Three-spined sticklebacks ... when exposed to additional noise, whereas no effects ... author Dr Irene Voellmy of Bristol,s School of ... environments have increased substantially during the last few ...
(Date:7/24/2014)... A sake brewery has its own microbial terroir, meaning ... resemble those found in the product, creating the final ... the journal Applied and Environmental Microbiology . This ... census of a sake brewery. , Many sake ... author David A. Mills of the University of California, ...
Breaking Biology News(10 mins):Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4The microbes make the sake brewery 2
... diabetes places a huge burden on its victims and poses ... attacks and stroke cases, but also many other deleterious conditions, ... In Germany alone, some seven million people currently suffer from ... to reach 370 million by the year 2030. Type 2 ...
... A discovery by Monash University scientists could see humble ... ,lab-on-chip, devices capable of detecting diseases such as kidney ... researchers have used ordinary cotton thread and sewing needles ... which is the size of a postage stamp. ...
... may look identicalnot to mention drabto the human eye. But ... are essentially colorblind. A new study published online on February ... reveals that the fish can easily tell one species from ... patterns on their faces. Although scientists have long known ...
Cached Biology News:The pig and its pancreas 2The pig and its pancreas 3How long is a piece of thread? Long enough to save a life 2Fish can recognize a face based on UV pattern alone 2
(Date:7/24/2014)...  ECC West Africa, LLC (ECC) signed a contract ... College Hospital (UCH) Ibadan Board of Management for the ... construct, and operate and maintain a new, state-of-the-art Cancer ... the first of the 4-phase project, ECC will conduct ... UCH Ibadan intends to finance and develop the Cancer ...
(Date:7/24/2014)... at the University of Delaware, is known worldwide ... engineering, environmental sustainability and electronics. , His early ... a well-defined, crystalline structure. At the atomic scale, ... zeolites can separate molecules with size differences of ... a nanometer), making them useful to the chemical ...
(Date:7/24/2014)... 24, 2014 Your cell phone ... modeling lithium-ion battery storage capacity. , New research ... theoretical model created at Lawrence Livermore National ... predicts how carbon components will perform as electrodes. ... the urgent need for higher-performance batteries. Several key ...
(Date:7/24/2014)... 2014 Deep Research Report on Global ... and in-depth research report on Potassium Sulphate ... information, including its definition, classification, application, and industry ... the international market analysis, including China’s domestic market ... environment & economic situation analysis, the influence of ...
Breaking Biology Technology:ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2University of Delaware researcher describes new approach for creating organic zeolites 2Getting More Life out of Lithium-ion Batteries 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4
... Feb. 5 Amicus Therapeutics (Nasdaq: FOLD ) announced ... Crowley as Chairman of the Board in addition to his ... will succeed Donald J. Hayden, Jr. , who will become ... to elect Mr. Crowley as Chairman of the Board reflects our ...
... Science , by researchers at Rothamsted Research (an institute ... Institute, and the Universities of Exeter, Greenwich and York, ... insects to undertake long-distance migrations, and highlights the remarkable ... cold British winters by migrating south in autumn to ...
... 4, 2010 -- Four Oak Ridge National Laboratory researchers ... research grants as part of the Department of Energy,s ... program, funded under the American Recovery and Reinvestment Act ... support exceptional researchers during the crucial early career years, ...
Cached Biology Technology:Amicus Therapeutics Board of Directors Names Chief Executive Officer John F. Crowley Chairman of the Board 2Migrating insects fly in the fast lane 24 ORNL researchers selected for Recovery Act early career funds 24 ORNL researchers selected for Recovery Act early career funds 3
... CromoCenSC is a chromogenic medium for ... of Salmonella (except S. thyphi) and ... ,The detection takes a maximum of ... tests, no sterilization during preparation and ...
Large-capacity refrigerated incubator chamber holds up to 4 independently-operated shakers. Programmable heat, refrigeration, humidifcation are standard. Photosynthetic operation, optional....
...
... (PDF-MALDI) source provides fast, easy, and ultrasensitive ... online separation. Paired with an Agilent 6300 ... Spectrum Mill software, the PDF-MALDI source is ... digests. It provides clean, searchable MS/MS spectra ...
Biology Products: