Navigation Links
NIH funds investigation of inhaled lung cancer treatment

April 11, 2011 (BRONX, NY) Just as inhaling cigarette smoke can cause lung cancer, inhaling medication may treat it. Two researchers at Albert Einstein College of Medicine of Yeshiva University have received a five-year, $2.4 million grant from the National Institutes of Health to clinically develop an inhaled therapy for lung cancer to be used before the cancer becomes malignant and spreads.

The grant recipients are Roman Perez-Soler, M.D., professor of medicine and associate director of clinical research at Albert Einstein Cancer Center; and Yiyu Zou, Ph.D., associate professor of medicine. Dr. Perez-Soler is also chair of oncology at Montefiore Medical Center.

Lung cancer is the leading cause of cancer mortality among men and women in the U.S. Each year, more than 220,000 are diagnosed and about 150,000 people die from the disease. The average five-year survival rate is only 15 percent, largely because nearly 80 percent of cases are diagnosed after the cancer has spread from the lungs to other organs in the body. Drs. Perez-Soler and Zou will take advantage of the fact that, for many years, the disease is confined to the bronchial epithelium (surface cells of the airways), where it lingers and develops in a premalignant state.

The research project involves inhaling a drug called 5-azacytidine to target the bronchial epithelium. 5-azacytidine is a demethylating agent, meaning it strips off methyl groups that have bound to genes and rendered them inactive. Since removing methyl groups can reactivate genes that suppress tumors, drugs such as 5-azacytidine can potentially treat a number of different types of cancers.

The first two years of the federally-funded study will focus on a mouse model of premalignant lung cancer, to determine what dose is likely to be safe and effective in humans. In years three through five, researchers will conduct a Phase I "feasibility and proof of principle" study in which patients with advanced non-small cell lung cancer (the most common type), and who no longer respond to standard therapy, will inhale 5-azacytidine. Albert Einstein College of Medicine has filed a patent application related to this research, which is available for licensing to partners interested in further testing and developing this treatment.

The ultimate aim of the research is to intervene with inhaled 5-azacytidine at an earlier, precancerous stage, when vital genes have been silenced but cancer has not yet developed. Using the therapy in this way it might prevent lung cancer from developing in people with a history of cigarette smoking. According to the Centers for Disease Control and Prevention, there are about 46 million adult smokers in the U.S.


Contact: Kim Newman
Albert Einstein College of Medicine

Related biology news :

1. Cystic Fibrosis Foundation funds Marshall research
2. NSF funds study of landscape restoration effects on Pennsylvania stream
3. Keck Foundation funds work on tiny, implantable computers to restore lost brain functions
4. FDA funds pediatric trial testing genetically reprogrammed HSV to treat cancer
5. NIH funds Center of Excellence for Molecular Hematology at Cincinnati Childrens
6. $1.5M grant funds research aimed at reducing strokes in children with sickle cell disease
7. NIH funds center at Arizona State to battle infectious diseases
8. French national research agency funds PREDIMOL project
9. NHGRI funds development of third generation DNA sequencing technologies
10. $22.5 million grant funds international study of membrane proteins
11. NSF funds innovative approach to biomimetic nanofiber bone regeneration
Post Your Comments:
(Date:10/29/2015)... Oct. 29, 2015  Rubicon Genomics, Inc., today ... distribution of its DNA library preparation products, including ... new ThruPLEX Plasma-seq kit. ThruPLEX Plasma-seq has been ... of NGS libraries for liquid biopsies--the analysis of ... prognostic applications in cancer and other conditions. Eurofins ...
(Date:10/29/2015)... 29, 2015 Today, LifeBEAM , ... with 2XU, a global leader in technical performance ... hat with advanced bio-sensing technology. The hat will ... monitor key biometrics to improve overall training performance. ... two companies will bring together the most advanced technology, ...
(Date:10/27/2015)... SAN JOSE, Calif. , Oct. 27, 2015 /PRNewswire/ ... human interface solutions, today announced that Google has adopted ... family of touch controller solutions to power its newest ... Nexus 6P by Huawei. --> ... ecosystem partners like Google to provide strategic collaboration in ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... ... , ... Global Stem Cells Group Chile CEO ... America and abroad for the first Iberoamerican Convention on Aesthetic Medicine, Cosmetology and ... will present and discuss new trends in anti-aging stem cell treatments, regenerative medicine ...
(Date:11/30/2015)... ... 30, 2015 , ... Global Stem Cells Group announced the opening of a new ... Arica and Iquique in northern Chile. The facilities are part of GSCG’s expansion efforts in ... and techniques in stem cell medicine to patients from around the world. , The clinics ...
(Date:11/30/2015)... 1, 2015 Partnership includes an ... for the u niversity , s ... treatment s cale - up ... Africa , where licensees based anywhere in the world will ... technology. --> Africa , where licensees based anywhere in the ...
(Date:11/30/2015)... 30, 2015 /PRNewswire/ - Zenith Epigenetics Corp. ("Zenith" or the ... C.W. Wong to its Board of Directors to replace ... with a wealth of experience as co-founder of Resverlogix, with ... --> --> Dr. Wong remarked, ... of directors. Zenith,s long standing expertise in epigenetics and the ...
Breaking Biology Technology: