Navigation Links
NIH recognizes Clemson nanotechnology for molecule tracking

CLEMSON The National Institutes of Health has awarded two Clemson chemistry faculty nearly $1 million to detect, track and image the interior of cells. Jason McNeill and Ken Christensen will receive the $960,000 grant to develop polymer dot nanoparticles for tracking single molecules in live cells.

The development of techniques for following individual molecules within cells is important because scientists could use this technology to determine the bodys defenses against invading viruses and bacteria or how proteins operate within the cell. The technology also could help doctors pinpoint the exact location of cancer cells in order to better focus treatment and minimize damage to healthy tissue. Other possible targets of investigation include plaques and fibrils in the brain associated with Alzheimer's disease and mad cow disease.

For the last decade, scientists around the globe have worked to develop and refine highly fluorescent nanoparticles that light up when bathed with laser light, enabling scientists to pinpoint the location of an individual molecule inside a living cell or tissue.

Recently, Clemson chemists developed novel, highly fluorescent nanoparticles called polymer dots that can be attached to individual proteins, DNA or invading microbes. According to chemist Jason McNeill, the polymer dot particles are hundreds or thousands of times brighter than conventional fluorescent dyes.

We were initially interested in developing polymer semiconductor nanoparticles for making inexpensive, highly efficient solar cells and light-emitting displays. When we aimed a laser at the particles in a microscope, we were surprised to see individual particles light up very brightly, said McNeill.

When I heard about these extremely bright particles, my group was very interested in working with Dr. McNeill to push this technology into live cell imaging, said Christensen. Biology is often driven by new discoveries in chemistry and physics and these polymer dots will definitely impact our studies of cellular biology.

The two chemists credit the highly collaborative, multidisciplinary environment at Clemson as a key factor in this new frontier in nanotechnology.

Details of the nanoparticle technology were recently presented at the 2007 national meeting of the American Chemical Society in Boston and have been published in the Journal of the American Chemical Society, Langmuir and in the Journal of Physical Chemistry.


Contact: Jason McNeill
Clemson University

Related biology news :

1. What recognizes what in plant disease resistance?
2. Mimicking how the brain recognizes street scenes
3. New details on how the immune system recognizes influenza
4. Revolutionary nanotechnology illuminates brain cells at work
5. Nanotechnology to provide portable genetic risk detection
6. Nanotechnology may find disease before it starts
7. Nanotechnology being used to improve biocompatibility of human prosthetics and implants
8. Silver bullet: UGA researchers use laser, nanotechnology to rapidly detect viruses
9. Nanotechnology propels advances in regenerative medicine research
10. New nanotechnology able to examine single molecules, aiding in determining gene expression
11. Nanotechnology shows promise as next wrinkle fighter
Post Your Comments:
(Date:10/29/2015)... ARBOR, Mich. , Oct. 29, 2015 /PRNewswire/ ... Eurofins Genomics for U.S. distribution of its DNA ... DNA-seq kit and Rubicon,s new ThruPLEX Plasma-seq kit. ... to enable the preparation of NGS libraries for ... plasma for diagnostic and prognostic applications in cancer ...
(Date:10/27/2015)... , Oct. 27, 2015 In the present ... of concern for various industry verticals such as banking, ... to the growing demand for secure & simplified access ... ,sectors, such as hacking of bank accounts, misuse of ... equipment such as PC,s, laptops, and smartphones are expected ...
(Date:10/26/2015)... LAS VEGAS , Oct. 26, 2015 ... an innovator in modern authentication and a founding member ... launch of its latest version of the Nok Nok™ ... to use standards-based authentication that supports existing and emerging ... Suite is ideal for organizations deploying customer-facing applications that ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015 HemoShear Therapeutics, ... discovering drugs for metabolic disorders, announced today the ... its Board of Directors (BOD). Mr. Watkins is ... Human Genome Sciences (HGS), and also served as ... Jim Powers , Chairman and CEO of ...
(Date:11/24/2015)... , November 24, 2015 , ... in a European healthcare ... the companies will work closely together in identifying European breakthrough ... medical need. The collaboration is underpinned by a significant investment ... This is the first investment by Bristol-Myers Squibb in a ...
(Date:11/24/2015)... According to two new studies, fewer men are ... that many doctors, scientists, and public health experts have been ... PSA tests being done, will there be more men dying ... Samadi, "Despite the efforts made in regards to early ... cancer cause of death in men, killing approximately 27,500 men ...
(Date:11/23/2015)... THOUSAND OAKS, Calif., Nov. 23, 2015   Ceres, ... company, announced today financial results for the fiscal year ... its business. --> --> ... on commercializing forage and feed products with a better ... the company signed distribution agreements with several leading crop ...
Breaking Biology Technology: