Date:4/12/2011

in humans. In years three through five, researchers will conduct a Phase I "feasibility and proof of principle" study in which patients with advanced non-small cell lung cancer (the most common type), and who no longer respond to standard therapy, will inhale 5-azacytidine. Albert Einstein College of Medicine has filed a patent application related to this research, which is available for licensing to partners interested in further testing and developing this treatment.

The ultimate aim of the research is to intervene with inhaled 5-azacytidine at an earlier, precancerous stage, when vital genes have been silenced but cancer has not yet developed. Using the therapy in this way it might prevent lung cancer from developing in people with a history of cigarette smoking. According to the Centers for Disease Control and Prevention, there are about 46 million adult smokers in the U.S.

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Contact: Kim Newman sciencenews@einstein.yu.edu 718-430-3101 Albert Einstein College of Medicine Source:Eurekalert

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