Navigation Links
NIH funds development of resistance-breaking insecticides to reduce malaria transmission
Date:4/12/2009

been realized," said Carlier.

However, the team made two important advances which form the basis for the NIAID grant for "Development of vector-specific, resistance breaking insecticides to reduce malaria transmission."

"First, we discovered we could modify the chemical structures of existing AChE-targeting insecticides in a way that should significantly lower their toxicity to mammals," said Carlier. Since these compounds still retain significant insecticidal activity against the malaria mosquito, they could prove ideal for deployment on ITNs. Two patent applications have been filed and commercial interest has been expressed in the potentially safer compounds, he said.

"Second, we figured out how to inhibit target site-resistant mosquito AChE and demonstrated this effect in vitro," said Carlier. "The challenge now is to modify these inhibitors so that they can make their way into the mosquito's brain and thus exert the desired insecticidal action."

The new insecticides should also be less likely to cause the emergence of new target site-resistant strains, he said. And the team has developed a number of other strategies to ward against metabolic resistance mechanisms in the Anopheles gambiae mosquito.

In addition to principal investigator Carlier and co-investigator Bloomquist, other co-investigators on the NIAID-funded research team are Jianyong Li, associate professor of biochemistry in the College of Agriculture and Life Sciences at Virginia Tech, and Maxim Totrov, principal scientist at Molsoft LLC of La Jolla, Calif.

Carlier is responsible for the design of synthetic routes to the AChE-based insecticides. Bloomquist is responsible for the pharmacological and toxicological assessment of the proposed insecticides. Li, who has extensive experience in isolating and crystallizing a number of important mosquito enzymes in native form, is responsible for expressing, purifying, and crystallizing various Anophele
'/>"/>

Contact: Susan Trulove
STrulove@vt.edu
540-231-5646
Virginia Tech
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. NIH funds research center for womens reproductive health at Einstein
2. Autism Speaks funds $5 million to studies on genetic and environmental risk factors for autism
3. F-MARC funds more soccer and health research
4. More freedom to take risks: DFG funds the first Reinhart Koselleck Projects
5. NIH funds 16 Science Education Partnership Awards
6. NSF funds research at Illinois on sustainable biofuels infrastructure
7. NIAID funds studies of how SARS and bird flu evade antiviral responses
8. Human Microbiome Project awards funds for technology development, data analysis and ethical research
9. NSF funds new Center for the Physics of Living Cells at Illinois
10. NSF funds multi-university center to study environmental implications of nanotechnology
11. NIH EUREKA award funds research at WPI aimed at turning adult skin cells into stem-like cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... "molecular brakes" that time the generation of important cells ... cells" translate sound waves into electrical signals that are ... If the arrangement of the cells is disordered, hearing ... will be published in The Journal of Neuroscience ... Hey2 act as brakes to prevent hair cell generation ...
(Date:9/16/2014)... make us sick can take up residence in and ... or other troublesome symptom, according to new research at ... , On average, healthy individuals carry about five types ... in BioMed Central Biology . The study is ... viruses in healthy people. , The research was ...
(Date:9/16/2014)... chunk of rock hit the Yukatan peninsula near the site ... 100 teratons of TNT. It left a crater more than ... and volcanism are widely accepted to have wiped out the ... But what happened to the plants on which the dinosaurs ... University of Arizona reveals that the meteorite impact that spelled ...
Breaking Biology News(10 mins):Hey1 and Hey2 ensure inner ear 'hair cells' are made at the right time, in the right place 2Healthy humans make nice homes for viruses 2Healthy humans make nice homes for viruses 3Meteorite that doomed the dinosaurs helped the forests bloom 2Meteorite that doomed the dinosaurs helped the forests bloom 3
... - Primary Energy Recycling Corporation (TSX: PRI), (the "Company") a clean energy company ... announced its financial and operational results for the first quarter ended March ... Highlights for the ... 4.3% for the three months ended March 31, 2010, ...
... Spain and the UK have identified the final piece in ... Published today by PNAS, the breakthrough discovery by the Consejo ... of East Anglia (UEA) has implications for agribusiness, the environment ... deposit which accumulates in the seeds, beans and tubers of ...
... cystic fibrosis can be caused by genetic "nonsense mutations" ... Bedwell, Ph.D., a professor in the University of Alabama ... now closer to producing drugs that will fix this ... Bedwell is a renowned researcher on the select group ...
Cached Biology News:Primary Energy Reports Improved First Quarter Results 2Primary Energy Reports Improved First Quarter Results 3Primary Energy Reports Improved First Quarter Results 4Primary Energy Reports Improved First Quarter Results 5Scientists discover final piece in phytate jigsaw 2Drug may treat cystic fibrosis, other diseases caused by 'nonsense mutations,' UAB researcher says 2
(Date:9/16/2014)... From cell phones to cars and flashlights, ... Scientists and technology companies constantly are seeking ways ... the first time using a water-based solution, researchers ... long-lasting and more efficient nuclear battery that could ... reliable energy source in automobiles and also in ...
(Date:9/16/2014)... CHAPEL HILL, N.C. , Sept. 16, 2014 /PRNewswire/ ... its experimental heart failure compound has been shown to ... The preclinical results demonstrate an alternative to intravenous infusions ... with HNO prodrugs. The data were presented yesterday at ... Annual Scientific Meeting in Las Vegas ...
(Date:9/16/2014)... , Sept. 16, 2014  The Council ... entrepreneurial support organization in the country, today released ... Report . It showed that ... North Carolina startups in the technology, ... more global investment from a variety of sources. Significant ...
(Date:9/16/2014)... Convoy Therapeutics, Inc., a specialty ... to treat patients directly at the site of ... Technology Platform announced today that John Muraski, Ph.D., ... the White Hat Life Science Investor Conferenceā„¢ on ... In addition, interested individuals can meet Convoy ...
Breaking Biology Technology:Cardioxyl Presents Oral Heart Failure Treatment Data For Its Experimental HNO Prodrug At HFSA 18th Annual Scientific Meeting 2CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 2CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 3CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 4Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 2Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 3
... To highlight its 20 years of experience as ... ( www.microtestlabs.com ) is offering free microbial identification ... tests, to eligible attendees visiting the Microtest exhibit, #828, ... highlight Microtest,s wide range of laboratory testing and validation ...
... RGEN ) announced today that the Company ... will present at the BIO CEO and Investor Conference ... at the Waldorf-Astoria Hotel, 301 Park Avenue, New York, ... available via Repligen,s website at www.repligen.com and ...
... Secretropin(R) , the first clinically proven natural stimulator of ... as a more desirable "first step" approach to pursuing ... Secretropin(R) is only available through ... to increase the body,s own production and release of ...
Cached Biology Technology:Microtest Labs Offers Free Microbial Identification Testing, Free Shipping on Other Tests, to MD&M West Attendees 2Repligen to Present at the BIO CEO & Investor Conference Monday, February 9th, 11:30 a.m. EST 2Secretropin(R) - Effective, Preferable, Affordable as an Alternative to Injectable Growth Hormone - Gains Momentum 2