Navigation Links
NIH grants up to $28 million to group led by Scripps Research for work on ebola treatment
Date:3/20/2014

LA JOLLA, CA March 20, 2014 The National Institutes of Health (NIH) has awarded a five-year grant of up to $28 million to establish a new center for excellence to find an antibody "cocktail" to fight the deadly Ebola virus. The project, which involves researchers from 15 institutions, will be led by Erica Ollmann Saphire, professor at The Scripps Research Institute (TSRI).

"It's a global collaboration," said Saphire. "Everyone in the field got on the same page to collaborate on a set of definitive experiments."

Ebola virus causes an extremely virulent disease that leads to death in 25 to 90 percent of cases. Outbreaks of the fast-moving virus, which spreads via the blood or other bodily fluids of an infected person, have occurred in Uganda and the Democratic Republic of Congo in recent years.

For decades, scientists thought no antibodies were effective against Ebola virus, but in 2012, research from the U.S. Army Medical Research Institute of Infectious Diseases showed that a mix of antibodies can stop the virus. Other labs around the world were simultaneously testing other such antibody cocktails with success.

Today, a whole menu of antibodies have been identified as potentially therapeutic, and researchers are eager to figure out which combinations are most effective and why. Antibodies are currently thought to be the best strategy for treating rare and deadly viruses such as Ebola because they are effective even a couple of days after exposure, a time period during which a person could be airlifted to a hospital for treatment.

With $2.5 million of the grant going to Saphire's laboratory, her team will use a technique called X-ray crystallography to study the structure of the antibodies and how they bind to the virus.

"The structures will provide an essential map for understanding how these antibodies work," Saphire said. "If we understood why some are more effective than others, and which groupings gave better synergy, we could put together a better cocktail."

One unique aspect of this program is that nearly everyone in the field is contributing antibodies. "It will not be this lab's cocktail versus that lab's cocktail," Saphire said, "but an agreement, based upon a blinded study, that what we've put together is the best treatment possible from what is available in the world."

Funding from the grant will also go to TSRI Assistant Professor Andrew Ward for studies using electron microscopy, a different technique for studying molecular structures. TSRI Professor Dennis Burton will contribute antibodies for the study.

Another part of the program is to develop antibody cocktails to fight other hemorrhagic fever viruses such as Marburg, Sudan and Lassa viruses.

The other institutions and scientists on the NIH National Institute of Allergy and Infectious Diseases (NIAID) Centers for Excellence in Translational Research (CETR) program grant, number U19AI109762, include Gary Kobinger at Public Health Agency of Canada, John Dye at U.S. Army Medical Research Institute of Infectious Diseases, Kartik Chandran and Jonathan Lai at Albert Einstein College of Medicine of Yeshiva University, Leslie Lobel at Ben Gurion University, Julius Lutwama at Uganda Virus Research Institute, Robert Garry and James Robinson at Tulane University, Thomas Geisbert at University of Texas Medical Branch, Yoshihiro Kawaoka at University of WisconsinMadison and Gene Olinger at NIAID. Biopharmaceutical companies on the grant include Mapp Biopharmaceutical (Larry Zeitlin), Zalgen labs (Luis Branco) and Cangene (Cory Nykiforuk).


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Related biology news :

1. Jump start for frontier projects: The 2014 HFSP Research Grants
2. INRS receives 7 NSERC Strategic Project Grants
3. Damon Runyon Cancer Research Foundation grants prestigious awards to 20 top young scientists
4. Life Sciences Discovery Fund announces R&D grants
5. 6 Installation Grants awarded
6. Dynasils RMD Subsidiary Awarded $4 Million in Technology Development Grants by U.S. Department of Energy
7. NSF, with interagency and international partners, makes first round of grants to understand Arctic sustainability
8. 2 grants to UC Riverside boost scientists efforts in developing improved cowpea varieties
9. NSF awards grants for deployment of new observing system in the North Atlantic Ocean
10. Entomological Society of America names winners of 2013 student travel grants
11. CWRU grants Disease Diagnostic Group option on malaria diagnostic device
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIH grants up to $28 million to group led by Scripps Research for work on ebola treatment
(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
(Date:6/9/2016)... in attendance control systems is proud to announce the introduction of fingerprint attendance control ... right employees are actually signing in, and to even control the opening of doors. ... ... ... Photo - ...
(Date:6/7/2016)... 2016  Syngrafii Inc. and San Antonio Credit ... includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution ... will result in greater convenience for SACU members ... maintaining existing document workflow and compliance requirements. ... Highlights: ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The ... is proud to add Target to its list of well-respected retailers. This list ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, ... microbial test has received AOAC Research Institute approval 061601. , “This is another ... year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software company, ... Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , “I ... President and COO of STACS DNA. “In further expanding our capacity as a scientific ...
(Date:6/23/2016)... 23, 2016 On Wednesday, June 22, ... down 0.22%; the Dow Jones Industrial Average edged 0.27% lower ... 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on the following ... Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing ...
Breaking Biology Technology: