Navigation Links
NIH grants will advance studies of the form and function of proteins
Date:9/30/2010

The National Institutes of Health has awarded 23 grants for structural biology research totaling up to $290 million over five years. The projects will focus on determining the shapes and functions of proteins important in biology and medicine.

The awards are part of the Protein Structure Initiative (PSI), an effort that started in 2000 with the main goal of developing highly efficient, or high-throughput, methods for revealing the structures of many different proteins. The structures help scientists answer questions about protein biology and model other structures.

With these new grants, the PSI begins its third five-year phase, PSI:Biology. A key aim is to utilize the high-throughput methods developed during the PSI's first decade to generate protein structures for functional studies.

"The PSI has been incredibly successful in establishing high-throughput pipelines that have led to more than 5,000 structures, most unlike any we've seen before," said Jeremy M. Berg, Ph.D., director of NIH's National Institute of General Medical Sciences, which funds the PSI. "Now it's time to deploy these capabilities so we can advance our understanding of the role proteins play in health and disease."

Four large-scale PSI:Biology centers will operate pipelines for determining protein structures nominated by the scientific community or identified by collaborating biologists funded by PSI:Biology grants. The centers, all established during the first phase of the PSI, are based in California, Illinois, New Jersey and New York and will receive up to $140 million in funding.

These centers will partner with eight groups of researchers that require the determination of many protein structures to understand biological processes or a molecule's function. These grants total up to $75 million.

For example, John Markley, Ph.D., at the University of Wisconsin-Madison will work with the large-scale centers to map all the unique proteins associated with mitochondria, the energy factories of cells that are also involved in a number of human diseases.

PSI:Biology also will support nine centers for determining membrane protein structures. These proteins, embedded in the membrane of our cells, are important because they enable our nerves, muscles and hormones to do their jobs. Scientists, however, can't easily visualize their three-dimensional shapes to better understand how these proteins function. The membrane protein centers, similar to the large-scale centers, will focus on solving the structures by developing highly efficient methods and by collaborating with PSI:Biology partners as well as scientists outside the research network. These centers will receive up to $75 million.

"The value of membrane proteins in biology and medicine has been clear for a long time, and now we need to take a major step toward making membrane protein structure determination better, faster and cheaper, just as the PSI has done for many other types of proteins," said Ward Smith, Ph.D., PSI director.

For instance, the membrane protein center led by Ray Stevens, Ph.D., at the Scripps Research Institute in La Jolla, Calif., will focus on a special class of membrane proteins called G protein-coupled receptors (GPCRs) that serve as the target for more than half of all therapeutic drugs. Stevens will develop new methods and technologies for generating high-resolution structures of nearly two dozen GPCRs from a wide range of organisms, including humans, for use in both basic and applied biomedical research.

For the complete list of awards, see the PSI:Biology Network page at http://www.nigms.nih.gov/Initiatives/PSI/psi_biology/.

Additional investigators will join the PSI:Biology network through ongoing funding opportunities to partner with the high-throughput centers or to develop new methods and approaches for protein modeling and structure determination.

Two other key components of PSI:Biology are the PSI Structural Biology Knowledgebase, which collects and disseminates PSI data, proteins, publications, technologies and other developments, and the PSI Materials Repository, which centralizes, maintains and distributes vectors and clones produced by PSI investigators. Both resources were established during the second PSI phase to serve the broader scientific community.


'/>"/>

Contact: Emily Carlson
carlsone@nigms.nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
Source:Eurekalert  

Related biology news :

1. NIH awards Muscular Dystrophy Cooperative Research Center grants
2. Iowa State awards grants to develop health, energy and research technologies
3. 5 UM Rosenstiel School students receive NSF grad reserach grants
4. UC Riverside receives 6 grants for tobacco-related research
5. Carnegie Mellons Yoed Rabin receives grants
6. LSU researchers secure NSF rapid response grants to study impact of oil spill
7. The Samuel Waxman Cancer Research Foundation awards $1.54 million in research grants for 2010-2011
8. CIMIT announces $3 million in medical research grants
9. NHLBI grants $1.47 million to study red blood cell transfusion storage times and bioactivity
10. NIH grants K-State researcher nearly $1.5 million to study antibiotic-resistant bacteria
11. Autism Speaks awards 16 new research grants funding more than $5 million over next 3 years
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIH grants will advance studies of the form and function of proteins
(Date:6/30/2017)... June 30, 2017 Today, American Trucking ... supplier of face and eye tracking software, became ... provider program. "Artificial intelligence and ... to monitor a driver,s attentiveness levels while on ... able to detect fatigue and prevent potential accidents, ...
(Date:5/16/2017)... , May 16, 2017   Bridge Patient ... organizations, and MD EMR Systems , an ... partner for GE, have established a partnership to ... product and the GE Centricity™ products, including Centricity ... These new integrations will allow ...
(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... UK (PRWEB) , ... September 21, 2017 , ... ... a QuintilesIMS company, who enable the world’s most progressive pharma and biotech organizations ... clinical trials at top pharma and biotech events in Q4. , DrugDev will ...
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... ... scaffold technology, today announced the election of Paul Hermes, Entrepreneur in Residence at ... , Biorez has developed a proprietary, tissue-engineered scaffold for anterior cruciate ligament ...
(Date:9/20/2017)... PA and College Station, TX (PRWEB) , ... ... ... IPS-Integrated Project Services, LLC (IPS), a leading global provider of engineering, ... Inc. the leading provider of prefabricated cleanrooms, today announced the unveiling of ...
(Date:9/20/2017)... CA (PRWEB) , ... September 20, 2017 , ... ... interest organization focused on molecular manufacturing and other transformative technologies, announced the winners ... for Experiment and the other for Theory in nanotechnology/molecular manufacturing. , Established in ...
Breaking Biology Technology: