Navigation Links
NIH funds $9.5 million for research on HIV and the human innate immune system
Date:6/15/2009

h Weinberg and his colleagues discovered that human beta defensins (hBDs), frontline innate defense molecules found in epithelial cells linings in the mouth, inhibit infections from HIV. How this happens in the mouth may explain the protection seen in the mouth against the virus when compared to other body sites.

FOUR RESEARCH PROJECTS

Through four research projects funded by the grant, researchers will examine changes in the frontline defense humans have against infections, such as hBDs and other innate immune molecules, found in the epithelial linings of the mouth, skin and urogenital track, which are constantly challenged by bacteria, fungi and viruses.

In two projects, researchers will design, produce and share altered forms of beta defensins. These altered hBDs will be used to study molecular interactions between beta defensins and key receptors on human cells that the research group had previously identified as important for bolstering innate defenses.

In the third and fourth projects, researchers will identify altered proteins in human epithelial cells from HIV-infected individuals on HAART, compare tissue samples from warts associated with HIV-positive (on HAART) and normal individuals, and find genetic differences between individuals, to explain why some people produce more hBDs than others that could better protect individuals from infections, such as HPV.

According to Weinberg, the projects are highly focused and collaborative and tap the expertise of researchers in innate immunity, defensin biology, structural chemistry, HIV immunology, dermatology, oral medicine and genetics.

Along with Weinberg, project leaders will be School of Medicine's Scott Sieg, Department of Medicine, and Tom McCormick, Department of Dermatology, and the School of Dental Medicine's Richard Jurevic, Department of Biological Sciences.

Weinberg and colleagues will identify changes in innate defense mechanis
'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. NIH funds work at WPI on regenerating heart tissue and preventing urinary tract infections
2. Obama Budget Level Funds Career Technical Education
3. DOE funds bio-inspired solar fuel center at Arizona State
4. G. Unger Vetlesen Foundation funds purchase of state-of-the-art equipment for UMs Rosenstiel School
5. Research team wins funds to unravel a DNA mystery
6. NIH funds development of resistance-breaking insecticides to reduce malaria transmission
7. NIH funds research center for womens reproductive health at Einstein
8. Autism Speaks funds $5 million to studies on genetic and environmental risk factors for autism
9. F-MARC funds more soccer and health research
10. More freedom to take risks: DFG funds the first Reinhart Koselleck Projects
11. NIH funds 16 Science Education Partnership Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... discovery of two additional coral communities showing signs of damage ... of the 2010 spill in the Gulf of Mexico. The ... professor of biology at Penn State University. A paper describing ... in the Gulf of Mexico will be published during the ... of the journal Proceedings of the National Academy of ...
(Date:7/28/2014)... Amundsen reached the South Pole in 1911, but new ... any human. , Using data from 16 ice cores ... including the South Pole, a group led by Joe ... Nevada, created the most accurate and precise reconstruction to ... new record, described in an article published today in ...
(Date:7/28/2014)... An international team of researchers led by the University ... rice. , The genetic information will enhance scientists, and ... as well as enable the development of new rice ... environmental stressors to help solve global hunger challenges. , ... Oryza glaberrima ) and evidence for independent domestication," was ...
Breaking Biology News(10 mins):Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3Generating a genome to feed the world: UA-led team sequences African rice 2Generating a genome to feed the world: UA-led team sequences African rice 3Generating a genome to feed the world: UA-led team sequences African rice 4
... research suggests a higher-protein, lower-carbohydrate energy-restricted diet has a ... and increasing lean muscle, particularly when the proteins come ... September issue of the Journal of Nutrition, ... healthy, premenopausal women. Each consumed either low, medium ...
... wastewater recycling processes may generate more greenhouse gases than ... reasons to continue keep wastewater recycling among the water-resource ... of a new paper by Amy Townsend-Small, assistant professor ... and a team of researchers from the University of ...
... whizzes at learning a second language, but that ability begins ... at the University of Washington,s Institute for Learning & Brain ... prowess at learning languages, with the hope that the findings ... study, the researchers report that the brains of babies raised ...
Cached Biology News:Foods rich in protein, dairy products help dieters preserve muscle and lose belly fat: study 2Wastewater recycling can multiply greenhouse gas emissions 2Wastewater recycling can multiply greenhouse gas emissions 3Bilingual babies' vocabulary linked to early brain differentiation 2Bilingual babies' vocabulary linked to early brain differentiation 3
(Date:7/28/2014)...   JOLT , a leading technology accelerator, announced today ... portfolio of startups. Next-level tech and boundary-pushing innovation have ... accelerator, and Cohort four is no exception, with six ... its launch in July 2012, JOLT has produced 17 ... at 23 investments, JOLT,s portfolio has an overall mix ...
(Date:7/28/2014)... MA (PRWEB) July 28, 2014 Immunomic ... two researchers to further develop potential treatments for glioblastoma ... tumor, in combination with their patented vaccine platform, LAMP-vax. ... Duke University, are based on the work of John ... Neurosurgery at The Preston Robert Tisch Brain Tumor Center ...
(Date:7/28/2014)... It’s a hard truth: Nearly half of recent ... post-secondary education are failing to obtain a diploma or certificate ... according to an analysis by The Resume Place , ... choice of college majors, which leads to underemployment, unemployment or ... 51.7 percent of post-9/11 veterans using GI Bill ...
(Date:7/28/2014)... COLLEGE STATION, Texas , July 28, 2014   ... will be a 177-key, 4-star boutique hotel in the heart of ... , Texas.  Photo - http://photos.prnewswire.com/prnh/20140725/130455 ... first hotel within ATLAS , The ... of standard rooms and suites, a sleek restaurant and bar, a ...
Breaking Biology Technology:JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 2JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 4Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 2Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 4Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 3Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 4
... Veracyte, Inc ., a molecular diagnostics company pioneering the ... of Mark Spring as chief financial officer. ... the Veracyte team," said Bonnie Anderson, Veracyte,s cofounder and ... and senior finance leader in both public and private ...
... Calif., Jan. 26, 2012 Cepheid (Nasdaq: CPHD ... of $80.1 million.  Net loss was $1.6 million, or $(0.03) ... net income of $1.3 million, or $0.02 per diluted share, ... quarter net loss reflected a one-time, non-cash charge to cost ...
... Lend Lease is pleased to announce the appointment of ... Sciences group in the Atlantic Region.  Tom rejoined Lend ... of the Raleigh, NC office, working closely with the regional ... Atlantic offices. He will report directly to Steve Eberling, ...
Cached Biology Technology:Veracyte Appoints Mark Spring as Chief Financial Officer 2Veracyte Appoints Mark Spring as Chief Financial Officer 3Cepheid Reports Fourth Quarter and Full Year 2011 Results 2Cepheid Reports Fourth Quarter and Full Year 2011 Results 3Cepheid Reports Fourth Quarter and Full Year 2011 Results 4Cepheid Reports Fourth Quarter and Full Year 2011 Results 5Cepheid Reports Fourth Quarter and Full Year 2011 Results 6Cepheid Reports Fourth Quarter and Full Year 2011 Results 7Cepheid Reports Fourth Quarter and Full Year 2011 Results 8Cepheid Reports Fourth Quarter and Full Year 2011 Results 9Cepheid Reports Fourth Quarter and Full Year 2011 Results 10Cepheid Reports Fourth Quarter and Full Year 2011 Results 11Lend Lease Announces the Appointment of Tom Chapman as Director Operations for the Life Sciences Group in the Atlantic Region 2
... PCRx Enhancer System is ... polymerases to optimize PCR of ... 10X PCRX Enhancer Solution with ... higher primer specificity broader magnesium ...
6-carboxy-2',4,4',5',7,7'-hexachlorofluorescein, succinimidyl ester (6-HEX, SE) *single isomer*...
Mouse Exodus 2 - 12kDa...
Fibulin-2 (D-15)...
Biology Products: