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NIH funds work at WPI on regenerating heart tissue and preventing urinary tract infections
Date:5/29/2009

the molecular mechanisms involved in that initial latching-on process, using atomic force microscopy to measure the forces involved. The aim is to establish the optimal cranberry juice dose and exposure time to prevent bacterial adhesion. As part of the new study, Camesano will collaborate with Joseph Grocela, MD, a urologist and clinical researcher at the Massachusetts General Hospital, who will provide samples of epithelial cells taken from women who suffer from chronic urinary tract infections (UTIs). Camesano's lab will observe how the cells react when they are challenged by E.coli and treated with cranberry juice. The goal is to develop a new therapy for UTIs that does not rely on antibiotics.

Gaudette's lab explores the potential for human mesenchymal stem cells (hMSCs), which come from the bone marrow, to regenerate cardiac tissue, thereby helping a damaged heart beat more effectively. Heart attacks cause significant scaring of cardiac tissue, which in turn prevents the scarred area of the heart from contracting to pump blood. Recent studies by Gaudette and others have shown that when hMSCs are injected into a damaged heart, they help improve cardiac function. Working with WPI colleagues George Pins, PhD, associate professor of biomedical engineering, and Marsha Rolle, PhD, assistant professor of biomedical engineering, Gaudette developed a system for seeding biopolymer microthreads with hMSCs, then stitching those threads directly into a damaged heart. The technique significantly improves the ability to place the hMSCs at precise points in the heart to improve function in the damaged area. The new study aims to develop processes for maximizing the number of hMSCs that can be loaded onto the threads, and then to study the effect of the cells on cardiac function in a rat model.


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Contact: Michael Cohen
mcohen@wpi.edu
508-868-4778
Worcester Polytechnic Institute
Source:Eurekalert

Page: 1 2

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