Navigation Links
NIH recognizes Clemson nanotechnology for molecule tracking

CLEMSON The National Institutes of Health has awarded two Clemson chemistry faculty nearly $1 million to detect, track and image the interior of cells. Jason McNeill and Ken Christensen will receive the $960,000 grant to develop polymer dot nanoparticles for tracking single molecules in live cells.

The development of techniques for following individual molecules within cells is important because scientists could use this technology to determine the bodys defenses against invading viruses and bacteria or how proteins operate within the cell. The technology also could help doctors pinpoint the exact location of cancer cells in order to better focus treatment and minimize damage to healthy tissue. Other possible targets of investigation include plaques and fibrils in the brain associated with Alzheimer's disease and mad cow disease.

For the last decade, scientists around the globe have worked to develop and refine highly fluorescent nanoparticles that light up when bathed with laser light, enabling scientists to pinpoint the location of an individual molecule inside a living cell or tissue.

Recently, Clemson chemists developed novel, highly fluorescent nanoparticles called polymer dots that can be attached to individual proteins, DNA or invading microbes. According to chemist Jason McNeill, the polymer dot particles are hundreds or thousands of times brighter than conventional fluorescent dyes.

We were initially interested in developing polymer semiconductor nanoparticles for making inexpensive, highly efficient solar cells and light-emitting displays. When we aimed a laser at the particles in a microscope, we were surprised to see individual particles light up very brightly, said McNeill.

When I heard about these extremely bright particles, my group was very interested in working with Dr. McNeill to push this technology into live cell imaging, said Christensen. Biology is often driven by new discoveries in chemistry and physics and these polymer dots will definitely impact our studies of cellular biology.

The two chemists credit the highly collaborative, multidisciplinary environment at Clemson as a key factor in this new frontier in nanotechnology.

Details of the nanoparticle technology were recently presented at the 2007 national meeting of the American Chemical Society in Boston and have been published in the Journal of the American Chemical Society, Langmuir and in the Journal of Physical Chemistry.


Contact: Jason McNeill
Clemson University

Related biology news :

1. What recognizes what in plant disease resistance?
2. Mimicking how the brain recognizes street scenes
3. New details on how the immune system recognizes influenza
4. Revolutionary nanotechnology illuminates brain cells at work
5. Nanotechnology to provide portable genetic risk detection
6. Nanotechnology may find disease before it starts
7. Nanotechnology being used to improve biocompatibility of human prosthetics and implants
8. Silver bullet: UGA researchers use laser, nanotechnology to rapidly detect viruses
9. Nanotechnology propels advances in regenerative medicine research
10. New nanotechnology able to examine single molecules, aiding in determining gene expression
11. Nanotechnology shows promise as next wrinkle fighter
Post Your Comments:
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: ... to provide their customers enhanced security to access ...
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
(Date:4/13/2016)... -- IMPOWER physicians supporting Medicaid patients in Central ... in telehealth thanks to a new partnership with higi. ... patients can routinely track key health measurements, such as ... when they opt in, share them with IMPOWER clinicians ... retail location at no cost. By leveraging this data, ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... 24, 2016  Regular discussions on a range of subjects ... the two entities said Poloz. Speaking at a ... , he pointed to the country,s inflation target, which ... "In certain areas ... have common economic goals, why not sit down and address ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a leader ... “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, ... providing practical tips, tools, and strategies for clinical researchers. , “The landscape of ...
(Date:6/23/2016)... 23, 2016 A person commits a crime, and ... to track the criminal down. An outbreak of ... Drug Administration (FDA) uses DNA evidence to track down the ... Sound far-fetched? It,s not. The FDA has increasingly used a ... of foodborne illnesses. Put as simply as possible, whole genome ...
(Date:6/23/2016)... -- The Biodesign Challenge (BDC), a university competition that asks ... systems and biotechnology, announced its winning teams at the ... York City . The teams, chosen ... MoMA,s Celeste Bartos Theater during the daylong summit. Keynote ... of architecture and design, and Suzanne Lee , ...
Breaking Biology Technology: