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NIH ramps up Human Microbiome Project

Julie Segre, Ph.D., National Human Genome Research Institute, Bethesda, Md.
Skin and nose: Atopic Dermatitis, Immunodeficiency Syndromes
$3.1 million (3 years)
The goal of this study is to examine the microbiomes of the skin and nose in patients with an inflammatory skin disease called atopic dermatitis. Researchers will look for associations between the microbiomes, genetic factors associated with atopic dermatitis, and with immunodeficiency syndromes.

Phillip I. Tarr, M.D., Washington University School of Medicine, St. Louis
Digestive tract: Neonatal Necrotizing Enterocolitis
$5.2 million (3 years)
This group of researchers will examine the potential connection between the intestinal microbiome and the development of neonatal necrotizing enterocolitis, a gastrointestinal disorder in premature infants, in which portions of the bowel undergo tissue death.

James Versalovic, M.D., Ph.D., Baylor College of Medicine, Houston
Digestive tract: Pediatric Irritable Bowel Syndrome (IBS)
$3.4 million (3 years)
This project will examine the composition of the intestinal microbiome and possible connections with irritable bowel syndrome in children.

Gary D. Wu, M.D., University of Pennsylvania School of Medicine, Philadelphia
Digestive tract: Crohn's Disease
$1.1 million (1 year)
In children, Crohn's disease, a form of inflammatory bowel disease, is clinically treated through diet. This team will investigate whether these specialized diet regimes work by altering the composition of the intestinal microbiome. Partial funding for this project will be provided by NIH's Office of Dietary Supplements.

Vincent B. Young, M.D., Ph.D., University of Michigan, Ann Arbor
Digestive tract: Ulcerative Colitis
$8.2 million (3 years)
Some patients who suffer from ulcerative colitis, a type of inflammatory bowel disease that causes inflammation and sores in the lining of the

Contact: Geoff Spencer
NIH/National Human Genome Research Institute

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