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NIH funds new grants exploring use of genome sequencing in patient care
Date:7/23/2013

than one condition and gain insights to whether certain mutations cause milder or more severe cases of some conditions. The scientists plan to provide information on genetic differences to study participants and families and use questionnaires and interviews to better understand the impact of genomic testing results on families.

  • University of Michigan, Ann Arbor, $7.97 million (pending available funds)

    Principal Investigator: Arul Chinnaiyan, M.D., Ph.D.

    Dr. Chinnaiyan and his team will sequence the genomes of tumors from 500 patients with advanced sarcoma or other rare cancers to discover new information about genomic alterations, with the goal of eventually customizing therapies. Few clinical trials have been conducted in most rare cancers, and scientists would like to know more about the genetic underpinnings of these diseases. Investigators also plan to evaluate the patient consent process, and the delivery and use of genome sequencing results.

  • University of Washington, Seattle, $3 million (pending available funds)

    Principal Investigators: Gail Jarvik, M.D., Ph.D., Wylie Burke, M.D., Ph.D., Debbie Nickerson, Ph.D., Peter Tarczy-Hornoch, M.D.

    Dr. Jarvik and her colleagues at the University of Washington will lead the coordinating center responsible for pulling together all of the scientific teams, helping to organize studies, interpreting study results and helping groups focus on common goals. The coordinating center team members bring their own expertise in clinical genetics, genome sequencing, bioinformatics and ethics.

    These awards are supported by NIH grants 1UM1HG006508-01AL, 1UM1HG007292-01, 1UM1HG007301-01, and 1U01HG007307-01.


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  • Contact: Steven Benowitz
    steven.benowitz@nih.gov
    301-451-8325
    NIH/National Human Genome Research Institute
    Source:Eurekalert

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