Navigation Links
NIH scientists describe how anthrax toxins cause illness, death
Date:8/28/2013

Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) and the National Heart, Lung, and Blood Institute, both part of the National Institutes of Health, have identified the cells in two distinct areas of the body that are simultaneously targeted for damage by anthrax toxins, eventually causing illness and sometimes death. Their findings, which appeared online today in Nature, are based on testing in mice. However, the results may contribute to the development of anthrax treatments for humans, the researchers say.

Anthrax disease is caused by the bacterium Bacillus anthracis, which produces two deadly toxins: lethal toxin and edema toxin. When B. anthracis infects a human or animal, both toxins seek out and bind to receptors on the surfaces of human and animal cells. Using two types of laboratory micethose missing the anthrax toxin receptor on a single type of cell or those having the receptor present on a single type of cellthe scientists compared disease progression among the rodents. They concluded that anthrax-induced death is caused primarily by lethal toxin targeting heart cells and muscle cells surrounding blood vessels, and edema toxin targeting liver cells.

These results may help scientists studying anthrax disease in humans. For example, the study authors suggest, knowing the types of cells that anthrax toxins target could spur the development of treatments that reduce damage to those cells.


'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2016)...  Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... gut microbiome, today announced the pricing of an ... common stock and warrants to purchase 50,000,000 shares ... the public of $1.00 per share and accompanying ... offering, excluding the proceeds, if any from the ...
(Date:6/27/2016)... Research and Markets has announced the addition of the ... The report forecasts the biometrics ... a CAGR of 12.28% during the period 2016-2020. ... with inputs from industry experts. The report covers the market landscape ... includes a discussion of the key vendors operating in this market. ...
(Date:6/21/2016)... 21, 2016 NuData Security announced today that ... of principal product architect and that Jon ... customer development. Both will report directly to ... moves reflect NuData,s strategic growth in its product ... customer demand and customer focus values. ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... 8, 2016   Biocept, Inc . (NASDAQ: ... of clinically actionable liquid biopsy tests to improve ... data featuring its Target Selector™ Circulating Tumor Cell ... the detection of actionable biomarkers in patients with ... by Sara Cannon Research Institute (SCRI), the research ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... concluded that “in the setting of previously treated, advanced pancreatic cancer, liquid biopsies ... the optimal patient population and timing of blood sampling may improve the value ...
(Date:12/7/2016)... Neogen Corporation (NASDAQ: NEOG ) ... as its chief science officer — a new ... at Neogen effective Jan. 1. Kephart has ... unit of Thermo Fisher Scientific, as well as animal ... extensive industry experience also includes the management of a ...
(Date:12/7/2016)... Dec. 7, 2016 /PRNewswire/ - Zenith Capital Corp. ("Zenith" or the ... be presented at the Company,s Annual and Special Meeting. ... will take place on Thursday, December 15, 2016 at ... (Room EC1040), 4825 Mount Royal Gate SW, ... notice of meeting and management information circular, containing the matters ...
Breaking Biology Technology: