Navigation Links
NIH funds development of resistance-breaking insecticides to reduce malaria transmission
Date:4/12/2009

been realized," said Carlier.

However, the team made two important advances which form the basis for the NIAID grant for "Development of vector-specific, resistance breaking insecticides to reduce malaria transmission."

"First, we discovered we could modify the chemical structures of existing AChE-targeting insecticides in a way that should significantly lower their toxicity to mammals," said Carlier. Since these compounds still retain significant insecticidal activity against the malaria mosquito, they could prove ideal for deployment on ITNs. Two patent applications have been filed and commercial interest has been expressed in the potentially safer compounds, he said.

"Second, we figured out how to inhibit target site-resistant mosquito AChE and demonstrated this effect in vitro," said Carlier. "The challenge now is to modify these inhibitors so that they can make their way into the mosquito's brain and thus exert the desired insecticidal action."

The new insecticides should also be less likely to cause the emergence of new target site-resistant strains, he said. And the team has developed a number of other strategies to ward against metabolic resistance mechanisms in the Anopheles gambiae mosquito.

In addition to principal investigator Carlier and co-investigator Bloomquist, other co-investigators on the NIAID-funded research team are Jianyong Li, associate professor of biochemistry in the College of Agriculture and Life Sciences at Virginia Tech, and Maxim Totrov, principal scientist at Molsoft LLC of La Jolla, Calif.

Carlier is responsible for the design of synthetic routes to the AChE-based insecticides. Bloomquist is responsible for the pharmacological and toxicological assessment of the proposed insecticides. Li, who has extensive experience in isolating and crystallizing a number of important mosquito enzymes in native form, is responsible for expressing, purifying, and crystallizing various Anophele
'/>"/>

Contact: Susan Trulove
STrulove@vt.edu
540-231-5646
Virginia Tech
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. NIH funds research center for womens reproductive health at Einstein
2. Autism Speaks funds $5 million to studies on genetic and environmental risk factors for autism
3. F-MARC funds more soccer and health research
4. More freedom to take risks: DFG funds the first Reinhart Koselleck Projects
5. NIH funds 16 Science Education Partnership Awards
6. NSF funds research at Illinois on sustainable biofuels infrastructure
7. NIAID funds studies of how SARS and bird flu evade antiviral responses
8. Human Microbiome Project awards funds for technology development, data analysis and ethical research
9. NSF funds new Center for the Physics of Living Cells at Illinois
10. NSF funds multi-university center to study environmental implications of nanotechnology
11. NIH EUREKA award funds research at WPI aimed at turning adult skin cells into stem-like cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015  A man-made form of insulin delivered by nasal ... in adults with mild cognitive impairment and Alzheimer,s disease ... at Wake Forest Baptist Medical Center. The ... cognitive impairment (MCI) or mild to moderate Alzheimer,s dementia ...
(Date:1/22/2015)... Issued by Small Cap IR. In 2011, Nilson Report,s annual ... merchants on the leading payment cards rose to $135.3 billion ... prepaid cards reached 6.54 billion.  Eight million credit card users ... 2012, and credit and debit card fraud resulted in $11.27 ...
(Date:1/22/2015)... 2015   EyeLock, Inc. , a market leader of iris-based ... Gerber to the new role of Senior Vice President ... development of mobile platforms and wearable solutions for EyeLock,s technologies. ... in the semiconductor industry to his role at EyeLock, with ...
Breaking Biology News(10 mins):Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2
... great number of women experience depression or anxiety while ... mood disorders may lead to long-term emotional and behavioral ... the fetal environment has a strong influence on offspring ... exact mechanisms by which this occurs are not completely ...
... turns out that your messenger RNA may catch more than one ... mRNA may travel one way down a cell, then board another, ... get where it ultimately needs to be. It,s a ... differentiating a brain cell from, say, a muscle cell, said ...
... genetic material in our cells are iconically depicted as ... cell is about to divide and the entire contents of ... to get a good picture of the way that our ... is neatly bundled into the nucleus while enabling day-to-day (non-dividing) ...
Cached Biology News:2-way traffic enable proteins to get where needed, avoid disease 2Chromosomes show off their shapes 2
(Date:1/22/2015)... 22, 2015 GEA Niro Soavi the ... laboratory homogenizer, the PandaPLUS 2000, which is ideal for ... and cell disruption . This compact laboratory homogenizer ... juices, liquid food, food additives and ingredients as well ...
(Date:1/22/2015)... CAMBRIDGE, Mass (PRWEB) January 21, 2015 Cambridge ... Semantic Web technology, today announced that 2014 was a record-breaking ... expanding the capabilities of the Anzo Smart Data Platform and ... discover and utilize insights from diverse data which led to ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting ... brand-neutral, independent consultants, Protocol Networks has recently announced its ... the years, his company has attracted several clients in ... as well as others. With the success of these ...
(Date:1/22/2015)... California (PRWEB) January 22, 2015 Pipette.com ... Offer to their comprehensive portfolio of Eppendorf products. ... customers to purchase a Centrifuge 5424/5424 R and receive ... of either Eppendorf Research plus or Eppendorf Reference 2 ...
Breaking Biology Technology:GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Cambridge Semantics Announces Record Results for 2014 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2
... CHENGDU, China , June 3 /PRNewswire-Asia-FirstCall/ -- Tianyin,Pharmaceutical Co., Inc. (NYSE ... the updated corporate presentation at the Company,s website: , , ... http://www.tianyinpharma.com , , , ... , , ...
... June 2 Caliper Life Sciences, Inc. (Nasdaq: CALP ... Sciences Conference, will be webcast on Friday, June 11 at ... will be providing an update on the company,s business. The live webcast ... available for 90 days. , , ...
... Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced today that Kevin ... at the Jefferies 2010 Global Life Sciences Conference and also at the 9th ... , , ... place on Wednesday, June 9, 2010 at 1:30 p.m. Eastern ...
Cached Biology Technology:Tianyin Corporate Presentation Updated 2Neurocrine Biosciences to Present at the Jefferies 2010 Global Life Sciences Conference and the 9th Annual Needham Healthcare Conference 2
GOAT ANTI HUMAN PARAINFLUENZA VIRUS 2+3...
75 x 25 mm; sterile, recommended for immunohistochemistry of cell lines growing in suspension, Poly-D-Lysine coated, glass slides with polystyrene vessel, lid and safety removal tool...
ANTI 5-HYDROXYTRYPTOPHAN CONJ....
IMAGEQUANT 300 WKSTN, 1 EA. Category: ImageQuant CCD Imagers....
Biology Products: