Navigation Links
NIH-funded researchers show possible trigger for MS nerve damage
Date:11/27/2012

High-resolution real-time images show in mice how nerves may be damaged during the earliest stages of multiple sclerosis. The results suggest that the critical step happens when fibrinogen, a blood-clotting protein, leaks into the central nervous system and activates immune cells called microglia.

"We have shown that fibrinogen is the trigger," said Katerina Akassoglou, Ph.D., an associate investigator at the Gladstone Institute for Neurological Disease and professor of neurology at the University of California, San Francisco, and senior author of the paper published online in Nature Communications.

Multiple sclerosis, or MS, is thought to be an autoimmune disease in which cells that normally protect the body against infections attack nerve cells in the brain and spinal cord, often leading to problems with vision, muscle strength, balance and coordination, thinking and memory. Typically during MS, the immune cells destroy myelin, a protective sheath surrounding nerves, and eventually leading to nerve damage. The immune attack also causes leaks in the blood-brain barrier, which normally separates the brain from potentially harmful substances in the blood.

"Dr. Akassoglou has focused on the role of the blood-brain barrier leak in MS and has discovered that leakage of the blood clotting protein fibrinogen can trigger brain inflammation," said Ursula Utz, Ph.D., M.B.A., a program director at NIH's National Institute of Neurological Disorders and Stroke (NINDS).

Microglia are cells traditionally thought to control immunity in the nervous system. Previous studies suggested that leakage of fibrinogen activates microglia. In this study, Dr. Akassoglou and her colleagues used a cutting-edge imaging technique called two-photon laser scanning microscopy to watch what happens in an animal model of MS.

"Our results provide the first evidence linking leakage of fibrinogen to neuronal damage," said Dr. Akassoglou, "V
'/>"/>

Contact: Christopher Thomas
NINDSPressTeam@ninds.nih.gov
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert  

Page: 1 2

Related biology news :

1. NIH-funded genetic sequencing tool speeds drug discovery, disease diagnostics
2. NIH-funded researchers restore sense of smell in mice using genetic technique
3. NIH-funded study examines use of mobile technology to improve diet and physical activity behavior
4. Temple-Penn researchers identify calcium accelerator to keep cell power supply going
5. Researchers detail the migrations of the wood wasp Sirex noctilio
6. Researchers identify a simple way to precipitate phosphorus from the wastewater of a pulp mill
7. Researchers decode birch tree genome sequence for the first time
8. Researchers develop guidebook for promoting healthy lifestyles among Hispanic populations
9. Researchers study links between conflict and fisheries in East Africa
10. A class of RNA molecules protects germ cells from damage, Penn vet researchers show
11. Researchers sequence swine genome, discover associations that may advance animal and human health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIH-funded researchers show possible trigger for MS nerve damage
(Date:4/17/2014)... deforestation and fragmentation of forests in the Amazon ... forests, contributing to rapid and widespread forest loss ... researchers., The findings show that forests in the ... droughts coupled with forest fires lead to large-scale ... Jennifer Balch, assistant professor of geography, Penn State. ...
(Date:4/17/2014)... new early-warning signs of the potential loss of sight ... for the diagnosis and treatment of diabetic retinopathy, potentially ... "We had not expected to see such striking changes ... Elsner, professor and associate dean in the IU School ... set out to study the early signs, in volunteer ...
(Date:4/17/2014)... the Australian National University (ANU), have developed a ... temperature variability over the past 5.3 million years., ... climate surrounding ice ages over the past two ... between carbon dioxide levels, global temperatures and sea ... Southampton (UoS) and the National Oceanography Centre (NOC) ...
Breaking Biology News(10 mins):Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3Ancient sea-levels give new clues on ice ages 2
... new eco-friendly way of dissolving wood using ionic liquids ... as bio fuels, textiles, clothes and paper. Dr ... School of Chemistry and Chemical Engineering worked along with ... with a more cost and energy efficient way of ...
... recent rapid growth of institutional Memberships for open ... introduction of the "Online Reporting System" for its ... on BioMed Central,s cutting edge publishing platform, the ... budgeting and help reduce the administrative costs associated ...
... presentation, “New Strategies for Optimizing CHO Performance,” to ... called ZAP-CHO during BIO 2009 International Convention in ... 2009 / b3c newswire / – InVitria’s ... present the performance enhancing features of ZAP-CHO, a ...
Cached Biology News:Queen's scientists discover eco-friendly wood dissolution 2InVitria to Unveil Powerful Cell Culture Media Component ZAP-CHO 2
(Date:1/15/2014)... 2014 Look inside the new Preferred ... the lab, from fluid handling to instruments to supplies. ... when you order. , Preferred Solutions features a ... the L/S® model for precise flow control and dispensing ...
(Date:1/15/2014)... Canada (PRWEB) January 15, 2014 This ... on nonclinical and clinical safety assessment in biosimilars. , ... path for biosimilar drug development, however the complex nature ... to quality, safety and efficacy extremely challenging. Based on ...
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... Toronto, ON (PRWEB) January 15, 2014 ... an experimental new therapy for the treatment of tinnitus. ... unique tinnitus frequency, and over a period of weeks to ... Notched Sound Therapy in two forms: Notched Music and Notched ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3
... Inc. (Amex: ADL ), today announced the promotion ... (COO) and CFO. The Company is also,expanding its management ... of International Marketing and Sales and Mr. Raymond Gatchalian ... and CFO, Mr. Ariura will lead the day-to-day operations ...
... SNDY) is pleased to announce that the Company has ... St. Mary,s,Hospital in Waterbury, CT. St. Mary,s has been ... it has chosen to continue using the,Company,s surgical products., ... in the history of Greater,Waterbury, providing nearly a century ...
... CHICAGO, Nov. 6 Advanced Life Sciences,Holdings, Inc. ... in the,discovery, development and commercialization of novel drugs ... diseases, today,announced its financial results for the third ... ), The net loss available to common ...
Cached Biology Technology:AMDL, Inc. Promotes CFO Akio Ariura to Chief Operating Officer and Expands Management Team 2AMDL, Inc. Promotes CFO Akio Ariura to Chief Operating Officer and Expands Management Team 3AMDL, Inc. Promotes CFO Akio Ariura to Chief Operating Officer and Expands Management Team 4Solos Endoscopy, Inc. Receives Purchase Order from Connecticut Hospital 2Advanced Life Sciences Announces Third Quarter 2008 Financial Results 2Advanced Life Sciences Announces Third Quarter 2008 Financial Results 3Advanced Life Sciences Announces Third Quarter 2008 Financial Results 4Advanced Life Sciences Announces Third Quarter 2008 Financial Results 5Advanced Life Sciences Announces Third Quarter 2008 Financial Results 6Advanced Life Sciences Announces Third Quarter 2008 Financial Results 7Advanced Life Sciences Announces Third Quarter 2008 Financial Results 8Advanced Life Sciences Announces Third Quarter 2008 Financial Results 9Advanced Life Sciences Announces Third Quarter 2008 Financial Results 10Advanced Life Sciences Announces Third Quarter 2008 Financial Results 11
Chicken polyclonal to ADI1 ( Abpromise for all tested applications). Antigen: Full length native protein (purified), corresponding to amino acids 1-179 of Human ADI1. Entrez GeneID: 55256 ...
anti-JNK2 Immunogen: Recombinant human JNK2 protein Accession Number: NM_002752 Quality Assurance: Routinely evaluated by immunoblot. Molecular Weight: 46 and/or 54 kDa Available ...
Gloves are 9.25 long, latex, powder free, smooth and ambidextrous....
Request Info...
Biology Products: