Navigation Links
NIH funds development of tissue chips to help predict drug safety
Date:7/24/2012

Seventeen National Institutes of Health grants are aimed at creating 3-D chips with living cells and tissues that accurately model the structure and function of human organs such as the lung, liver and heart. Once developed, these tissue chips will be tested with compounds known to be safe or toxic in humans to help identify the most reliable drug safety signals ultimately advancing research to help predict the safety of potential drugs in a faster, more cost-effective way. The initiative marks the first interagency collaboration launched by the NIH's recently created National Center for Advancing Translational Sciences (NCATS).

Tissue chips merge techniques from the computer industry with modern tissue engineering by combing miniature models of living organ tissues on a transparent microchip. Ranging in size from a quarter to a house key, the chips are lined with living cells and contain features designed to replicate the complex biological functions of specific organs.

NIH's newly funded Tissue Chip for Drug Screening initiative is the result of collaborations that focus the resources and ingenuity of the NIH, Defense Advanced Research Projects Agency (DARPA) and U.S. Food and Drug Administration. NIH's Common Fund and National Institute of Neurological Disorders and Stroke led the trans-NIH efforts to establish the program. The NIH plans to commit up to $70 million over five years for the program.

"Serious adverse effects and toxicity are major obstacles in the drug development process," said Thomas R. Insel, M.D., NCATS acting director. "With innovative tools and methodologies, such as those developed by the tissue chip program, we may be able to accelerate the process by which we identify compounds likely to be safe in humans, saving time and money, and ultimately increasing the quality and number of therapies available for patients."

More than 30 percent of promising medications have failed in human clinical trials because they are det
'/>"/>

Contact: NCATS Office of Communications
info@ncats.nih.gov
301-435-0888
National Center for Advancing Translational Sciences
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Researchers at GW receive federal funds to study the effect earthquakes have on nuclear reactors
2. Gladstone scientists identify critical process in stem cell development
3. The genomics symposium to boost the further development of cancer research
4. Oligonucleotide Delivery: Biology, Engineering and Development Conference
5. Environmental estrogens affect early developmental activity in zebrafish
6. Turning down the dial: Ocean energy development with less sound
7. MARC travel awards announced for the Society for Developmental Biology 71st Annual Meeting
8. Development of prosthetic hands stagnated for 20 years
9. New Tool Helps Drug Developers Optimize Their Research and Target Development for Better Results and a Stronger Competitive Edge
10. Navigating the Patent Minefield of Embryonic Stem Cell Product Development; Free Kindle Fire Tablet and Research Database with Purchase
11. Mice with big brains provide insight into brain regeneration and developmental disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... REDWOOD CITY, Calif. , Aug. 6, 2015 ... (D-Silicon Valley) will visit Crossmatch ™ to ... secure networks and protect data. Crossmatch is a ... solutions whose technologies and expertise are helping federal ... operational efficiency and security.   "The ...
(Date:8/5/2015)... 5, 2015 Transparency Market Research ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... facial recognition is forecast to reach US$ 2,671.8 Mn ... for surveillance systems by civil and government agencies. This ... and terrorist activities across the globe that would elevate ...
(Date:8/3/2015)... SAN JOSE, Calif. , Aug. 3, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that members ... investment community at the Pacific Crest Global Technology Leadership ... Mountain Time. The conference will be held at the ... The presentation may include forward-looking information. ...
Breaking Biology News(10 mins):Rep. Honda to Visit Crossmatch in Redwood City 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6
... are increasingly obtaining endangered or threatened plants, often illegally, and ... in the journal Nature by Patrick Shirey and ... University of Notre Dame. According to their research last ... threatened and endangered under the US Endangered Species Act are ...
... Alberta researchers determined that a fossilized dinosaur bone found in ... of dinosaurs ended between 65.5 and 66 million years ago. ... Larry Heaman from the Department of Earth and Atmospheric Sciences, ... 64.8 million years old. That means this particular plant eater ...
... Visionaries in the field of cardiac therapeutics have long looked ... or repaired by using one,s own heart cells. A study ... scientific journal of the American Heart Association, shows that heart ... to rebuild the damaged heart in the laboratory. ...
Cached Biology News:Notre Dame biologists call for regulation of rare plant sales 2Test shows dinosaurs survived mass extinction by 700,000 years 2Stem cells show promise in repairing a child's heart 2
(Date:8/27/2015)... ... August 27, 2015 , ... Capital Edge Consulting , a nationwide consulting ... to announce their ranking as one of the top 5000 companies listed on the ... across the nation. , “It is truly an honor to be recognized as one ...
(Date:8/27/2015)... 27, 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") ... Biohaven Pharmaceutical Holding Company Limited (Biohaven), announced today ... study of BHV-0223, a glutamate modulating agent. Biohaven ... and recently obtained clearance from the U.S. Food ... testing. Portage holds 54% equity interest in Biohaven, ...
(Date:8/27/2015)... MENLO PARK, Calif. , Aug. 27, 2015 /PRNewswire/ ... company in the emerging field of regenerative medicine, today ... two investor conferences in the month of September.  ... Officer, will present at Rodman & Renshaw,s 17th Annual ... 10:25am ET/7:25am PT at the St. Regis Hotel in ...
(Date:8/27/2015)... -- HUYA Bioscience International (HUYA) today announced the sponsorship of ... HTLV-1, held this week at the University of Tokyo ... is to promote research on HTLV-1 and HTLV-1-associated diseases, ... research related to these fields to advance science, the ... to support this prestigious conference," said Mireille Gillings ...
Breaking Biology Technology:Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4
... Sangamo BioSciences, Inc. (Nasdaq: SGMO ) today announced ... year 2011 financial results on Wednesday, February 8, 2012, after ... a conference call at 5:00 p.m. ET, which will be ... conference call, the company will review the financial results and ...
... 1, 2012  Generex Biotechnology Corporation (OTCBB: GNBT.OB) announced ... Inc., has been awarded a Japanese Patent centering ... immunotherapeutic vaccines.  A number of products developed with ... patent helps to secure the novel Antigen Express ...
... The report " Biomarkers Market (Discovery ... & Forecasts (2011   -   2020) " , ... drivers, restraints, and opportunities in North America, Europe, Asia, and ... data tables and in-depth TOC on the   ...
Cached Biology Technology:Sangamo BioSciences Announces Fourth Quarter and Full Year 2011 Conference Call and Webcast 2Generex Announces Patent Award for its Core Vaccine Technologies in Japan 2Generex Announces Patent Award for its Core Vaccine Technologies in Japan 3Generex Announces Patent Award for its Core Vaccine Technologies in Japan 4MarketsandMarkets: Global Biomarkers Market worth $25.79 Billion by 2016 2MarketsandMarkets: Global Biomarkers Market worth $25.79 Billion by 2016 3
... with new technology incorporating the sophisticated ... flexibility, the new Varian NMR System ... available today., ,The Varian NMR System ... and receiver channel, providing pulse sequence ...
...
Homo sapiens inhibin, beta B (activin AB beta polypeptide) Antigen: Recombinant Protein(142~254aa)...
... in your 35mm dish without transferring ... Chamber has separate openings for solution ... fluctuations of the liquid level in ... from entering the chamber. An adjustable ...
Biology Products: