Navigation Links
NIH-funded researchers restore sense of smell in mice using genetic technique
Date:9/2/2012

e University of Michigan, Ann Arbor, and Jeremy C. McIntyre, Ph.D., a post-doctoral fellow in Martens' laboratory, worked with a mouse model carrying a mutation in the IFT88 gene. The mutation causes a decrease in the IFT88 protein, which leads to a dramatic reduction in cilia function in several different organ systems, including the olfactory system.

The researchers used an adenovirus to introduce a healthy copy of the gene as a way to restore IFT88 protein levels in the mice. They wanted to see if the reintroduction of the lost protein could restore cilia to the olfactory sensory neurons and return the ability to smell. For three consecutive days, the mice received intranasal gene delivery therapy and then were allowed 10 days for the infected sensory neurons to express the viral-encoded IFT88 protein. After that time, the mice were tested with increasing concentrations of an odorant (amyl acetate). Their responses were measured at the cellular, tissue, and synaptic levels, which all indicated that the mice had regained olfactory function.

"By restoring the protein back into the olfactory neurons, we could give the cell the ability to regrow and extend cilia off the dendrite knob, which is what the olfactory neuron needs to detect odorants," said McIntyre.

The change in olfactory function also has implications in the feeding behavior of the mice. The mouse model the scientists used is born underweight and its anosmia interferes with the motivation to eat, which in many mammals, including humans, is driven by smell. Treatment with adenovirus therapy increased bodyweight by 60 percent in treated compared to untreated mice, indicating that the restored olfactory function was motivating feeding.

The researchers plan to continue their work by developing another mouse model to look at the impact on olfactory function and the potential for restoring function when the IFT88 gene is completely missing, rather than just mutate
'/>"/>

Contact: Robin Latham
lathamr@nidcd.nih.gov
301-496-7243
NIH/National Institute on Deafness and Other Communication Disorders
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. NIH-funded study examines use of mobile technology to improve diet and physical activity behavior
2. UCLA researchers discover missing link between stem cells and immune system
3. Researchers develop new, less expensive nanolithography technique
4. BUSM researchers find potential key to halt progression, reverse damage from emphysema
5. Researchers launch new Rust-Tracker to monitor deadly wheat fungus in 27 nations
6. University of Tennessee Space Institute researchers make clinical trials a virtual reality
7. New equipment is breath of fresh air for childrens lung researchers
8. Mount Sinai researchers solve mystery surrounding the death of two sisters nearly 50 years ago
9. Stanford researchers discover the anternet
10. By detecting smallest virus, researchers open possibilities for early disease detection
11. Behind closed doors: Researchers show how probiotics boost plant immunity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 16, 2014 Research and Markets ... addition of the "Global Chemical Sensor Market ... http://photos.prnewswire.com/prnh/20130307/600769 One ... increasing demand for medical sensors in biomedical applications. ... for quick and correct diagnosis during surgical procedures. ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... addition of the "Global Facial Recognition Market ... http://photos.prnewswire.com/prnh/20130307/600769 Facial ... of individuals. Facial recognition system measures the overall ... jaw edges, mouth, and the distance between eyes. ...
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition ... report to their offering. ... the adoption of multimodal biometric systems. Multimodal biometric ... individual for verification and identification purposes. This helps ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... AKRON, Ohio, June 16, 2011 Leaders within the ... to apply "Value-driven Engineering" (VdE) to enhance the development ... efficiency and reduced complexity.  VdE will become a key ... economy," maintain global competitiveness, and assure access to device ...
... Robert Blelloch, MD, PhD, has received the 2011 Outstanding Young ... for his pioneering research on the role of molecular tools ... Blelloch will present his research today, June 15, 2011, at ... p.m. EDT). He will participate in a press briefing at ...
... new Baylor University study has found that sunlight decreases the ... the southern United States every year. While golden algae ... Texas rivers and lakes, including Lake Whitney and Lake Waco ... believe that several environmental factors influence toxin production, but new ...
Cached Biology News:U.S. Biomedical Leaders Present a New National Device Innovation Strategy Based on "Value-driven Engineering" 2U.S. Biomedical Leaders Present a New National Device Innovation Strategy Based on "Value-driven Engineering" 3U.S. Biomedical Leaders Present a New National Device Innovation Strategy Based on "Value-driven Engineering" 4UCSF stem cell, cancer scientist honored for pioneering studies 2UCSF stem cell, cancer scientist honored for pioneering studies 3
(Date:12/17/2014)... , Dec. 17, 2014  United Therapeutics Corporation ... executive promotions as well as changes to Martine ... Executive Promotions United Therapeutics announced the ... and Co-Chief Executive Officer and David Zaccardelli , ... In connection with these promotions, Dr. Rothblatt,s title will ...
(Date:12/17/2014)... 2014   Synageva BioPharma Corp. (NASDAQ: ... for rare disorders, announced today its presentation at the ... San Francisco, CA. ... will present on Monday, January 12, 2015, at 9:00 ... webcast live and may be accessed from the "Webcasts ...
(Date:12/15/2014)... 2014 Organovo Holdings, Inc. (NYSE MKT: ... delivering breakthrough 3D bioprinting technology,  today celebrated continued ... its exVive3D TM Human Liver Tissue.  The ... commercial release on November 18, has been recognized ... awards for innovation. Most recently, on ...
(Date:12/15/2014)... , Dec. 15, 2014  Ascendis Pharma ... TransCon technology to address significant unmet medical needs, ... ongoing Phase 2 pediatric study to evaluate once-weekly ... deficiency, or GHD.  This interim analysis consists of ... total enrollment in the study, completing all six ...
Breaking Biology Technology:United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 2Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4
... Inc. (Nasdaq:,NUVA), a medical device company focused on developing ... today,details relating to its fourth quarter and full year ... 19, 2008, after,the close of the market., NuVasive ... 2008 at,5:30 p.m. ET / 2:30 p.m. PT to ...
... of Directors of US,Oncology Holdings, Inc. and its wholly ... "Company") announced that, effective,February 1, 2008, Dale Ross will ... and will continue as the Executive Chairman of the,Company. ... Company,s,President and CEO. The CEO transition is a planned ...
... investors to state, TOPEKA, Kan., Jan. 25 ... a "Come Home to Kansas" initiative that,focuses on ... Kansas. Partners in this project include the Kansas,Department ... Organization and the KTEC PIPELINE., This initiative ...
Cached Biology Technology:NuVasive Announces Webcast and Conference Call of Fourth Quarter and Full Year 2007 Results 2NuVasive Announces Webcast and Conference Call of Fourth Quarter and Full Year 2007 Results 3US Oncology Announces Realignment of Executive Team 2US Oncology Announces Realignment of Executive Team 3'Come Home to Kansas' Announced by KTEC 2
Anti-Phospho-JKK/SEK1/MKK4 pAb Description: 100 g rabbit polyclonal antibody. Reacts with human/mouse/rat. Tested in WB. Research Focus: signal transduction Storage: -20C Shipping Tem...
...
... Concentrated x 10 This pH 9.9 ... prior to immunohistochemical staining procedures. It is ... mounted on glass slides. For particular antigens, ... especially effective. It should be noted that ...
... SeMet White to off-white solid. ... ≥98% by HPLC. Soluble in H 2 ... prior to use. RTECS EK7713840, CAS 3211-76-5, ... 13, 8515.Jornot, L., and Junod, A.F. ...
Biology Products: