Navigation Links
NIH funds research to identify Parkinson's biomarkers
Date:2/14/2013

The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), awarded a three-year, $900,000 grant to the Center for Biomedical Imaging Statistics at Emory's Rollins School of Public Health. The grant will fund the center's biomarker research in Parkinson's disease to identify non-invasive imaging measures that can detect changes in brain function and biochemistry.

Led by F. DuBois Bowman, PhD, associate professor and director of the Center for Biomedical Imaging Statistics, the team is one of nine research groups funded by NINDS that supports efforts to develop new technologies and tools for biomarker discovery, and data and sharing across the Parkinson's community. The idea is to create a larger study pool to accurately identify biomarkers (changes in the body or brain that can be used to predict, diagnose) in Parkinson's disease.

Bowman's team will develop new statistical tools that identify multiple biomarkers in the brain by observing differences in neural activity or abnormal alterations in brain function and structure.

"Our primary goal is to achieve a better prognosis for patients by identifying neuro-degeneration earlier," says Bowman. "In doing this, we prompt the development of new treatments, accurately identify who is likely to progress to develop Parkinson's, and develop findings that can be used to set up future clinical trials. There are currently no proven biomarkers for this disease."

Parkinson's disease is a movement disorder that affects nearly 1 million people in the United States. The lack of biomarkers for Parkinson's disease has been a major challenge for developing better treatments. Classic signs of the disease include tremors, stiffness and changes in speech and gait. Inside the brain, there is a progressive loss of cells in a motor-controlled region called the substantia nigra and an accumulation of protein-filled structures called Lewy bodies.

According to Bowman, there are no diagnostic tests that confirm Parkinson's disease. Instead, physicians base Parkinson's diagnoses on a combination of medical history, symptoms, neurological and physical examinations, and response to certain medications. Bowman and his team will develop statistical algorithms that will filter through millions of different possible brain measurements to detect changes that indicate neuro-degeneration related to Parkinson's. This will help accurately distinguish groups that are more likely to develop Parkinson's, thus changing what is known about the disease, enabling diagnosis before the classic motor symptoms occur and potentially altering treatments.

The research project has two aims:

1. Imaging-based Biomarkers: Using imaging technology, the team will capture changes in brain activity, structure and pathology related to Parkinson's. A novel aspect of the research will be combining different types of imaging data as well as other biologic information to extract multidimensional Parkinson's disease biomarkers.

2. Utilization of Comprehensive Clinical Database Through a partnership with Kaiser Permanente of Georgia, the researchers will be able to access comprehensive, non-identifiable, patient medical records. They will compare and contrast medical histories, laboratory test results, medications and additional diagnoses to determine a risk-factor profile for Parkinson's.

All nine research groups funded by the NINDS will have access to each group's work through a web-based management system. The researchers will work together to apply their broad clinical and research expertise and samplings to their own research.

"The core of all of our research in the Parkinson's Disease Biomarker Program is to redefine Parkinson's," explains Bowman. "This program allows an avenue for researchers to unite, collaborate and ultimately expedite the advancement of understanding and treatment of Parkinson's disease."


'/>"/>

Contact: Melva Robertson
melva.robertson@emory.edu
404-727-5692
Emory Health Sciences
Source:Eurekalert

Related biology news :

1. Researchers at GW receive federal funds to study the effect earthquakes have on nuclear reactors
2. NIH funds development of tissue chips to help predict drug safety
3. WaterSMART funds $1.7 million for science projects in desert and southern Rockies LCCs
4. EU FET program funds research on 3D neuronal structures mimicking human brain tissue
5. CIRM funds 6 UC San Diego stem cell researchers
6. NASA funds SAO instrument to track North American air pollution
7. Inspired: Canada funds 68 bold, inventive ways to improve health, save lives in developing countries
8. Energy Deptartment funds UW project to turn wasted natural gas into diesel
9. NIH grant funds Boston College research into illnesses afflicting people living with HIV
10. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
11. Research reveals first evidence of hunting by prehistoric Ohioans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2016)... January 21, 2016 ... new market research report "Emotion Detection and Recognition Market by ... Tools (Facial Expression, Voice Recognition and Others), Services, ... forecast to 2020", published by MarketsandMarkets, the global ... reach USD 22.65 Billion by 2020, at a ...
(Date:1/20/2016)... Jan. 20, 2016  Synaptics Incorporated (NASDAQ: ... solutions, today announced sampling of S1423, its newest ... and small screen applications including smartwatches, fitness trackers, ... round and rectangular shapes, as well as thick ... with moisture on screen, while wearing gloves, and ...
(Date:1/13/2016)... 13, 2016 --> ... new market report titled - Biometric Sensors Market - Global ... - 2023. According to the report, the global biometric sensors market was ... to reach US$1,625.8 mn by 2023, expanding at a ... of volume, the biometric sensors market is expected to ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... Novan, Inc. today announced that Director Robert A. ... of Novan. In addition, Robert Keegan has been appointed ... . --> North Carolina . ... a total of $32.8 million of net proceeds in a private ... originating throughout the Research Triangle area of North Carolina ...
(Date:2/8/2016)... ... 2016 , ... Franz Inc. , an early innovator ... announced the availability of AllegroGraph 6, the leading Semantic Graph Database with certification ... Program (CCPT). AllegroGraph is the first Semantic Graph Database to be certified ...
(Date:2/6/2016)... ... 06, 2016 , ... The Center for Excellence in Education (CEE) will sponsor ... on Wednesday February 10, 2016. This Bite of Science session, hosted by the ... at 1500 Remount Road in Front Royal, VA from 5:00 p.m. to 8:00 p.m. ...
(Date:2/5/2016)... SAN FRANCISCO , February 5, 2016 ... AMBS), a biotechnology company focused on developing products ... it has requested Rare Pediatric Disease Designation (RPDD) from ... retinitis pigmentosa (RP) with MANF. MANF was previously granted ... December 2014. --> Amarantus BioScience Holdings, Inc. ...
Breaking Biology Technology: