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NIH grant funds Boston College research into illnesses afflicting people living with HIV
Date:2/10/2013

n that serve as viral reservoirs and reveal how these viral stores are established and maintained in the brain.

The team will use traditional ART drugs and a new orally administered form of a drug that specifically targets infected monocytes and macrophages. It would be the first time researchers have paired another drug with traditional ART in an effort to target the macrophage reservoir of HIV.

In addition, the Williams research team will use the twin therapeutics to target viral cells that attempt to migrate from the brain and back into the body, where they can serve as a source of virus that can re-seed the body.

Earlier research by the lab has effectively marked a special population of brain macrophages and allowed researchers to track these cells as they travel via the lymphatic system through cranial nerves and sinuses. Williams and colleagues at the University of California San Francisco hope to show the new drug and ART can stop the brain-to-body migration of the virus in patients with HIV.


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Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert  

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