Navigation Links
NIH funds work at WPI on regenerating heart tissue and preventing urinary tract infections
Date:5/29/2009

WORCESTER, Mass. May 28, 2009 Congressman James McGovern, D-Massachusetts, today announced National Institutes of Health (NIH) awards for two researchers at Worcester Polytechnic Institute's Life Sciences and Bioengineering Center at Gateway Park.

Glenn Gaudette, PhD, assistant professor of biomedical engineering at WPI, will receive $403,000 over two years to advance his work using bone marrow derived stem cells to restore function to damaged hearts. Terri Camesano, PhD, associate professor of chemical engineering at WPI, will receive $218,000 over two years to continue her studies of how cranberry juice prevents urinary tract infections. The grants are the first NIH awards for both Gaudette and Camesano, marking an important milestone for the investigators.

"I am pleased to see the NIH continues to recognize the vital research being done at WPI," said Congressman McGovern. "The NIH is the gold-standard for biomedical research in the United States, and these awards further extend Worcester's position as a leading center for the life sciences."

Commenting on the new awards and the growing concentration of NIH funded research at the university, W. Grant McGimpsey, WPI's associate provost for research and graduate studies ad interim, said "receiving NIH funding, after a rigorous review from their peers, is a major achievement for our young investigators. It validates the scholarship and creativity of their work. More important, though, is the progress these and other exciting research programs at WPI are making to help translate basic science discoveries into potential therapies and technologies that will help people."

In previous studies, Camesano has shown that cranberry juice hinders the ability of the bacteria E.coli to adhere to the epithelial cells that line the interior of the urinary tract. Bacterial adhesion is the first step toward infection. In the new study, Camesano's team will analyze how cranberry juice affects the molecular mechanisms involved in that initial latching-on process, using atomic force microscopy to measure the forces involved. The aim is to establish the optimal cranberry juice dose and exposure time to prevent bacterial adhesion. As part of the new study, Camesano will collaborate with Joseph Grocela, MD, a urologist and clinical researcher at the Massachusetts General Hospital, who will provide samples of epithelial cells taken from women who suffer from chronic urinary tract infections (UTIs). Camesano's lab will observe how the cells react when they are challenged by E.coli and treated with cranberry juice. The goal is to develop a new therapy for UTIs that does not rely on antibiotics.

Gaudette's lab explores the potential for human mesenchymal stem cells (hMSCs), which come from the bone marrow, to regenerate cardiac tissue, thereby helping a damaged heart beat more effectively. Heart attacks cause significant scaring of cardiac tissue, which in turn prevents the scarred area of the heart from contracting to pump blood. Recent studies by Gaudette and others have shown that when hMSCs are injected into a damaged heart, they help improve cardiac function. Working with WPI colleagues George Pins, PhD, associate professor of biomedical engineering, and Marsha Rolle, PhD, assistant professor of biomedical engineering, Gaudette developed a system for seeding biopolymer microthreads with hMSCs, then stitching those threads directly into a damaged heart. The technique significantly improves the ability to place the hMSCs at precise points in the heart to improve function in the damaged area. The new study aims to develop processes for maximizing the number of hMSCs that can be loaded onto the threads, and then to study the effect of the cells on cardiac function in a rat model.


'/>"/>

Contact: Michael Cohen
mcohen@wpi.edu
508-868-4778
Worcester Polytechnic Institute
Source:Eurekalert

Related biology news :

1. Keck Foundation funds study of biological interactions with nanomaterials
2. Genes and environment grant funds close look at nature-nurture overlap in common diseases
3. NHGRI funds new Centers for Excellence in Ethical, Legal and Social Implications Research
4. USDA Cooperative Agreement funds mosquito project at Rutgers
5. BP funds scholarship for University of Houston to help fill industry ranks
6. OCAST funds OSU projects with commercial viability
7. BP funds energy scholarships for K20 scholars
8. National Science Foundation funds research addressing enduring questions of life
9. W.M. Keck Foundation grant funds reproductive science research
10. Michael J. Fox Foundation Funds $1.1 Million for Cutting-edge Approaches to Parkinsons Disease
11. EPA funds ground-breaking Lyme disease research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... NEW YORK , June 2, 2016   The ... (Weather), is announcing Watson Ads, an industry-first capability in which ... advertising, by being able to ask questions via voice or ... Marketers have long ... with the consumer, that can be personal, relevant and valuable; ...
(Date:6/1/2016)... , June 1, 2016 ... in Election Administration and Criminal Identification to Boost Global ... a recently released TechSci Research report, " Global Biometrics ... Region, Competition Forecast and Opportunities, 2011 - 2021", the ... billion by 2021, on account of growing security concerns ...
(Date:5/20/2016)... MINNEAPOLIS , May 20, 2016  VoiceIt ... technology partnership with VoicePass. By working ... user experience.  Because VoiceIt and VoicePass take slightly ... two engines increases both security and usability. ... expressed excitement about this new partnership. ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... Mosio, a leader in clinical research patient ... and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the hurdle ... and strategies for clinical researchers. , “The landscape of how patients receive and ...
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
(Date:6/23/2016)... ... ... In a new case report published today in STEM CELLS Translational Medicine, doctors ... being treated for breast cancer benefitted from an injection of stem cells derived from ... frequent side effect of cancer treatment. , Lymphedema refers to the swelling ...
Breaking Biology Technology: