Navigation Links
NIH scientists describe how anthrax toxins cause illness, death
Date:8/28/2013

Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) and the National Heart, Lung, and Blood Institute, both part of the National Institutes of Health, have identified the cells in two distinct areas of the body that are simultaneously targeted for damage by anthrax toxins, eventually causing illness and sometimes death. Their findings, which appeared online today in Nature, are based on testing in mice. However, the results may contribute to the development of anthrax treatments for humans, the researchers say.

Anthrax disease is caused by the bacterium Bacillus anthracis, which produces two deadly toxins: lethal toxin and edema toxin. When B. anthracis infects a human or animal, both toxins seek out and bind to receptors on the surfaces of human and animal cells. Using two types of laboratory micethose missing the anthrax toxin receptor on a single type of cell or those having the receptor present on a single type of cellthe scientists compared disease progression among the rodents. They concluded that anthrax-induced death is caused primarily by lethal toxin targeting heart cells and muscle cells surrounding blood vessels, and edema toxin targeting liver cells.

These results may help scientists studying anthrax disease in humans. For example, the study authors suggest, knowing the types of cells that anthrax toxins target could spur the development of treatments that reduce damage to those cells.


'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... researchers have published soil organic carbon sequestration rates. ... organic carbon can be sequestered by simply switching from ... there is a growing body of research with evidence ... cover crops, small grains, and forages may not be ... , "Some studies have shown that both moldboard and ...
(Date:4/18/2014)... Calif. A team of researchers led by ... been selected to receive a $7.5 million Department of ... simple and basic scientific foundations for the predictable design ... a wide diversity of structures from plants and animals, ... are taking what biological systems have constructed over millions ...
(Date:4/17/2014)... Suddenly there was a word for chili peppers. Information ... along with a study of the appearance of words ... understand where jalapeos were domesticated and highlight the value ... (Kraig Kraft et al.) of nine papers presented in ... the National Academy of Sciences on plant and ...
Breaking Biology News(10 mins):Researchers question published no-till soil organic carbon sequestration rates 2Researchers question published no-till soil organic carbon sequestration rates 3Researchers question published no-till soil organic carbon sequestration rates 4Mantis shrimp, toucan and trilobite, oh my 2Mantis shrimp, toucan and trilobite, oh my 3Chickens to chili peppers 2Chickens to chili peppers 3
... largest mass extinction which killed more than 70 percent ... still taking lives today. That,s the conclusion of a new ... content of coal in one region of China may be ... high rates of lung cancer. The study, which helps solve ...
... reporting new evidence that certain high blood pressure drugs may ... cause of vision loss in people with diabetes. The study, ... lead to new ways to prevent or treat the sight-threatening ... of Proteome Research , a monthly publication. Edward ...
... we chew our food? Research has shown that it is not, ... enough to swallow without choking. Biomechanics, who have modelled the ... shown that we actually chew our food to ensure it is ... in January,s Physics World , Dr Roland Ennos, a biomechanic ...
Cached Biology News:How people work ... and the fingerprint mystery 2
(Date:1/14/2014)... 2014 EquitiesIQ, a leading informational research ... Alliqua is an emerging biomedical company acquiring, developing, manufacturing, ... market. , Free report download: http://equitiesiq.com/reports/alliqua/ , ... management team and Board, which launched the company’s new ...
(Date:1/14/2014)... In recent years, growing suspicion about ... product development and promotion has led to unprecedented levels ... by concerns about the insidious impact of commercialization of ... fines to the world’s biggest pharmas for illegal marketing ...
(Date:1/14/2014)... UK (PRWEB) January 13, 2014 Bob ... with more than 20 years in the industry, has ... photonics . Hainsey will serve as the society’s Science ... Dr. Hainsey join SPIE as our Technology Strategist, further ...
(Date:1/14/2014)... BioMedomics, Inc. , a Point of Care ... novel disease specific POC tests, announced today that it has ... of $690,000. The investment is from private investors and is ... of private investors has significant successful experience in early investments ...
Breaking Biology Technology:EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2BioMedomics, Inc. Closes $690K Round of Financing 2
... economy by producing and attracting human capital. Is America ... opens Richard Floridas article, Americas Looming Creativity Crisis, which ... Business Review. (The full text of the article can ... well known for his writings about the economic importance ...
... the State University of New York in Albany, Carlos Santiago ... led to the creation of a $1.5 billion center of ... Santiago sees no reason why UW-Milwaukee can't aspire to do ... the new chancellor of UW-Milwaukee, is determined to build the ...
... star. In this case, he was a world-renowned scientist for ... around to sing his deserving praise. , ,I only became ... of biotech scientist Benjamin Frydman, who passed away due to ... by birth, Frydman was a founder of Wisconsin biotech company ...
Cached Biology Technology:Is America Inc.s brand diminishing? 2Is America Inc.s brand diminishing? 3Is America Inc.s brand diminishing? 4UW-Milwaukee Chancellor Santiago determined to build on research base 2UW-Milwaukee Chancellor Santiago determined to build on research base 3An Argentine biotechman in Wisconsin 2An Argentine biotechman in Wisconsin 3An Argentine biotechman in Wisconsin 4
acridine orange 10-nonyl bromide (nonyl acridine orange)...
anti-dansyl, rabbit IgG fraction *1 mg/mL* Secondary Detection; Anti-Dye and Anti-Hapten Antibodies...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
MOUSE ANTI RAT RT1Ac Immunogen: PHA activated rat lymphocytes...
Biology Products: