Navigation Links
NIH funds development of tissue chips to help predict drug safety

Seventeen National Institutes of Health grants are aimed at creating 3-D chips with living cells and tissues that accurately model the structure and function of human organs such as the lung, liver and heart. Once developed, these tissue chips will be tested with compounds known to be safe or toxic in humans to help identify the most reliable drug safety signals ultimately advancing research to help predict the safety of potential drugs in a faster, more cost-effective way. The initiative marks the first interagency collaboration launched by the NIH's recently created National Center for Advancing Translational Sciences (NCATS).

Tissue chips merge techniques from the computer industry with modern tissue engineering by combing miniature models of living organ tissues on a transparent microchip. Ranging in size from a quarter to a house key, the chips are lined with living cells and contain features designed to replicate the complex biological functions of specific organs.

NIH's newly funded Tissue Chip for Drug Screening initiative is the result of collaborations that focus the resources and ingenuity of the NIH, Defense Advanced Research Projects Agency (DARPA) and U.S. Food and Drug Administration. NIH's Common Fund and National Institute of Neurological Disorders and Stroke led the trans-NIH efforts to establish the program. The NIH plans to commit up to $70 million over five years for the program.

"Serious adverse effects and toxicity are major obstacles in the drug development process," said Thomas R. Insel, M.D., NCATS acting director. "With innovative tools and methodologies, such as those developed by the tissue chip program, we may be able to accelerate the process by which we identify compounds likely to be safe in humans, saving time and money, and ultimately increasing the quality and number of therapies available for patients."

More than 30 percent of promising medications have failed in human clinical trials because they are determined to be toxic despite promising pre-clinical studies in animal models. Tissue chips, which are a newer human cell-based approach, may enable scientists to predict more accurately how effective a therapeutic candidate would be in clinical studies.

The 17 NIH award recipients are listed below. For more details about each project, please visit

Cincinnati Children's Hospital Medical Center
Generating human intestinal organoids with an enteric nervous system
James M. Wells, Ph.D.

Columbia University Health Sciences, New York City
Modeling complex disease using induced pluripotent stem cell-derived skin constructs
Angela Christiano, Ph.D.

Cornell University, Ithaca, N.Y.
Microphysiological systems and low cost microfluidic platform with analytics
Michael L. Shuler, Ph.D.

Duke University, Durham, N.C.
Circulatory system and integrated muscle tissue for drug and tissue toxicity
George A. Truskey, Ph.D.

Harvard University, Cambridge, Mass.
Human cardio-pulmonary system on a chip
Kevin K. Parker, Ph.D.

Johns Hopkins University, Baltimore
Human intestinal organoids: Pre-clinical models of non-inflammatory diarrhea
Mark Donowitz, M.D.

Johns Hopkins University, Baltimore
A 3-D model of human brain development for studying gene/environment interactions
Thomas Hartung, M.D., Ph.D.

Massachusetts Institute of Technology (MIT), Cambridge
All-human microphysical model of metastasis and therapy
Linda Griffith, Ph.D.

Morgridge Institute for Research at the University of WisconsinMadison
Human induced pluripotent stem cell and embryonic stem cell-based models for predictive neural toxicity and teratogenicity
James A. Thomson, V.M.D., Ph.D.

University of California, Berkeley
Disease-specific integrated microphysiological human tissue models
Kevin E. Healy, Ph.D.

University of California, Irvine
An integrated in vitro model of perfused tumor and cardiac tissue
Steven C. George, M.D., Ph.D.

University of Pennsylvania, Philadelphia
Modeling oxidative stress and DNA damage using a gastrointestinal organotypic culture system
John P. Lynch, M.D., Ph.D.

University of Pittsburgh
A 3-D biomimetic liver sinusoid construct for predicting physiology and toxicity
D. Lansing Taylor, Ph.D.

University of Pittsburgh
Three-dimensional osteochondral micro-tissue to model pathogenesis of osteoarthritis
Rocky S. Tuan, Ph.D.

The University of Texas Medical Branch at Galveston
Three-dimensional human lung model to study lung disease and formation of fibrosis
Joan E. Nichols, Ph.D.

University of Washington, Seattle
A tissue-engineered human kidney microphysiological system
Jonathan Himmelfarb, M.D.

Vanderbilt University, Nashville
Neurovascular unit on a chip: Chemical communication, drug and toxin responses
John P. Wikswo, Ph.D.

In fiscal year 2012, NCATS contributed about $9 million to these awards. The NIH Common Fund provided $4 million.

"The tissue chip program aims to improve drug development for a multitude of different diseases, and will also provide fundamental knowledge about biology that is relevant to multiple scientific disciplines," said James M. Anderson, M.D., Ph.D., director of the Division of Program Coordination, Planning, and Strategic Initiatives that guides the NIH Common Fund's programs. "The transformative potential of this program, along with its interdisciplinary nature, make this an excellent example of the type of high-impact research supported by the Common Fund."

The NIH and DARPA programs will be coordinated closely. For example, DARPA has entered into cooperative agreements with two of the NIH recipients, the Wyss Institute at Harvard University and MIT, to develop engineering platforms capable of integrating 10 or more organ systems. The FDA will help explore how this new technology might be utilized to assess drug safety, prior to approval for first-in-human studies.

In total, 15 NIH institutes and centers are assisting in the coordination of this program. For a complete list visit (URL to come).

Contact: NCATS Office of Communications
National Center for Advancing Translational Sciences

Related biology news :

1. Researchers at GW receive federal funds to study the effect earthquakes have on nuclear reactors
2. Gladstone scientists identify critical process in stem cell development
3. The genomics symposium to boost the further development of cancer research
4. Oligonucleotide Delivery: Biology, Engineering and Development Conference
5. Environmental estrogens affect early developmental activity in zebrafish
6. Turning down the dial: Ocean energy development with less sound
7. MARC travel awards announced for the Society for Developmental Biology 71st Annual Meeting
8. Development of prosthetic hands stagnated for 20 years
9. New Tool Helps Drug Developers Optimize Their Research and Target Development for Better Results and a Stronger Competitive Edge
10. Navigating the Patent Minefield of Embryonic Stem Cell Product Development; Free Kindle Fire Tablet and Research Database with Purchase
11. Mice with big brains provide insight into brain regeneration and developmental disorders
Post Your Comments:
(Date:5/16/2017)... --  Bridge Patient Portal , an enterprise patient ... Systems , an electronic medical record solutions developer ... a partnership to build an interface between the ... products, including Centricity Practice Solution (CPS), Centricity Business ... integrations will allow healthcare delivery networks using GE ...
(Date:4/19/2017)... ALBANY, New York , April 19, 2017 /PRNewswire/ ... highly competitive, as its vendor landscape is marked by ... in the market is however held by five major ... and Safran. Together these companies accounted for nearly 61% ... majority of the leading companies in the global military ...
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... Customers often ... control technology again and again. METTLER TOLEDO has released two new videos that ... illustrate how integration of the ACT350 into Siemens and Allen Bradley PLCs is ...
(Date:5/22/2017)... ... 2017 , ... Baltimore biotech firm, PathSensors, announced that its ... developing and issuing recommendations to grow Maryland's biohealth industry and position the state ... , The recommendations are contained in a report from the Maryland ...
(Date:5/21/2017)... ... May 19, 2017 , ... Ovation Fertility scientists’ ... American Association of Bioanalysts (AAB) and the College of Reproductive Biology (CRB) today ... AAB’s commitment to excellence in clinical laboratory services and regulations. , “We ...
(Date:5/19/2017)... (PRWEB) , ... May 19, 2017 , ... In response ... treating gait disorders, Biodex Medical Systems, Inc. announces the release of their Gait Trainer ... has been joined with a biomedical system to aid in rehabilitating individuals with cerebral ...
Breaking Biology Technology: